Zhong Guangming

Top coauthors of Zhong Guangming

Lei Lei (26 papers)

Arulanandam Bernard P (23 papers)

Yang Zhangsheng (23 papers)

Murthy Ashlesh K (22 papers)

Zhong Youmin (22 papers)

List of Zhong Guangming publications


Pal Sukumar, Tifrea Delia F, Zhong Guangming, de la Maza Luis M 2018. "Transcervical Inoculation with Chlamydia trachomatis Induces Infertility in HLA-DR4 Transgenic and Wild-Type Mice." Infection and immunity 86 (1) doi:10.1128/IAI.00722-17
Shao Lili, Zhang Tianyuan, Melero Jose, Huang Yumeng, Liu Yuanjun, et al. 2018. "The Genital Tract Virulence Factor pGP3 Is Essential for Chlamydia muridarum Colonization in the Gastrointestinal Tract." Infection and immunity 86 (1) doi:10.1128/IAI.00429-17


Zhong Guangming 2017. "Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis." Trends in microbiology doi:10.1016/j.tim.2017.12.002
Wang Luying, Zhu Cuiming, Zhang Tianyuan, Tian Qi, Zhang Nu, et al. 2017. "Non-pathogenic colonization with Chlamydia in the gastrointestinal tract as oral vaccination for inducing transmucosal protection." Infection and immunity doi:10.1128/IAI.00630-17
Sun Xin, Tian Qi, Wang Luying, Xue Min, Zhong Guangming 2017. "IL-6-mediated signaling pathways limit Chlamydia muridarum infection and exacerbate its pathogenicity in the mouse genital tract." Microbes and infection 19 (11) doi:10.1016/j.micinf.2017.08.007
Brothwell Julie A, Muramatsu Matthew K, Zhong Guangming, Nelson David E 2017. "Advances and Obstacles in the Genetic Dissection of Chlamydial Virulence." Current topics in microbiology and immunology doi:10.1007/82_2017_76
Zhong Guangming, Brunham Robert C, de la Maza Luis M, Darville Toni, Deal Carolyn 2017. "National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward"." Vaccine doi:10.1016/j.vaccine.2017.10.075
Fan Huizhou, Zhong Guangming 2017. "2017: beginning of a new era for Chlamydia research in China and the rest of the world." Microbes and infection doi:10.1016/j.micinf.2017.09.009
Shao Lili, Zhang Tianyuan, Liu Quanzhong, Wang Jie, Zhong Guangming 2017. "Chlamydia muridarum with Mutations in Chromosomal Genes tc0237 and/or tc0668 Is Deficient in Colonizing the Mouse Gastrointestinal Tract." Infection and immunity 85 (8) doi:10.1128/IAI.00321-17
Wali Shradha, Gupta Rishein, Yu Jieh-Juen, Lanka Gopala Krishna Koundinya, Chambers James P, et al. 2017. "Chlamydial protease-like activity factor mediated protection against C. trachomatis in guinea pigs." Immunology and cell biology 95 (5) doi:10.1038/icb.2016.122
de la Maza Luis M, Zhong Guangming, Brunham Robert C 2017. "Update on Chlamydia trachomatis Vaccinology." Clinical and vaccine immunology : CVI 24 (4) doi:10.1128/CVI.00543-16
Zhang Yuyang, Shao Lili, Li Xiaodong, Zhong Guangming 2017. "Uterotubal junction prevents chlamydial ascension via innate immunity." PloS one 12 (8) doi:10.1371/journal.pone.0183189
Wang Yong, Liu Qiong, Chen Ding, Guan Jie, Ma Linghui, et al. 2017. "Chlamydial Lipoproteins Stimulate Toll-Like Receptors 1/2 Mediated Inflammatory Responses through MyD88-Dependent Pathway." Frontiers in microbiology 8 doi:10.3389/fmicb.2017.00078
Shao Lili, Melero Jose, Zhang Nu, Arulanandam Bernard, Baseman Joel, et al. 2017. "The cryptic plasmid is more important for Chlamydia muridarum to colonize the mouse gastrointestinal tract than to infect the genital tract." PloS one 12 (5) doi:10.1371/journal.pone.0177691


