Journal of forensic sciences, 2016; 61 (3) doi:10.1111/1556-4029.13035
Affiliation: Sichuan University, China; Sichuan University, China; Chengdu University of Traditional Chinese Medicine, China; Sichuan University, China; Sichuan University, China (show more (1))
Abstract: The authors describe a case of a well-designed homicidal poisoning in China. A male was treated with starvation, intravenous fluids and antibiotics while in the hospital for acute diarrhea. He suddenly suffered from shortness of breath and subsequently died. A forensic autopsy was carried out, and several specimens were collected for toxicological screening. Propofol was tentatively identified in the blood by GC-MS. Based on the presence of propofol in the blood, a suspect confessed that two other drugs, namely midazolam and vecuronium, were involved in this murder. Analytical drug quantification was then performed by GC-MS and LC-MS/MS. Blood analysis revealed the following: propofol at 0.5 μg/mL, midazolam at 0.098 μg/mL, and vecuronium at 0.10 μg/mL. These results suggest that the cause of death was respiratory depression due to the acute combined effect of several anesthetic drugs administered by the victim's companion.
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