Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia.

The American journal of tropical medicine and hygiene, 2010; 83 (1) doi:10.4269/ajtmh.2010.09-0589

Authors: Utsumi Takako, Yano Yoshihiko, Lusida Maria Inge, Amin Mochamad, Soetjipto et al.(2)

Affiliation: Airlangga University, Surabaya, East Java, Indonesia

Abstract: Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994-1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia.

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