Lam Tonika, Kulp Dennis V, Wang Rui, Lou Zheng, Taylor Julia, et al. 2016. "Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus." Journal of immunology (Baltimore, Md. : 1950) doi:10.4049/jimmunol.1601427
Zhong Guangming 2016. "Chlamydial Plasmid-Dependent Pathogenicity." Trends in microbiology doi:10.1016/j.tim.2016.09.006
Yang Zhangsheng, Tang Lingli, Zhou Zhiguang, Zhong Guangming 2016. "Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF." Microbes and infection / Institut Pasteur doi:10.1016/j.micinf.2016.07.002
Yang Zhangsheng, Tang Lingli, Shao Lili, Zhang Yuyang, Zhang Tianyuan, et al. 2016. "The chlamydia-secreted protease CPAF promotes chlamydial survival in the mouse lower genital tract." Infection and immunity doi:10.1128/IAI.00280-16
Dai Jin, Zhang Tianyuan, Wang Luying, Shao Lili, Zhu Cuiming, et al. 2016. "Intravenous inoculation of Chlamydia muridarum leads to a long-lasting infection restricted to the gastrointestinal tract." Infection and immunity doi:10.1128/IAI.00432-16
Song Jianxin, Rao Yutao, Kim Jun Oh, Yin Bangshao, Zhou Mingbo, et al. 2016. "β-to-β 2,5-Pyrrolylene Linked Cyclic Porphyrin Oligomers." Chemistry (Weinheim an der Bergstrasse, Germany) doi:10.1002/chem.201601306
Lanka Gopala Krishna Koundinya, Yu Jieh-Juen, Gong Siqi, Gupta Rishein, Mustafa Shamimunisa B, et al. 2016. "IgA modulates respiratory dysfunction as a sequela to pulmonary chlamydial infection as neonates." Pathogens and disease 74 (3) doi:10.1093/femspd/ftv121
Wali Shradha, Gupta Rishein, Yu Jieh-Juen, Mfuh Adelphe, Gao Xiaoli, et al. 2016. "Guinea pig genital tract lipidome reveals in vivo and in vitro regulation of phosphatidylcholine 16:0/18:1 and contribution to Chlamydia trachomatis serovar D infectivity." Metabolomics : Official journal of the Metabolomic Society 12 (4) doi:10.1007/s11306-016-0998-5
Dutow Pavel, Wask Lea, Bothe Miriam, Fehlhaber Beate, Laudeley Robert, et al. 2016. "An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions." Pathogens and disease 74 (2) doi:10.1093/femspd/ftv120
Dai Jin, Tang Lingli, Chen Jianlin, Yu Ping, Chen Ze, Zhong Guangming 2016. "The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues." Microbes and infection / Institut Pasteur 18 (3) doi:10.1016/j.micinf.2015.11.003
Wang Luying, Zhang Qi, Zhang Tianyuan, Zhang Yuyang, Zhu Cuiming, et al. 2016. "The Chlamydia muridarum Organisms Fail to Auto-Inoculate the Mouse Genital Tract after Colonization in the Gastrointestinal Tract for 70 days." PloS one 11 (5) doi:10.1371/journal.pone.0155880


Hou Shuping, Dong Xiaohua, Yang Zhangsheng, Li Zhongyu, Liu Quanzhong, Zhong Guangming 2015. "Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37." Infection and immunity 83 (12) doi:10.1128/IAI.00746-15
Chen Chaoqun, Zhong Guangming, Ren Lin, Lu Chunxue, Li Zhonggyu, Wu Yimou 2015. "Identification of Plasmid-Free Chlamydia muridarum Organisms Using a Pgp3 Detection-Based Immunofluorescence Assay." Journal of microbiology and biotechnology 25 (10) doi:10.4014/jmb.1503.03072
Zhang Qi, Huang Yumeng, Gong Siqi, Yang Zhangsheng, Sun Xin, et al. 2015. "In Vivo and Ex Vivo Imaging Reveals a Long-Lasting Chlamydial Infection in the Mouse Gastrointestinal Tract following Genital Tract Inoculation." Infection and immunity 83 (9) doi:10.1128/IAI.00673-15
Sun Xin, Yang Zhangsheng, Zhang Hongbo, Dai Jin, Chen Jianlin, et al. 2015. "Chlamydia muridarum induction of glandular duct dilation in mice." Infection and immunity 83 (6) doi:10.1128/IAI.00154-15
Yang Zhangsheng, Tang Lingli, Sun Xin, Chai Jijie, Zhong Guangming 2015. "Characterization of CPAF critical residues and secretion during Chlamydia trachomatis infection." Infection and immunity 83 (6) doi:10.1128/IAI.00275-15
Chen Jianlin, Yang Zhangsheng, Sun Xin, Tang Lingli, Ding Yiling, et al. 2015. "Intrauterine infection with plasmid-free Chlamydia muridarum reveals a critical role of the plasmid in chlamydial ascension and establishes a model for evaluating plasmid-independent pathogenicity." Infection and immunity 83 (6) doi:10.1128/IAI.00353-15
Tang Lingli, Chen Jianlin, Zhou Zhiguang, Yu Ping, Yang Zhangsheng, Zhong Guangming 2015. "Chlamydia-secreted protease CPAF degrades host antimicrobial peptides." Microbes and infection / Institut Pasteur 17 (6) doi:10.1016/j.micinf.2015.02.005
Chen Chaoqun, Zhou Zhou, Conrad Turner, Yang Zhangsheng, Dai Jin, et al. 2015. "In vitro passage selects for Chlamydia muridarum with enhanced infectivity in cultured cells but attenuated pathogenicity in mouse upper genital tract." Infection and immunity 83 (5) doi:10.1128/IAI.03158-14
Conrad Turner Allen, Gong Siqi, Yang Zhangsheng, Matulich Patrick, Keck Jonathon, et al. 2015. "The Chromosome-Encoded Hypothetical Protein TC0668 Is an Upper Genital Tract Pathogenicity Factor of Chlamydia muridarum." Infection and immunity 84 (2) doi:10.1128/IAI.01171-15
Huang Yumeng, Zhang Qi, Yang Zhangsheng, Conrad Turner, Liu Yuanjun, Zhong Guangming 2015. "Plasmid-Encoded Pgp5 Is a Significant Contributor to Chlamydia muridarum Induction of Hydrosalpinx." PloS one 10 (4) doi:10.1371/journal.pone.0124840
Flores Rhonda, Zhong Guangming 2015. "The Chlamydia pneumoniae Inclusion Membrane Protein Cpn1027 Interacts with Host Cell Wnt Signaling Pathway Regulator Cytoplasmic Activation/Proliferation-Associated Protein 2 (Caprin2)." PloS one 10 (5) doi:10.1371/journal.pone.0127909


