Clinical importance of HLA-DPB1 in haematopoietic cell transplantation.

Tissue antigens, 2007; 69 Suppl 1 doi:10.1111/j.1399-0039.2006.759_4.x

Authors: Shaw B E, Gooley T, Madrigal J A, Malkki M, Marsh S G E et al.(1)

Affiliation: Nottingham City Hospital, Nottingham, United Kingdom

Abstract: There is increasing evidence for a significant effect of human leukocyte antigen (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus.

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