Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2012; 14 (7) doi:
Affiliation: Yuying Children's Hospital Affiliated to Wenzhou Medical College, China
Sample size: 3022
Abstract: OBJECTIVE: To investigate the positive rate of hepatitis B surface antibody (HBsAb) in children.
METHODS: Blood samples from 3022 children who received a physical examination in outpatient departments from 2009 to 2011 were subjected to serological test using ELISA to measure the positive rate of HBsAb.
RESULTS: The positive rate of HBsAb decreased with age (P<0.01). There was no significant difference in the positive rate of HBsAb between boys and girls (P>0.05), however the positive rate of HBsAb in boys aged one year and over was lower than in girls of the same age (P<0.01). The positive rate of HBsAb in boys aged between 3 and 4 years was higher than in girls of the same age (P<0.01). The positive rate of HBsAb decreased with age in boys, and was lower in those aged two years and over than in those aged one year and over (P<0.01). The positive rate of HBsAb also decreased with age in girls, with significant differences between different age groups (P<0.01).
CONCLUSIONS: The positive rate of HBsAb decreases with age in children, so younger children have a higher risk of infection with hepatitis B virus. Serological monitoring of hepatitis B needs to be enhanced.
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