Liu Yuanjun, Huang Yumeng, Yang Zhangsheng, Sun Yina, Gong Siqi, et al. 2014. "Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice." Infection and immunity 82 (12) doi:10.1128/IAI.02576-14
Gupta Rishein, Wali Shradha, Yu Jieh-Juen, Chambers James P, Zhong Guangming, et al. 2014. "In vivo whole animal body imaging reveals colonization of Chlamydia muridarum to the lower genital tract at early stages of infection." Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 16 (5) doi:10.1007/s11307-014-0732-5
Yang Zhangsheng, Conrad Turner, Zhou Zhou, Chen Jianlin, Dutow Pavel, et al. 2014. "Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum." Infection and immunity 82 (8) doi:10.1128/IAI.01833-14
Zhong Guangming 2014. "Question the questions on CPAF." Pathogens and disease doi:10.1111/2049-632X.12205
Zhang Hongbo, Zhou Zhou, Chen Jianlin, Wu Ganqiu, Yang Zhangsheng, et al. 2014. "Lack of long-lasting hydrosalpinx in A/J mice correlates with rapid but transient chlamydial ascension and neutrophil recruitment in the oviduct following intravaginal inoculation with Chlamydia muridarum." Infection and immunity 82 (7) doi:10.1128/IAI.00055-14
Dong Xiaohua, Liu Yuanjun, Chang Xiaotong, Lei Lei, Zhong Guangming 2014. "Signaling via tumor necrosis factor receptor 1 but not Toll-like receptor 2 contributes significantly to hydrosalpinx development following Chlamydia muridarum infection." Infection and immunity 82 (5) doi:10.1128/IAI.01668-13
Tang Lingli, Yang Zhangsheng, Zhang Hongbo, Zhou Zhiguang, Arulanandam Bernard, et al. 2014. "Induction of protective immunity against Chlamydia muridarum intracervical infection in DBA/1j mice." Vaccine 32 (12) doi:10.1016/j.vaccine.2013.10.018
Lei Lei, Chen Jianlin, Hou Shuping, Ding Yiling, Yang Zhangsheng, et al. 2014. "Reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum." Infection and immunity 82 (3) doi:10.1128/IAI.01543-13
Liu Yuanjun, Chen Chaoqun, Gong Siqi, Hou Shuping, Qi Manli, et al. 2014. "Transformation of Chlamydia muridarum reveals a role for Pgp5 in suppression of plasmid-dependent gene expression." Journal of bacteriology 196 (5) doi:10.1128/JB.01161-13
Wali Shradha, Gupta Rishein, Veselenak Ronald L, Li Yansong, Yu Jieh-Juen, et al. 2014. "Use of a Guinea pig-specific transcriptome array for evaluation of protective immunity against genital chlamydial infection following intranasal vaccination in Guinea pigs." PloS one 9 (12) doi:10.1371/journal.pone.0114261
Campbell Jessica, Huang Yumeng, Liu Yuanjun, Schenken Robert, Arulanandam Bernard, Zhong Guangming 2014. "Bioluminescence imaging of Chlamydia muridarum ascending infection in mice." PloS one 9 (7) doi:10.1371/journal.pone.0101634
Chen Jianlin, Zhang Hongbo, Zhou Zhou, Yang Zhangsheng, Ding Yiling, et al. 2014. "Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology." PloS one 9 (4) doi:10.1371/journal.pone.0095076


A Conrad Turner, Yang Zhangsheng, Ojcius David, Zhong Guangming 2013. "A path forward for the chlamydial virulence factor CPAF." Microbes and infection / Institut Pasteur 15 (14-15) doi:10.1016/j.micinf.2013.09.008
Li Weidang, Murthy Ashlesh K, Lanka Gopala Krishna, Chetty Senthilnath L, Yu Jieh-Juen, et al. 2013. "A T cell epitope-based vaccine protects against chlamydial infection in HLA-DR4 transgenic mice." Vaccine 31 (48) doi:10.1016/j.vaccine.2013.09.036
Gong Siqi, Yang Zhangsheng, Lei Lei, Shen Li, Zhong Guangming 2013. "Characterization of Chlamydia trachomatis Plasmid-Encoded Open Reading Frames." Journal of bacteriology 195 (17) doi:10.1128/JB.00511-13
Chen Lili, Lei Lei, Zhou Zhou, He Jie, Xu Sha, et al. 2013. "Contribution of Interleukin-12 p35 (IL-12p35) and IL-12p40 to Protective Immunity and Pathology in Mice Infected with Chlamydia muridarum." Infection and immunity 81 (8) doi:10.1128/IAI.00161-13
Galaleldeen Ahmad, Taylor Alexander B, Chen Ding, Schuermann Jonathan P, Holloway Stephen P, et al. 2013. "Structure of the Chlamydia trachomatis Immunodominant Antigen Pgp3." The Journal of biological chemistry doi:10.1074/jbc.M113.475012
Zhou Hui, Huang Qiulin, Li Zhongyu, Wu Yimou, Xie Xiaobing, et al. 2013. "pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells." Science China. Life sciences 56 (5) doi:10.1007/s11427-013-4470-8
Igietseme Joseph U, Omosun Yusuf, Partin James, Goldstein Jason, He Qing, et al. 2013. "Prevention of Chlamydia-induced infertility by inhibition of local caspase activity." The Journal of infectious diseases 207 (7) doi:10.1093/infdis/jit009
Lu Chunxue, Peng Bo, Li Zhihong, Lei Lei, Li Zhongyu, et al. 2013. "Induction of protective immunity against Chlamydia muridarum intravaginal infection with the chlamydial immunodominant antigen macrophage infectivity potentiator." Microbes and infection / Institut Pasteur 15 (4) doi:10.1016/j.micinf.2013.02.001
Hou Shuping, Lei Lei, Yang Zhangsheng, Qi Manli, Liu Quanzhong, Zhong Guangming 2013. "Chlamydia trachomatis outer membrane complex protein B (OmcB) is processed by the protease CPAF." Journal of bacteriology 195 (5) doi:10.1128/JB.02087-12
Tang Lingli, Zhang Hongbo, Lei Lei, Gong Siqi, Zhou Zhiguang, et al. 2013. "Oviduct infection and hydrosalpinx in DBA1/j mice is induced by intracervical but not intravaginal inoculation with Chlamydia muridarum." PloS one 8 (8) doi:10.1371/journal.pone.0071649
Lu Chunxue, Lei Lei, Peng Bo, Tang Lingli, Ding Honglei, et al. 2013. "Chlamydia trachomatis GlgA is secreted into host cell cytoplasm." PloS one 8 (7) doi:10.1371/journal.pone.0068764
Lei Lei, Dong Xiaohua, Li Zhongyu, Zhong Guangming 2013. "Identification of a novel nuclear localization signal sequence in Chlamydia trachomatis-secreted hypothetical protein CT311." PloS one 8 (5) doi:10.1371/journal.pone.0064529
Ding Honglei, Gong Siqi, Tian Yingxin, Yang Zhangsheng, Brunham Robert, Zhong Guangming 2013. "Transformation of sexually transmitted infection-causing serovars of chlamydia trachomatis using Blasticidin for selection." PloS one 8 (11) doi:10.1371/journal.pone.0080534


