Clinical chemistry, 2009; 55 (5) doi:10.1373/clinchem.2008.117929
Affiliation: Brigham and Women's Hospital, 02215, MA, United States
Sample size: 331
Abstract: BACKGROUND: National Cholesterol Education Program (NCEP) guidelines recommend development of direct assays for LDL cholesterol (LDL-C) measurement, but it is unclear how these assays compare with Friedewald calculation in predicting cardiovascular disease (CVD).
METHODS: In a study of 27 331 healthy women with triglycerides
CONCLUSIONS: The association of LDL-C with CVD by the 2 methods was nearly identical in fasting samples. However, the lower direct LDL-C concentrations may misclassify many individuals into a lower NCEP category. Moreover, the lack of association of nonfasting direct LDL-C with CVD raises questions regarding the clinical utility of a direct assay for LDL-C in nonfasting blood samples.
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