Interleukin-28B polymorphisms and response of chronic hepatitis C patients from Indonesia to pegylated interferon/ribavirin treatment.

Journal of clinical microbiology, 2014; 52 (6) doi:10.1128/JCM.00768-14

Authors: Juniastuti, Wibowo Bogi P, Wibawa I D N, Utsumi Takako, Mustika Syifa et al.(11)

Affiliation: Airlangga University, East Java, Indonesia; Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia; Sanglah General Hospital, Denpasar, Bali, Indonesia; Kobe University Graduate School of Medicine, Kobe, Hyōgo, Japan; Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia (show more (11))

Abstract: This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.

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