Ouyang Zhenbo, Liu Ping, Yu Yanhong, Chen Chunlin, Song Xiaolei, et al. 2012. "Role of ovarian artery-to-uterine artery anastomoses in uterine artery embolization: initial anatomic and radiologic studies." Surgical and radiologic anatomy : SRA 34 (8) doi:10.1007/s00276-011-0883-x
Zeng Hao, Hou Shuping, Gong Siqi, Dong Xiaohua, Zou Quanming, Zhong Guangming 2012. "Mapping immunodominant antigens and H-2-linked antibody responses in mice urogenitally infected with Chlamydia muridarum." Microbes and infection / Institut Pasteur 14 (7-8) doi:10.1016/j.micinf.2012.02.005
Budrys Nicole M, Gong Siqi, Rodgers Allison K, Wang Jie, Louden Christopher, et al. 2012. "Chlamydia trachomatis antigens recognized in women with tubal factor infertility, normal fertility, and acute infection." Obstetrics and gynecology 119 (5) doi:10.1097/AOG.0b013e3182519326
Lu Chunxue, Holland Martin J, Gong Siqi, Peng Bo, Bailey Robin L, et al. 2012. "Genome-wide identification of Chlamydia trachomatis antigens associated with trachomatous trichiasis." Investigative ophthalmology & visual science 53 (6) doi:10.1167/iovs.11-9212
Zeng Hao, Gong Siqi, Hou Shuping, Zou Quanming, Zhong Guangming 2012. "Identification of antigen-specific antibody responses associated with upper genital tract pathology in mice infected with Chlamydia muridarum." Infection and immunity 80 (3) doi:10.1128/IAI.05894-11
Brown Tyler H T, David Jason, Acosta-Ramirez Elizabeth, Moore Jessica M, Lee Song, et al. 2012. "Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection." Vaccine 30 (2) doi:10.1016/j.vaccine.2011.10.086
Lu Chunxue, Zeng Hao, Li Zhihong, Lei Lei, Yeh I-Tien, et al. 2012. "Protective immunity against mouse upper genital tract pathology correlates with high IFNγ but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway." Vaccine 30 (2) doi:10.1016/j.vaccine.2011.10.059
Goodhew E Brook, Priest Jeffrey W, Moss Delynn M, Zhong Guangming, Munoz Beatriz, et al. 2012. "CT694 and pgp3 as serological tools for monitoring trachoma programs." PLoS neglected tropical diseases 6 (11) doi:10.1371/journal.pntd.0001873
Bose Rumu, Thinwa Josephine, Chaparro Paola, Zhong Youmin, Bose Santanu, et al. 2012. "Mitogen-activated protein kinase-dependent interleukin-1α intracrine signaling is modulated by YopP during Yersinia enterocolitica infection." Infection and immunity 80 (1) doi:10.1128/IAI.05742-11
Lei Lei, Li Zhongyu, Zhong Guangming 2012. "Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK)." PloS one 7 (9) doi:10.1371/journal.pone.0044733
Li Zhihong, Lu Chunxue, Peng Bo, Zeng Hao, Zhou Zhiguan, et al. 2012. "Induction of protective immunity against Chlamydia muridarum intravaginal infection with a chlamydial glycogen phosphorylase." PloS one 7 (3) doi:10.1371/journal.pone.0032997


