Lung inflammation in COPD: why does it matter?

F1000 medicine reports, 2012; 4 doi:10.3410/M4-23

Authors: Oh Jin Young, Sin Don D

Affiliation: St. Paul's Hospital Vancouver, British Columbia, Canada; Dongguk University Ilsan Hospital Goyang, South Korea

Abstract: COPD is characterized by lung inflammation, which intensifies with disease progression. Recent studies suggest that COPD has multiple phenotypes, each with a distinct molecular pathway. Proteolytic enzymes may have a prominent role in the emphysematous phenotype, while nitric oxide pathways may be more relevant for pulmonary vessel remodelling in COPD. This article provides a synopsis of the possible role that lung inflammation plays in the pathogenesis of COPD.

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