Kari Laszlo, Whitmire William M, Olivares-Zavaleta Norma, Goheen Morgan M, Taylor Lacey D, et al. 2011. "A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates." The Journal of experimental medicine 208 (11) doi:10.1084/jem.20111266
Jupelli Madhulika, Murthy Ashlesh K, Chaganty Bharat K R, Guentzel M Neal, Selby Dale M, et al. 2011. "Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life." Laboratory investigation; a journal of technical methods and pathology 91 (10) doi:10.1038/labinvest.2011.103
Wang Jin, Frohlich Kyla M, Buckner Lyndsey, Quayle Alison J, Luo Miao, et al. 2011. "Altered protein secretion of Chlamydia trachomatis in persistently infected human endocervical epithelial cells." Microbiology (Reading, England) 157 (Pt 10) doi:10.1099/mic.0.044917-0
Rodgers Allison K, Budrys Nicole M, Gong Siqi, Wang Jie, Holden Alan, et al. 2011. "Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility." Fertility and sterility 96 (3) doi:10.1016/j.fertnstert.2011.06.021
Lei Lei, Qi Manli, Budrys Nicole, Schenken Robert, Zhong Guangming 2011. "Localization of Chlamydia trachomatis hypothetical protein CT311 in host cell cytoplasm." Microbial pathogenesis 51 (3) doi:10.1016/j.micpath.2011.05.002
Murthy Ashlesh K, Li Weidang, Chaganty Bharat K R, Kamalakaran Sangamithra, Guentzel M Neal, et al. 2011. "Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection." Infection and immunity 79 (7) doi:10.1128/IAI.05022-11
Qi Manli, Gong Siqi, Lei Lei, Liu Quanzhong, Zhong Guangming 2011. "A Chlamydia trachomatis OmcB C-terminal fragment is released into the host cell cytoplasm and is immunogenic in humans." Infection and immunity 79 (6) doi:10.1128/IAI.00003-11
Qi Manli, Lei Lei, Gong Siqi, Liu Quanzhong, DeLisa Matthew P, Zhong Guangming 2011. "Chlamydia trachomatis secretion of an immunodominant hypothetical protein (CT795) into host cell cytoplasm." Journal of bacteriology 193 (10) doi:10.1128/JB.01301-10
Gong Siqi, Lei Lei, Chang Xiaotong, Belland Robert, Zhong Guangming 2011. "Chlamydia trachomatis secretion of hypothetical protein CT622 into host cell cytoplasm via a secretion pathway that can be inhibited by the type III secretion system inhibitor compound 1." Microbiology (Reading, England) 157 (Pt 4) doi:10.1099/mic.0.047746-0
Murthy Ashlesh K, Li Weidang, Guentzel M Neal, Zhong Guangming, Arulanandam Bernard P 2011. "Vaccination with the defined chlamydial secreted protein CPAF induces robust protection against female infertility following repeated genital chlamydial challenge." Vaccine 29 (14) doi:10.1016/j.vaccine.2011.01.074
Meng Xiangzhi, Zhong Youmin, Embry Addie, Yan Bo, Lu Shan, et al. 2011. "Generation and characterization of a large panel of murine monoclonal antibodies against vaccinia virus." Virology 409 (2) doi:10.1016/j.virol.2010.10.019
Peng Bo, Lu Chunxue, Tang Lingli, Yeh I-Tien, He Zhimin, et al. 2011. "Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum." BMC infectious diseases 11 doi:10.1186/1471-2334-11-347
Wu Xiang, Lei Lei, Gong Siqi, Chen Ding, Flores Rhonda, Zhong Guangming 2011. "The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol." BMC microbiology 11 doi:10.1186/1471-2180-11-87
Li Weidang, Murthy Ashlesh K, Chaganty B K R, Guentzel M Neal, Seshu J, et al. 2011. "Immunization with dendritic cells pulsed ex vivo with recombinant chlamydial protease-like activity factor induces protective immunity against genital chlamydiamuridarum challenge." Frontiers in immunology 2 doi:10.3389/fimmu.2011.00073
Dehoux Pierre, Flores Rhonda, Dauga Catherine, Zhong Guangming, Subtil Agathe 2011. "Multi-genome identification and characterization of chlamydiae-specific type III secretion substrates: the Inc proteins." BMC genomics 12 doi:10.1186/1471-2164-12-109
Zhong Guangming 2011. "Chlamydia trachomatis secretion of proteases for manipulating host signaling pathways." Frontiers in microbiology 2 doi:10.3389/fmicb.2011.00014


Rodgers Allison K, Wang Jie, Zhang Yingqian, Holden Alan, Berryhill Blake, et al. 2010. "Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P." American journal of obstetrics and gynecology 203 (5) doi:10.1016/j.ajog.2010.06.005
Chen Ding, Lei Lei, Lu Chunxue, Galaleldeen Ahmad, Hart P John, Zhong Guangming 2010. "Characterization of Pgp3, a Chlamydia trachomatis plasmid-encoded immunodominant antigen." Journal of bacteriology 192 (22) doi:10.1128/JB.00847-10
Chen Ding, Lei Lei, Lu Chunxue, Flores Rhonda, DeLisa Matthew P, et al. 2010. "Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway." Microbiology (Reading, England) 156 (Pt 10) doi:10.1099/mic.0.040527-0
Chen Ding, Lei Lei, Flores Rhonda, Huang Zhiwei, Wu Zhongming, et al. 2010. "Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells." Microbial pathogenesis 49 (4) doi:10.1016/j.micpath.2010.05.008
Wang Jie, Zhang Yingqian, Yu Ping, Zhong Guangming 2010. "Immunodominant regions of a Chlamydia trachomatis type III secretion effector protein, Tarp." Clinical and vaccine immunology : CVI 17 (9) doi:10.1128/CVI.00218-10
Li Weidang, Murthy Ashlesh K, Guentzel M Neal, Chambers James P, Forsthuber Thomas G, et al. 2010. "Immunization with a combination of integral chlamydial antigens and a defined secreted protein induces robust immunity against genital chlamydial challenge." Infection and immunity 78 (9) doi:10.1128/IAI.00346-10
Wang Jie, Zhang Yingqian, Lu Chunxue, Lei Lei, Yu Ping, Zhong Guangming 2010. "A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans." Journal of immunology (Baltimore, Md. : 1950) 185 (3) doi:10.4049/jimmunol.1001240
Jupelli Madhulika, Selby Dale M, Guentzel M Neal, Chambers James P, Forsthuber Thomas G, et al. 2010. "The contribution of interleukin-12/interferon-gamma axis in protection against neonatal pulmonary Chlamydia muridarum challenge." Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 30 (6) doi:10.1089/jir.2009.0083
Liu Xiaoyun, Afrane Mary, Clemmer David E, Zhong Guangming, Nelson David E 2010. "Identification of Chlamydia trachomatis outer membrane complex proteins by differential proteomics." Journal of bacteriology 192 (11) doi:10.1128/JB.01628-09
Chen Fan, Cheng Wen, Zhang Saidan, Zhong Guangming, Yu Ping 2010. "[Induction of IL-8 by Chlamydia trachomatis through MAPK pathway rather than NF-kappaB pathway]." Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 35 (4) doi:10.3969/j.issn.1672-7347.2010.04.005
Chaganty Bharat K R, Murthy Ashlesh K, Evani Shankar J, Li Weidang, Guentzel M Neal, et al. 2010. "Heat denatured enzymatically inactive recombinant chlamydial protease-like activity factor induces robust protective immunity against genital chlamydial challenge." Vaccine 28 (11) doi:10.1016/j.vaccine.2009.12.064
Chen Lili, Lei Lei, Chang Xiaotong, Li Zhihong, Lu Chunxue, et al. 2010. "Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection." Journal of immunology (Baltimore, Md. : 1950) 184 (5) doi:10.4049/jimmunol.0901593
Chen Chunlin, Huang Rui, Liu Ping, Ouyang Zhenbo, Guo Hongxia, et al. 2010. "Construction and clinical significance of normal uterine arterial vascular network models." Gynecologic and obstetric investigation 69 (1) doi:10.1159/000245941


Murthy Ashlesh K, Guentzel M Neal, Zhong Guangming, Arulanandam Bernard P 2009. "Chlamydial protease-like activity factor--insights into immunity and vaccine development." Journal of reproductive immunology 83 (1-2) doi:10.1016/j.jri.2009.05.007
Zhong Guangming 2009. "Killing me softly: chlamydial use of proteolysis for evading host defenses." Trends in microbiology 17 (10) doi:10.1016/j.tim.2009.07.007
Rockey Daniel D, Wang Jie, Lei Lei, Zhong Guangming 2009. "Chlamydia vaccine candidates and tools for chlamydial antigen discovery." Expert review of vaccines 8 (10) doi:10.1586/erv.09.98
Rao Xiancai, Deighan Padraig, Hua Ziyu, Hu Xiaomei, Wang Jin, et al. 2009. "A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary sigma subunit." Genes & development 23 (15) doi:10.1101/gad.1784009
Zhang Xiaoyun, Gao Lifen, Lei Lei, Zhong Youmin, Dube Peter, et al. 2009. "A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum." Journal of immunology (Baltimore, Md. : 1950) 183 (2) doi:10.4049/jimmunol.0803075
Chen Lili, Cheng Wen, Shivshankar Pooja, Lei Lei, Zhang Xiaoyun, et al. 2009. "Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice." Infection and immunity 77 (7) doi:10.1128/IAI.00611-08
Wang Jie, Chen Lili, Chen Fan, Zhang Xiaoyun, Zhang Yingqian, et al. 2009. "A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity against upper genital tract pathologies in mice." Vaccine 27 (22) doi:10.1016/j.vaccine.2009.02.095
Chen Ding, Chai Jijie, Hart P John, Zhong Guangming 2009. "Identifying catalytic residues in CPAF, a Chlamydia-secreted protease." Archives of biochemistry and biophysics 485 (1) doi:
Murthy Ashlesh K, Chaganty Bharat K R, Li Weidang, Guentzel M Neal, Chambers James P, et al. 2009. "A limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge." FEMS immunology and medical microbiology 55 (2) doi:10.1111/j.1574-695X.2008.00517.x


Huang Zhiwei, Feng Yingcai, Chen Ding, Wu Xiaojing, Huang Siyang, et al. 2008. "Structural basis for activation and inhibition of the secreted chlamydia protease CPAF." Cell host & microbe 4 (6) doi:10.1016/j.chom.2008.10.005
Li Zhongyu, Wang Shiping, Wu Yimou, Zhong Guangming, Chen Ding 2008. "Immunization with chlamydial plasmid protein pORF5 DNA vaccine induces protective immunity against genital chlamydial infection in mice." Science in China. Series C, Life sciences / Chinese Academy of Sciences 51 (11) doi:10.1007/s11427-008-0130-9
Li Zhongyu, Chen Ding, Zhong Youmin, Wang Shiping, Zhong Guangming 2008. "The chlamydial plasmid-encoded protein pgp3 is secreted into the cytosol of Chlamydia-infected cells." Infection and immunity 76 (8) doi:10.1128/IAI.01377-07
Li Zhongyu, Chen Chaoqun, Chen Ding, Wu Yimou, Zhong Youmin, Zhong Guangming 2008. "Characterization of fifty putative inclusion membrane proteins encoded in the Chlamydia trachomatis genome." Infection and immunity 76 (6) doi:10.1128/IAI.00010-08
Jupelli Madhulika, Guentzel M Neal, Meier Patricia A, Zhong Guangming, Murthy Ashlesh K, Arulanandam Bernard P 2008. "Endogenous IFN-gamma production is induced and required for protective immunity against pulmonary chlamydial infection in neonatal mice." Journal of immunology (Baltimore, Md. : 1950) 180 (6) doi:
Li Weidang, Murthy Ashlesh K, Guentzel M Neal, Seshu J, Forsthuber Thomas G, et al. 2008. "Antigen-specific CD4+ T cells produce sufficient IFN-gamma to mediate robust protective immunity against genital Chlamydia muridarum infection." Journal of immunology (Baltimore, Md. : 1950) 180 (5) doi:
Cheng Wen, Shivshankar Pooja, Zhong Youmin, Chen Ding, Li Zhongyu, Zhong Guangming 2008. "Intracellular interleukin-1alpha mediates interleukin-8 production induced by Chlamydia trachomatis infection via a mechanism independent of type I interleukin-1 receptor." Infection and immunity 76 (3) doi:10.1128/IAI.01313-07
Shivshankar Pooja, Lei Lei, Wang Jie, Zhong Guangming 2008. "Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells." Applied and environmental microbiology 74 (4) doi:10.1128/AEM.02151-07
Cheng Wen, Shivshankar Pooja, Li Zhongyu, Chen Lili, Yeh I-Tien, Zhong Guangming 2008. "Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection." Infection and immunity 76 (2) doi:10.1128/IAI.01064-07
Li Zhongyu, Zhong Youmin, Lei Lei, Wu Yimou, Wang Shiping, Zhong Guangming 2008. "Antibodies from women urogenitally infected with C. trachomatis predominantly recognized the plasmid protein pgp3 in a conformation-dependent manner." BMC microbiology 8 doi:10.1186/1471-2180-8-90


Li Weidang, Guentzel M Neal, Seshu J, Zhong Guangming, Murthy Ashlesh K, Arulanandam Bernard P 2007. "Induction of cross-serovar protection against genital chlamydial infection by a targeted multisubunit vaccination approach." Clinical and vaccine immunology : CVI 14 (12) doi:10.1128/CVI.00274-07
Wang Guqi, Burczynski Frank, Anderson Judy, Zhong Guangming 2007. "Effect of host fatty acid-binding protein and fatty acid uptake on growth of Chlamydia trachomatis L2." Microbiology (Reading, England) 153 (Pt 6) doi:10.1099/mic.0.2006/003491-0
Cong Yu, Jupelli Madhulika, Guentzel M Neal, Zhong Guangming, Murthy Ashlesh K, Arulanandam Bernard P 2007. "Intranasal immunization with chlamydial protease-like activity factor and CpG deoxynucleotides enhances protective immunity against genital Chlamydia muridarum infection." Vaccine 25 (19) doi:10.1016/j.vaccine.2007.02.010
Flores Rhonda, Luo Jianhua, Chen Ding, Sturgeon Gracie, Shivshankar Pooja, et al. 2007. "Characterization of the hypothetical protein Cpn1027, a newly identified inclusion membrane protein unique to Chlamydia pneumoniae." Microbiology (Reading, England) 153 (Pt 3) doi:10.1099/mic.0.2006/002956-0
Murthy Ashlesh K, Chambers James P, Meier Patricia A, Zhong Guangming, Arulanandam Bernard P 2007. "Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production." Infection and immunity 75 (2) doi:10.1128/IAI.01280-06
Luo Jianhua, Jia Tianjun, Zhong Youmin, Chen Ding, Flores Rhonda, Zhong Guangming 2007. "Localization of the hypothetical protein Cpn0585 in the inclusion membrane of Chlamydia pneumoniae-infected cells." Microbial pathogenesis 42 (2-3) doi:10.1016/j.micpath.2006.11.006
Luo Jianhua, Jia Tianjun, Flores Rhonda, Chen Ding, Zhong Guangming 2007. "Hypothetical protein Cpn0308 is localized in the Chlamydia pneumoniae inclusion membrane." Infection and immunity 75 (1) doi:10.1128/IAI.00935-06
Luo Jianhua, Liu Guangchao, Zhong Youmin, Jia Tianjun, Liu Kaiyang, et al. 2007. "Characterization of hypothetical proteins Cpn0146, 0147, 0284 & 0285 that are predicted to be in the Chlamydia pneumoniae inclusion membrane." BMC microbiology 7 doi:10.1186/1471-2180-7-38


Zhong Youmin, Weininger Marilyn, Pirbhai Mustak, Dong Feng, Zhong Guangming 2006. "Inhibition of staurosporine-induced activation of the proapoptotic multidomain Bcl-2 proteins Bax and Bak by three invasive chlamydial species." The Journal of infection 53 (6) doi:10.1016/j.jinf.2005.12.028
Murthy Ashlesh K, Cong Yu, Murphey Cathi, Guentzel M Neal, Forsthuber Thomas G, et al. 2006. "Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele." Infection and immunity 74 (12) doi:10.1128/IAI.01119-06
Dong Feng, Flores Rhonda, Chen Ding, Luo Jianhua, Zhong Youmin, et al. 2006. "Localization of the hypothetical protein Cpn0797 in the cytoplasm of Chlamydia pneumoniae-infected host cells." Infection and immunity 74 (11) doi:10.1128/IAI.00855-06
Pirbhai Mustak, Dong Feng, Zhong Youmin, Pan Kelvin Z, Zhong Guangming 2006. "The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells." The Journal of biological chemistry 281 (42) doi:10.1074/jbc.M602796200
Chen Chaoqun, Chen Ding, Sharma Jyotika, Cheng Wen, Zhong Youmin, et al. 2006. "The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis." Infection and immunity 74 (8) doi:10.1128/IAI.00081-06
Murphey Cathi, Murthy Ashlesh K, Meier Patricia A, Neal Guentzel M, Zhong Guangming, Arulanandam Bernard P 2006. "The protective efficacy of chlamydial protease-like activity factor vaccination is dependent upon CD4+ T cells." Cellular immunology 242 (2) doi:10.1016/j.cellimm.2006.10.002
Balakrishnan Amit, Patel Bhairavi, Sieber Stephan A, Chen Ding, Pachikara Niseema, et al. 2006. "Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium." The Journal of biological chemistry 281 (24) doi:10.1074/jbc.M513648200
Sharma Jyotika, Zhong Youmin, Dong Feng, Piper Jeanna M, Wang Guqi, Zhong Guangming 2006. "Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins." Infection and immunity 74 (3) doi:10.1128/IAI.74.3.1490-1499.2006


Sharma Jyotika, Dong Feng, Pirbhai Mustak, Zhong Guangming 2005. "Inhibition of proteolytic activity of a chlamydial proteasome/protease-like activity factor by antibodies from humans infected with Chlamydia trachomatis." Infection and immunity 73 (7) doi:10.1128/IAI.73.7.4414-4419.2005
Chen Ling-Yu, Doerner Astrid, Lehmann Paul F, Huang Shuang, Zhong Guangming, Pan Zhixing K 2005. "A novel protein kinase C (PKCepsilon) is required for fMet-Leu-Phe-induced activation of NF-kappaB in human peripheral blood monocytes." The Journal of biological chemistry 280 (23) doi:10.1074/jbc.M413033200
Dong Feng, Pirbhai Mustak, Xiao Yangming, Zhong Youmin, Wu Yimou, Zhong Guangming 2005. "Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells." Infection and immunity 73 (3) doi:10.1128/IAI.73.3.1861-1864.2005
Dong Feng, Zhong Youmin, Arulanandam Bernard, Zhong Guangming 2005. "Production of a proteolytically active protein, chlamydial protease/proteasome-like activity factor, by five different Chlamydia species." Infection and immunity 73 (3) doi:10.1128/IAI.73.3.1868-1872.2005
Xiao Yangming, Zhong Youmin, Su Heng, Zhou Zhiguang, Chiao Paul, Zhong Guangming 2005. "NF-kappa B activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis." Journal of immunology (Baltimore, Md. : 1950) 174 (3) doi:


Sharma Jyotika, Bosnic Anthony M, Piper Jeanna M, Zhong Guangming 2004. "Human antibody responses to a Chlamydia-secreted protease factor." Infection and immunity 72 (12) doi:10.1128/IAI.72.12.7164-7171.2004
Xiao Yangming, Zhong Youmin, Greene Whitney, Dong Feng, Zhong Guangming 2004. "Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine." Infection and immunity 72 (9) doi:10.1128/IAI.72.9.5470-5474.2004
Murthy Ashlesh K, Sharma Jyotika, Coalson Jacqueline J, Zhong Guangming, Arulanandam Bernard P 2004. "Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice." Cellular immunology 230 (1) doi:10.1016/j.cellimm.2004.09.002
Dong Feng, Su Heng, Huang Yanqing, Zhong Youmin, Zhong Guangming 2004. "Cleavage of host keratin 8 by a Chlamydia-secreted protease." Infection and immunity 72 (7) doi:10.1128/IAI.72.7.3863-3868.2004
Dong Feng, Sharma Jyotika, Xiao Yanming, Zhong Youmin, Zhong Guangming 2004. "Intramolecular dimerization is required for the chlamydia-secreted protease CPAF to degrade host transcriptional factors." Infection and immunity 72 (7) doi:10.1128/IAI.72.7.3869-3875.2004
Dong Feng, Pirbhai Mustak, Zhong Youmin, Zhong Guangming 2004. "Cleavage-dependent activation of a chlamydia-secreted protease." Molecular microbiology 52 (5) doi:10.1111/j.1365-2958.2004.04072.x
Sharma Jyotika, Niu Yuhong, Ge Jianbo, Pierce Grant N, Zhong Guangming 2004. "Heat-inactivated C. pneumoniae organisms are not atherogenic." Molecular and cellular biochemistry 260 (1-2) doi:
Zettler Marjorie E, Prociuk Michele A, Austria J Alejandro, Zhong Guangming, Pierce Grant N 2004. "Oxidized low-density lipoprotein retards the growth of proliferating cells by inhibiting nuclear translocation of cell cycle proteins." Arteriosclerosis, thrombosis, and vascular biology 24 (4) doi:10.1161/01.ATV.0000120373.95552.aa
Su Heng, McClarty Grant, Dong Feng, Hatch Grant M, Pan Zhixing K, Zhong Guangming 2004. "Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids." The Journal of biological chemistry 279 (10) doi:10.1074/jbc.M312008200
Greene Whitney, Xiao Yangming, Huang Yanqing, McClarty Grant, Zhong Guangming 2004. "Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis." Infection and immunity 72 (1) doi:


Belland Robert J, Zhong Guangming, Crane Deborah D, Hogan Daniel, Sturdevant Daniel, et al. 2003. "Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis." Proceedings of the National Academy of Sciences of the United States of America 100 (14) doi:10.1073/pnas.1331135100
Greene Whitney, Zhong Guangming 2003. "Inhibition of host cell cytokinesis by Chlamydia trachomatis infection." The Journal of infection 47 (1) doi:
Zettler Marjorie E, Prociuk Michele A, Austria J Alejandro, Massaeli Hamid, Zhong Guangming, Pierce Grant N 2003. "OxLDL stimulates cell proliferation through a general induction of cell cycle proteins." American journal of physiology. Heart and circulatory physiology 284 (2) doi:10.1152/ajpheart.00494.2001


Wang Guqi, Burczynski Frank, Hasinoff Brian, Zhong Guangming 2002. "Infection of myocytes with chlamydiae." Microbiology (Reading, England) 148 (Pt 12) doi:
Fan Peiyi, Dong Feng, Huang Yanqing, Zhong Guangming 2002. "Chlamydia pneumoniae secretion of a protease-like activity factor for degrading host cell transcription factors required for [correction of factors is required for] major histocompatibility complex antigen expression." Infection and immunity 70 (1) doi: