Timens Wim

Top coauthors of Timens Wim

Postma Dirkje S (93 papers)

Bossé Yohan (25 papers)

Hylkema Machteld N (24 papers)

Brandsma Corry-Anke (23 papers)

van den Berge Maarten (21 papers)

List of Timens Wim publications

2018

Wei Jiacong, van der Wekken Anthonie J, Saber Ali, Terpstra Miente M, Schuuring Ed, et al. 2018. "Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers." Cancers 10 (1) doi:10.3390/cancers10010010

2017

Brandsma Corry-Anke, de Vries Maaike, Costa Rita, Woldhuis Roy R, Königshoff Melanie, Timens Wim 2017. "Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?" European respiratory review : an official journal of the European Respiratory Society 26 (146) doi:10.1183/16000617.0073-2017
Boudewijn Ilse M, Faiz Alen, Steiling Katrina, van der Wiel Erica, Telenga Eef D, et al. 2017. "Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression." Respiratory research 18 (1) doi:10.1186/s12931-017-0696-5
de Vries Maaike, Faiz Alen, Woldhuis Roy R, Postma Dirkje S, de Jong Tristan V, et al. 2017. "Lung tissue gene-expression signature for the ageing lung in COPD." Thorax doi:10.1136/thoraxjnl-2017-210074
Meyer Karolin F, Verkaik-Schakel Rikst Nynke, Timens Wim, Kobzik Lester, Plösch Torsten, Hylkema Machteld N 2017. "The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific." Epigenetics doi:10.1080/15592294.2017.1403691
Allen Richard J, Porte Joanne, Braybrooke Rebecca, Flores Carlos, Fingerlin Tasha E, et al. 2017. "Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study." The Lancet. Respiratory medicine 5 (11) doi:10.1016/S2213-2600(17)30387-9
Obeidat Ma'en, Li Xuan, Burgess Stephen, Zhou Guohai, Fishbane Nick, et al. 2017. "Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation." The European respiratory journal 50 (5) doi:10.1183/13993003.00657-2017
Conickx Griet, Avila Cobos Francisco, van den Berge Maarten, Faiz Alen, Timens Wim, et al. 2017. "microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach." Scientific reports 7 (1) doi:10.1038/s41598-017-13265-8
Boorsma Carian E, van der Veen T Anienke, Putri Kurnia S S, de Almeida Andreia, Draijer Christina, et al. 2017. "A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages." Scientific reports 7 (1) doi:10.1038/s41598-017-12623-w
Obeidat Ma'en, Nie Yunlong, Fishbane Nick, Li Xuan, Bossé Yohan, et al. 2017. "Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers." American journal of respiratory cell and molecular biology 57 (4) doi:10.1165/rcmb.2016-0284OC
McKay James D, Hung Rayjean J, Han Younghun, Zong Xuchen, Carreras-Torres Robert, et al. 2017. "Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes." Nature genetics 49 (7) doi:10.1038/ng.3892
Klinkenberg Theo J, Dinjens Lars, Wolf Rienhart F E, van der Wekken Anthonie J, van de Wauwer Caroline, et al. 2017. "CT-guided percutaneous hookwire localization increases the efficacy and safety of VATS for pulmonary nodules." Journal of surgical oncology 115 (7) doi:10.1002/jso.24589
Osei Emmanuel T, Florez-Sampedro Laura, Tasena Hataitip, Faiz Alen, Noordhoek Jacobien A, et al. 2017. "miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD." The European respiratory journal 49 (5) doi:10.1183/13993003.02538-2016
Tania Navessa P, Maarsingh Harm, T Bos I Sophie, Mattiotti Andrea, Prakash Stuti, et al. 2017. "Endothelial follistatin-like-1 regulates the postnatal development of the pulmonary vasculature by modulating BMP/Smad signaling." Pulmonary circulation 7 (1) doi:10.1177/2045893217702340
Hobbs Brian D, de Jong Kim, Lamontagne Maxime, Bossé Yohan, Shrine Nick, et al. 2017. "Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis." Nature genetics 49 (3) doi:10.1038/ng.3752
Saber Ali, Hiltermann T Jeroen N, Kok Klaas, Terpstra M Martijn, de Lange Kim, et al. 2017. "Mutation patterns in small cell and non-small cell lung cancer patients suggest a different level of heterogeneity between primary and metastatic tumors." Carcinogenesis 38 (2) doi:10.1093/carcin/bgw128
Ong Jennie, Timens Wim, Rajendran Vijay, Algra Arjan, Spira Avrum, et al. 2017. "Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts." PloS one 12 (9) doi:10.1371/journal.pone.0183815
Kunz Lisette I Z, Ten Hacken Nick H T, Lapperre Thérèse S, Timens Wim, Kerstjens Huib A M, et al. 2017. "Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids." The European respiratory journal 49 (1) doi:10.1183/13993003.00839-2016

2016

Nieuwenhuis Maartje A, Siedlinski Matteusz, van den Berge Maarten, Granell Raquel, Li Xingnan, et al. 2016. "Combining Genome Wide Association Study and lung eQTL analysis provides evidence for novel genes associated with asthma." Allergy doi:10.1111/all.12990
Osei Emmanuel T, Noordhoek Jacobien A, Hackett Tillie L, Spanjer Anita I R, Postma Dirkje S, et al. 2016. "Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD." The European respiratory journal doi:10.1183/13993003.01911-2015
Pore Milind, Meijer Coby, de Bock Geertruida H, Boersma-van Ek Wytske, Terstappen Leon W M M, et al. 2016. "Cancer Stem Cells, Epithelial to Mesenchymal Markers, and Circulating Tumor Cells in Small Cell Lung Cancer." Clinical lung cancer doi:10.1016/j.cllc.2016.05.015
Scheel Andreas H, Ansén Sascha, Schultheis Anne M, Scheffler Matthias, Fischer Rieke N, et al. 2016. "PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations." Oncoimmunology 5 (5) doi:10.1080/2162402X.2015.1131379
Fehringer Gordon, Kraft Peter, Pharoah Paul D P, Eeles Rosalind A, Chatterjee Nilanjan, et al. 2016. "Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations." Cancer research doi:10.1158/0008-5472.CAN-15-2980
Spanjer Anita I R, Menzen Mark H, Dijkstra Akkelies E, van den Berge Maarten, Boezen H Marike, et al. 2016. "A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis." Thorax 71 (4) doi:10.1136/thoraxjnl-2015-206958
Schieck Maximilian, Schouten Jan P, Michel Sven, Suttner Kathrin, Toncheva Antoaneta A, et al. 2016. "Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages." The Journal of allergy and clinical immunology doi:10.1016/j.jaci.2015.12.1305
Leuenberger Caroline, Schuoler Claudio, Bye Hannah, Mignan Célia, Rechsteiner Thomas, et al. 2016. "MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD." Journal of molecular medicine (Berlin, Germany) doi:10.1007/s00109-016-1388-1
Draijer Christina, Hylkema Machteld N, Boorsma Carian E, Klok Pieter A, Robbe Patricia, et al. 2016. "Sexual maturation protects against development of lung inflammation through estrogen." American journal of physiology. Lung cellular and molecular physiology 310 (2) doi:10.1152/ajplung.00119.2015
Szulcek Robert, Happé Chris M, Rol Nina, Fontijn Ruud D, Dickhoff Chris, et al. 2016. "Delayed Microvascular Shear-adaptation in Pulmonary Arterial Hypertension: Role of PECAM-1 Cleavage." American journal of respiratory and critical care medicine doi:10.1164/rccm.201506-1231OC
Saber Ali, van der Wekken Anthonie J, Kerner Gerald S M A, van den Berge Maarten, Timens Wim, et al. 2016. "Chronic Obstructive Pulmonary Disease Is Not Associated with KRAS Mutations in Non-Small Cell Lung Cancer." PloS one 11 (3) doi:10.1371/journal.pone.0152317
Faura Tellez Grissel, Willemse Brigitte W M, Brouwer Uilke, Nijboer-Brinksma Susan, Vandepoele Karl, et al. 2016. "Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma." PloS one 11 (10) doi:10.1371/journal.pone.0163967
Saber Ali, van der Wekken Anthonie J, Kok Klaas, Terpstra M Martijn, Bosman Lisette J, et al. 2016. "Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing." PloS one 11 (4) doi:10.1371/journal.pone.0153065
Fattahi Fatemeh, Brandsma Corry-Anke, Lodewijk Monique, Reinders-Luinge Marjan, Postma Dirkje S, et al. 2016. "Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17+ Cells in Asthmatic Airways." PloS one 11 (8) doi:10.1371/journal.pone.0161433
Hoonhorst Susan J M, Lo Tam Loi Adèle T, Pouwels Simon D, Faiz Alen, Telenga Eef D, et al. 2016. "Advanced glycation endproducts and their receptor in different body compartments in COPD." Respiratory research 17 doi:10.1186/s12931-016-0363-2

2015

de Jong Kim, Vonk Judith M, Timens Wim, Bossé Yohan, Sin Don D, et al. 2015. "Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels." The Journal of allergy and clinical immunology 136 (6) doi:10.1016/j.jaci.2015.03.042
Ngkelo Anta, Hoffmann Roland F, Durham Andrew L, Marwick John A, Brandenburg Simone M, et al. 2015. "Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD." American journal of physiology. Lung cellular and molecular physiology 309 (10) doi:10.1152/ajplung.00077.2015
Fattahi Fatemeh, Vonk Judith M, Bulkmans Nicole, Fleischeuer Ruth, Gouw Annette, et al. 2015. "Old dilemma: asthma with irreversible airway obstruction or COPD." Virchows Archiv : an international journal of pathology 467 (5) doi:10.1007/s00428-015-1824-6
Saferali Aabida, Obeidat Ma'en, Bérubé Jean-Christophe, Lamontagne Maxime, Bossé Yohan, et al. 2015. "Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis." American journal of respiratory cell and molecular biology 53 (5) doi:10.1165/rcmb.2014-0182OC
Obeidat Ma'en, Hao Ke, Bossé Yohan, Nickle David C, Nie Yunlong, et al. 2015. "Molecular mechanisms underlying variations in lung function: a systems genetics analysis." The Lancet. Respiratory medicine 3 (10) doi:10.1016/S2213-2600(15)00380-X
Osei Emmanuel T, Florez-Sampedro Laura, Timens Wim, Postma Dirkje S, Heijink Irene H, Brandsma Corry-Anke 2015. "Unravelling the complexity of COPD by microRNAs: it's a small world after all." The European respiratory journal 46 (3) doi:10.1183/13993003.02139-2014
Poppinga Wilfred J, Heijink Irene H, Holtzer Laura J, Skroblin Philipp, Klussmann Enno, et al. 2015. "A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle." American journal of physiology. Lung cellular and molecular physiology 308 (8) doi:10.1152/ajplung.00301.2014
Ridderbos Floris-Jan S, Wolff Djoeke, Timmer Albertus, van Melle Joost P, Ebels Tjark, et al. 2015. "Adverse pulmonary vascular remodeling in the Fontan circulation." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 34 (3) doi:10.1016/j.healun.2015.01.005
Poirier Julia G, Brennan Paul, McKay James D, Spitz Margaret R, Bickeböller Heike, et al. 2015. "Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer." Genetic epidemiology 39 (3) doi:10.1002/gepi.21882
Robbe Patricia, Draijer Christina, Borg Thiago R, Luinge Marjan, Timens Wim, et al. 2015. "Distinct macrophage phenotypes in allergic and nonallergic lung inflammation." American journal of physiology. Lung cellular and molecular physiology 308 (4) doi:10.1152/ajplung.00341.2014
van Mastrigt Esther, Vanlaeken Leonie, Heida Fardou, Caudri Daan, de Jongste Johan C, et al. 2015. "The clinical utility of reticular basement membrane thickness measurements in asthmatic children." The Journal of asthma : official journal of the Association for the Care of Asthma 52 (9) doi:10.3109/02770903.2015.1025409
Snoeck-Stroband Jiska B, Lapperre Therese S, Sterk Peter J, Hiemstra Pieter S, Thiadens Henk A, et al. 2015. "Prediction of Long-Term Benefits of Inhaled Steroids by Phenotypic Markers in Moderate-to-Severe COPD: A Randomized Controlled Trial." PloS one 10 (12) doi:10.1371/journal.pone.0143793
Lane Jérôme, van Eeden Stephan F, Obeidat Ma'en, Sin Don D, Tebbutt Scott J, et al. 2015. "Impact of Statins on Gene Expression in Human Lung Tissues." PloS one 10 (11) doi:10.1371/journal.pone.0142037
Dijkstra Akkelies E, Smolonska Joanna, van den Berge Maarten, Wijmenga Ciska, Zanen Pieter, et al. 2015. "Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study." PloS one 10 (5) doi:10.1371/journal.pone.0129524
Brandsma Corry-Anke, van den Berge Maarten, Postma Dirkje S, Jonker Marnix R, Brouwer Sharon, et al. 2015. "A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD." Thorax 70 (1) doi:10.1136/thoraxjnl-2014-205091
Jansen Sepp R, Holman Rian, Hedemann Ilja, Frankes Ewoud, Elzinga Carolina R S, et al. 2015. "Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization." Journal of cellular and molecular medicine 19 (1) doi:10.1111/jcmm.12418

2014

Nguyen Justin Dang Uy, Lamontagne Maxime, Couture Christian, Conti Massimo, Paré Peter D, et al. 2014. "Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung." Carcinogenesis 35 (12) doi:10.1093/carcin/bgu184
Oldenburger Anouk, Timens Wim, Bos Sophie, Smit Marieke, Smrcka Alan V, et al. 2014. "Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 (11) doi:10.1096/fj.13-248930
Cree Ian A, Deans Zandra, Ligtenberg Marjolijn J L, Normanno Nicola, Edsjö Anders, et al. 2014. "Guidance for laboratories performing molecular pathology for cancer patients." Journal of clinical pathology 67 (11) doi:10.1136/jclinpath-2014-202404
Lamontagne Maxime, Timens Wim, Hao Ke, Bossé Yohan, Laviolette Michel, et al. 2014. "Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction." Thorax 69 (11) doi:10.1136/thoraxjnl-2014-205630
Chen Ling, Ge Qi, Tjin Gavin, Alkhouri Hatem, Deng Linghong, et al. 2014. "Effects of cigarette smoke extract on human airway smooth muscle cells in COPD." The European respiratory journal 44 (3) doi:10.1183/09031936.00171313
Oldenburger Anouk, Poppinga Wilfred J, Kos Fleur, de Bruin Harold G, Rijks Wolter F, et al. 2014. "A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke." American journal of physiology. Cell physiology 306 (6) doi:10.1152/ajpcell.00183.2013
van den Berge Maarten, Steiling Katrina, Timens Wim, Hiemstra Pieter S, Sterk Peter J, et al. 2014. "Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity." Thorax 69 (1) doi:10.1136/thoraxjnl-2012-202878
Hoonhorst Susan J M, ten Hacken Nick H T, Vonk Judith M, Timens Wim, Hiemstra Pieter S, et al. 2014. "Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers." PloS one 9 (2) doi:10.1371/journal.pone.0087443
Dijkstra Akkelies E, Smolonska Joanna, van den Berge Maarten, Wijmenga Ciska, Zanen Pieter, et al. 2014. "Susceptibility to chronic mucus hypersecretion, a genome wide association study." PloS one 9 (4) doi:10.1371/journal.pone.0091621
Morissette Mathieu C, Lamontagne Maxime, Bérubé Jean-Christophe, Gaschler Gordon, Williams Andrew, et al. 2014. "Impact of cigarette smoke on the human and mouse lungs: a gene-expression comparison study." PloS one 9 (3) doi:10.1371/journal.pone.0092498
Franciosi Lorenza, Postma Dirkje S, van den Berge Maarten, Govorukhina Natalia, Horvatovich Peter L, et al. 2014. "Susceptibility to COPD: differential proteomic profiling after acute smoking." PloS one 9 (7) doi:10.1371/journal.pone.0102037
Bouma Wobbe, Klinkenberg Theo J, Van De Wauwer Caroline, Timens Wim, Mariani Massimo A 2014. "Removal of a giant intrathoracic cyst from the anterior mediastinum." Journal of cardiothoracic surgery 9 doi:10.1186/s13019-014-0152-2
Hoonhorst Susan J M, Timens Wim, Koenderman Leo, Lo Tam Loi Adèle T, Lammers Jan-Willem J, et al. 2014. "Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD." Respiratory research 15 doi:10.1186/s12931-014-0121-2

2013

Brandsma Corry-Anke, Timens Wim, Jonker Marnix R, Rutgers Bea, Noordhoek Jacobien A, Postma Dirkje S 2013. "Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD." American journal of physiology. Lung cellular and molecular physiology 305 (8) doi:10.1152/ajplung.00152.2013
Ricciardolo Fabio L M, Sabatini Federica, Sorbello Valentina, Benedetto Sabrina, Defilippi Ilaria, et al. 2013. "Expression of vascular remodelling markers in relation to bradykinin receptors in asthma and COPD." Thorax doi:10.1136/thoraxjnl-2012-202741
Baarsma Hoeke A, Engelbertink Lilian Hjm, van Hees Lonneke J, Menzen Mark H, Meurs Herman, et al. 2013. "Glycogen synthase kinase-3 (GSK-3) regulates TGF-β1 -induced differentiation of pulmonary fibroblasts." British journal of pharmacology 169 (3) doi:10.1111/bph.12098
Franciosi Lorenza, Govorukhina Natalia, Fusetti Fabrizia, Poolman Bert, Lodewijk Monique E, et al. 2013. "Proteomic analysis of human Epithelial Lining Fluid by microfluidics-based nanoLC-MS/MS: a feasibility study." Electrophoresis doi:10.1002/elps.201300020
Steiling Katrina, van den Berge Maarten, Hijazi Kahkeshan, Florido Roberta, Campbell Joshua, et al. 2013. "A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment." American journal of respiratory and critical care medicine 187 (9) doi:10.1164/rccm.201208-1449OC
van Krieken J Han, Normanno Nicola, Blackhall Fiona, Boone Elke, Botti Gerardo, et al. 2013. "Guideline on the requirements of external quality assessment programs in molecular pathology." Virchows Archiv : an international journal of pathology 462 (1) doi:10.1007/s00428-012-1354-4
Fattahi Fatemeh, ten Hacken Nick H T, Löfdahl Claes-Göran, Hylkema Machteld N, Timens Wim, et al. 2013. "Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study." Respiratory research 14 doi:10.1186/1465-9921-14-10
Volbeda Franke, Broekema Martine, Lodewijk Monique E, Hylkema Machteld N, Reddel Helen K, et al. 2013. "Clinical control of asthma associates with measures of airway inflammation." Thorax 68 (1) doi:10.1136/thoraxjnl-2012-201861
Overbeek Saskia A, Braber Saskia, Koelink Pim J, Henricks Paul A J, Mortaz Esmaeil, et al. 2013. "Correction: Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?" PloS one 8 (10) doi:10.1371/annotation/0faf4c12-4fd4-474c-b5a4-16e49370aff3
Kunz Lisette I Z, Strebus Jolanda, Budulac Simona E, Lapperre Therese S, Sterk Peter J, et al. 2013. "Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: A Randomized, Controlled Trial." PloS one 8 (5) doi:10.1371/journal.pone.0063430
Kerner Gerald S M A, Schuuring Ed, Sietsma Johanna, Hiltermann Thijo J N, Pieterman Remge M, et al. 2013. "Common and rare EGFR and KRAS mutations in a Dutch non-small-cell lung cancer population and their clinical outcome." PloS one 8 (7) doi:10.1371/journal.pone.0070346
Lamontagne Maxime, Couture Christian, Postma Dirkje S, Timens Wim, Sin Don D, et al. 2013. "Refining susceptibility loci of chronic obstructive pulmonary disease with lung eqtls." PloS one 8 (7) doi:10.1371/journal.pone.0070220
Lo Tam Loi Adèle T, Hoonhorst Susan J M, Franciosi Lorenza, Bischoff Rainer, Hoffmann Roland F, et al. 2013. "Acute and chronic inflammatory responses induced by smoking in individuals susceptible and non-susceptible to development of COPD: from specific disease phenotyping towards novel therapy. Protocol of a cross-sectional study." BMJ open 3 (2) doi:10.1136/bmjopen-2012-002178
Christenson Stephanie A, Brandsma Corry-Anke, Campbell Joshua D, Knight Darryl A, Pechkovsky Dmitri V, et al. 2013. "miR-638 regulates gene expression networks associated with emphysematous lung destruction." Genome medicine 5 (12) doi:10.1186/gm519
Thun Gian Andri, Imboden Medea, Ferrarotti Ilaria, Kumar Ashish, Obeidat Ma'en, et al. 2013. "Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels." PLoS genetics 9 (8) doi:10.1371/journal.pgen.1003585
Overbeek Saskia A, Braber Saskia, Koelink Pim J, Henricks Paul A J, Mortaz Esmaeil, et al. 2013. "Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?" PloS one 8 (1) doi:10.1371/journal.pone.0055612

2012

Budulac Simona E, Postma Dirkje S, Hiemstra Pieter S, Lapperre Thérèse S, Kunz Lisette I Z, et al. 2012. "Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD." European journal of pharmacology 696 (1-3) doi:10.1016/j.ejphar.2012.08.015
Lambeck Annechien J A, Verschuuren Erik A, Bouwman Ilby, Jongsma Theo, Roozendaal Caroline, et al. 2012. "Successful lung transplantation in the presence of pre-existing donor-specific cytotoxic HLA Class II antibodies." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 31 (12) doi:10.1016/j.healun.2012.09.015
van den Berge Maarten, Vonk Judith M, Gosman Margot, Lapperre Thérèse S, Snoeck-Stroband Jiska B, et al. 2012. "Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD." The European respiratory journal 40 (5) doi:10.1183/09031936.00169711
Peifer Martin, Fernández-Cuesta Lynnette, Sos Martin L, George Julie, Seidel Danila, et al. 2012. "Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer." Nature genetics 44 (10) doi:10.1038/ng.2396
Campbell Joshua D, McDonough John E, Zeskind Julie E, Hackett Tillie L, Pechkovsky Dmitri V, et al. 2012. "A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK." Genome medicine 4 (8) doi:10.1186/gm368
Brandsma Corry-Anke, Kerstjens Huib A M, van Geffen Wouter H, Geerlings Marie, Postma Dirkje S, et al. 2012. "Differential switching to IgG and IgA in active smoking COPD patients and healthy controls." The European respiratory journal 40 (2) doi:10.1183/09031936.00011211
Bossé Yohan, Postma Dirkje S, Sin Don D, Lamontagne Maxime, Couture Christian, et al. 2012. "Molecular signature of smoking in human lung tissues." Cancer research 72 (15) doi:10.1158/0008-5472.CAN-12-1160
Oldenburger Anouk, Roscioni Sara S, Jansen Esther, Menzen Mark H, Halayko Andrew J, et al. 2012. "Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease." PloS one 7 (2) doi:10.1371/journal.pone.0031574
Hao Ke, Bossé Yohan, Nickle David C, Paré Peter D, Postma Dirkje S, et al. 2012. "Lung eQTLs to help reveal the molecular underpinnings of asthma." PLoS genetics 8 (11) doi:10.1371/journal.pgen.1003029
Budulac Simona E, Boezen H Marike, Hiemstra Pieter S, Lapperre Therese S, Vonk Judith M, et al. 2012. "Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease." PloS one 7 (8) doi:10.1371/journal.pone.0043124
Budulac Simona E, Vonk Judith M, Postma Dirkje S, Siedlinski Mateusz, Timens Wim, Boezen Marike H 2012. "Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD." PloS one 7 (3) doi:10.1371/journal.pone.0033386

2011

Liesker Jeroen J W, Bathoorn Erik, Postma Dirkje S, Vonk Judith M, Timens Wim, Kerstjens Huib A M 2011. "Sputum inflammation predicts exacerbations after cessation of inhaled corticosteroids in COPD." Respiratory medicine 105 (12) doi:10.1016/j.rmed.2011.07.002
Hammerman Peter S, Sos Martin L, Ramos Alex H, Xu Chunxiao, Dutt Amit, et al. 2011. "Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer." Cancer discovery 1 (1) doi:10.1158/2159-8274.CD-11-0005
Piet Berber, de Bree Godelieve J, Smids-Dierdorp Barbara S, van der Loos Chris M, Remmerswaal Ester B M, et al. 2011. "CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung." The Journal of clinical investigation 121 (6) doi:10.1172/JCI44675
Boelens Mirjam C, Gustafson Adam M, Postma Dirkje S, Kok Klaas, van der Vries Gerben, et al. 2011. "A chronic obstructive pulmonary disease related signature in squamous cell lung cancer." Lung cancer (Amsterdam, Netherlands) 72 (2) doi:10.1016/j.lungcan.2010.08.014
Fattahi Fatemeh, Hylkema Machteld N, Melgert Barbro N, Timens Wim, Postma Dirkje S, ten Hacken Nick H T 2011. "Smoking and nonsmoking asthma: differences in clinical outcome and pathogenesis." Expert review of respiratory medicine 5 (1) doi:10.1586/ers.10.85
Broekema Martine, Timens Wim, Vonk Judith M, Volbeda Franke, Lodewijk Monique E, et al. 2011. "Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma." American journal of respiratory and critical care medicine 183 (3) doi:10.1164/rccm.201003-0494OC
Kunz Lisette I Z, Lapperre Thérèse S, Snoeck-Stroband Jiska B, Budulac Simona E, Timens Wim, et al. 2011. "Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD." Respiratory research 12 doi:10.1186/1465-9921-12-34
Baarsma Hoeke A, Spanjer Anita I R, Haitsma Gertruud, Engelbertink Lilian H J M, Meurs Herman, et al. 2011. "Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease." PloS one 6 (9) doi:10.1371/journal.pone.0025450
Groen Harry J M, Hiltermann Thijo J N, Schuuring Ed, Timens Wim 2011. "[New 'targeted therapy' for lung cancer]." Nederlands tijdschrift voor geneeskunde 155 (45) doi:

2010

Weiss Jonathan, Sos Martin L, Seidel Danila, Peifer Martin, Zander Thomas, et al. 2010. "Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer." Science translational medicine 2 (62) doi:10.1126/scitranslmed.3001451
den Bakker Michael A, Willemsen Sten, Grünberg Katrien, Noorduijn L Arnold, van Oosterhout Matthijs F M, et al. 2010. "Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability." Histopathology 56 (3) doi:10.1111/j.1365-2559.2010.03486.x
Budulac Simona E, Postma Dirkje S, Hiemstra Pieter S, Kunz Lisette I Z, Siedlinski Mateusz, et al. 2010. "Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD." Respiratory research 11 doi:10.1186/1465-9921-11-60
Volbeda Franke, ten Hacken Nick H T, Lodewijk Monique E, Dijkstra Antoon, Hylkema Machteld N, et al. 2010. "Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?" Respiratory research 11 doi:10.1186/1465-9921-11-106
Brandsma Corry-Anke, Timens Wim, Geerlings Marie, Jekel Henrike, Postma Dirkje S, et al. 2010. "Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice." BMC pulmonary medicine 10 doi:10.1186/1471-2466-10-64

2009

Broekema Martine, ten Hacken Nick H T, Volbeda Franke, Lodewijk Monique E, Hylkema Machteld N, et al. 2009. "Airway epithelial changes in smokers but not in ex-smokers with asthma." American journal of respiratory and critical care medicine 180 (12) doi:10.1164/rccm.200906-0828OC
van Klaveren Rob J, Oudkerk Matthijs, Prokop Mathias, Scholten Ernst T, Nackaerts Kristiaan, et al. 2009. "Management of lung nodules detected by volume CT scanning." The New England journal of medicine 361 (23) doi:10.1056/NEJMoa0906085
Boelens Mirjam C, Kok Klaas, van der Vlies Pieter, van der Vries Gerben, Sietsma Hannie, et al. 2009. "Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis." Lung cancer (Amsterdam, Netherlands) 66 (3) doi:10.1016/j.lungcan.2009.02.017
Koppelman Gerard H, Meyers Deborah A, Howard Timothy D, Zheng S Lilly, Hawkins Greg A, et al. 2009. "Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness." American journal of respiratory and critical care medicine 180 (10) doi:10.1164/rccm.200810-1621OC
Lapperre Thérèse S, Snoeck-Stroband Jiska B, Gosman Margot M E, Jansen Désirée F, van Schadewijk Annemarie, et al. 2009. "Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial." Annals of internal medicine 151 (8) doi:
Boelens Mirjam C, van den Berg Anke, Fehrmann Rudolf S N, Geerlings Marie, de Jong Wouter K, et al. 2009. "Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer." The Journal of pathology 218 (2) doi:10.1002/path.2520
Dijkstra Antoon, Postma Dirkje S, Noordhoek Jacobien A, Lodewijk Monique E, Kauffman Henk F, et al. 2009. "Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung." Virchows Archiv : an international journal of pathology 454 (4) doi:10.1007/s00428-009-0748-4
Versluis Mieke, ten Hacken Nick, Postma Dirkje, Barroso Begona, Rutgers Bea, et al. 2009. "Adenosine receptors in COPD and asymptomatic smokers: effects of smoking cessation." Virchows Archiv : an international journal of pathology 454 (3) doi:10.1007/s00428-009-0727-9
Hogg James C, Timens Wim 2009. "The pathology of chronic obstructive pulmonary disease." Annual review of pathology 4 doi:10.1146/annurev.pathol.4.110807.092145
Liesker Jeroen J W, Ten Hacken Nick H, Zeinstra-Smith Mieke, Rutgers Steven R, Postma Dirkje S, Timens Wim 2009. "Reticular basement membrane in asthma and COPD: similar thickness, yet different composition." International journal of chronic obstructive pulmonary disease 4 doi:
Brandsma Corry-Anke, Hylkema Machteld N, Geerlings Marie, van Geffen Wouter H, Postma Dirkje S, et al. 2009. "Increased levels of (class switched) memory B cells in peripheral blood of current smokers." Respiratory research 10 doi:10.1186/1465-9921-10-108

2008

Versluis Mieke, Postma Dirkje S, Timens Wim, Hylkema Machteld N 2008. "Effects of IL-4 and IL-13 on adenosine receptor expression and responsiveness of the human mast cell line 1." International immunopharmacology 8 (6) doi:10.1016/j.intimp.2008.02.001
Gosman Margot M E, Postma Dirkje S, Vonk Judith M, Rutgers Bea, Lodewijk Monique, et al. 2008. "Association of mast cells with lung function in chronic obstructive pulmonary disease." Respiratory research 9 doi:10.1186/1465-9921-9-64
Bathoorn Erik, Kerstjens Huib, Postma Dirkje, Timens Wim, MacNee William 2008. "Airways inflammation and treatment during acute exacerbations of COPD." International journal of chronic obstructive pulmonary disease 3 (2) doi:
de Jong Wouter K, Blaauwgeers Johannes L G, Schaapveld Michael, Timens Wim, Klinkenberg Theo J, Groen Harry J M 2008. "Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy." European journal of cancer (Oxford, England : 1990) 44 (1) doi:10.1016/j.ejca.2007.11.004
Brandsma Corry-Anke, Hylkema Machteld N, van der Strate Barry W A, Slebos Dirk-Jan, Luinge Marjan A, et al. 2008. "Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?" Respiratory research 9 doi:10.1186/1465-9921-9-17
Brandsma Corry-Anke, Hylkema Machteld N, Luinge Marjan A, Geerlings Marie, Klok Pieter A, et al. 2008. "Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice." Inhalation toxicology 20 (2) doi:10.1080/08958370701821342
Zandvoort Andre, Postma Dirkje S, Jonker Marnix R, Noordhoek Jacobien A, Vos Johannes T W M, Timens Wim 2008. "Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD." Respiratory research 9 doi:10.1186/1465-9921-9-83
van der Deen Margaretha, Homan Sandra, Timmer-Bosscha Hetty, Scheper Rik J, Timens Wim, et al. 2008. "Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells." International journal of chronic obstructive pulmonary disease 3 (3) doi:

2007

Melgert Barbro N, Ray Anuradha, Hylkema Machteld N, Timens Wim, Postma Dirkje S 2007. "Are there reasons why adult asthma is more common in females?" Current allergy and asthma reports 7 (2) doi:
Bresser Paul, Cornelissen Marion I, van der Bij Wim, van Noesel Carel J M, Timens Wim 2007. "Idiopathic pulmonary arterial hypertension in Dutch Caucasian patients is not associated with human herpes virus-8 infection." Respiratory medicine 101 (4) doi:10.1016/j.rmed.2006.08.015
van der Deen Margaretha, de Vries Elisabeth G E, Visserman Hylke, Zandbergen Wouter, Postma Dirkje S, et al. 2007. "Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells." Journal of biochemical and molecular toxicology 21 (5) doi:10.1002/jbt.20187
Lapperre Thérèse S, Sont Jacob K, van Schadewijk Annemarie, Gosman Margot Me, Postma Dirkje S, et al. 2007. "Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study." Respiratory research 8 doi:10.1186/1465-9921-8-85
van der Deen Margaretha, Timens Wim, Timmer-Bosscha Hetty, van der Strate Barry W, Scheper Rik J, et al. 2007. "Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice." Respiratory research 8 doi:10.1186/1465-9921-8-49
Boelens Mirjam C, te Meerman Gerard J, Gibcus Johan H, Blokzijl Tjasso, Boezen H Marike, et al. 2007. "Microarray amplification bias: loss of 30% differentially expressed genes due to long probe - poly(A)-tail distances." BMC genomics 8 doi:10.1186/1471-2164-8-277
Lapperre Thérèse S, Willems Luuk N A, Timens Wim, Rabe Klaus F, Hiemstra Pieter S, et al. 2007. "Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD." Chest 131 (1) doi:10.1378/chest.06-0796

2006

van der Deen Margaretha, Marks Hendrik, Willemse Brigitte W M, Postma Dirkje S, Müller Michael, et al. 2006. "Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients." Virchows Archiv : an international journal of pathology 449 (6) doi:10.1007/s00428-006-0240-3
Shilo Konstantin, Miettinen Markku, Travis William D, Timens Wim, Nogueira Rosete, Franks Teri J 2006. "Pulmonary microcystic fibromyxoma: Report of 3 cases." The American journal of surgical pathology 30 (11) doi:10.1097/01.pas.0000213279.53338.32
van der Vaart Hester, Postma Dirkje S, Timens Wim, Kauffman Henk F, Hylkema Machteld N, Ten Hacken Nick H T 2006. "Repeated sputum inductions induce a transient neutrophilic and eosinophilic response." Chest 130 (4) doi:10.1378/chest.130.4.1157
Postma Dirkje S, Timens Wim 2006. "Remodeling in asthma and chronic obstructive pulmonary disease." Proceedings of the American Thoracic Society 3 (5) doi:10.1513/pats.200601-006AW
Fokkema Eelco, Timens Wim, de Vries Elisabeth G E, de Jong Steven, Fidler Vaclav, et al. 2006. "Expression and prognostic implications of apoptosis-related proteins in locally unresectable non-small cell lung cancers." Lung cancer (Amsterdam, Netherlands) 52 (2) doi:10.1016/j.lungcan.2005.12.009
van der Strate Barry W A, Postma Dirkje S, Brandsma Corry-Anke, Melgert Barbro N, Luinge Marjan A, et al. 2006. "Cigarette smoke-induced emphysema: A role for the B cell?" American journal of respiratory and critical care medicine 173 (7) doi:10.1164/rccm.200504-594OC

2005

Willemse Brigitte, Lesman-Leegte Ivonne, Timens Wim, Postma Dirkje, ten Hacken Nick 2005. "High cessation rates of cigarette smoking in subjects with and without COPD." Chest 128 (5) doi:10.1378/chest.128.5.3685
Qu Ning, de Vos Paul, Schelfhorst Maaike, de Haan Aalzen, Timens Wim, Prop Jochum 2005. "Integrity of airway epithelium is essential against obliterative airway disease in transplanted rat tracheas." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 24 (7) doi:10.1016/j.healun.2004.04.020
van den Berg Arjen, Kuiper Mathys, Snoek Mieke, Timens Wim, Postma Dirkje S, et al. 2005. "Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells." American journal of respiratory cell and molecular biology 33 (1) doi:10.1165/rcmb.2005-0022OC
Noordhoek Jacobien A, Postma Dirkje S, Chong Luis L, Menkema Lorian, Kauffman Henk F, et al. 2005. "Different modulation of decorin production by lung fibroblasts from patients with mild and severe emphysema." COPD 2 (1) doi:
van der Vaart Hester, Postma Dirkje S, Timens Wim, Hylkema Machteld N, Willemse Brigitte W M, et al. 2005. "Acute effects of cigarette smoking on inflammation in healthy intermittent smokers." Respiratory research 6 doi:10.1186/1465-9921-6-22
Willemse Brigitte W M, ten Hacken Nick H T, Rutgers Bea, Postma Dirkje S, Timens Wim 2005. "Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers." Respiratory research 6 doi:10.1186/1465-9921-6-38
van der Deen Margaretha, de Vries Elisabeth G E, Timens Wim, Scheper Rik J, Timmer-Bosscha Hetty, Postma Dirkje S 2005. "ATP-binding cassette (ABC) transporters in normal and pathological lung." Respiratory research 6 doi:10.1186/1465-9921-6-59

2004

van den Berg Jan W K, Slebos Dirk-Jan, Postma Dirkje S, Dijkhuizen Brigitte, Koëter Gerard H, et al. 2004. "Feasibility of sputum induction in lung transplant recipients." Clinical transplantation 18 (5) doi:10.1111/j.1399-0012.2004.00237.x
Slebos Dirk-Jan, Verschuuren Erik A M, Koëter Gerard H, van der Bij Wim, Kauffman Henk F, et al. 2004. "Bronchoalveolar lavage in a patient with recurrence of sarcoidosis after lung transplantation." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 23 (8) doi:10.1016/j.healun.2003.08.010
Melgert Barbro N, Postma Dirkje S, Geerlings Marie, Luinge Marjan A, Klok Pieter A, et al. 2004. "Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice." American journal of respiratory cell and molecular biology 30 (6) doi:10.1165/rcmb.2003-0178OC
Kramer Henk, Pieterman Remge M, Slebos Dirk-Jan, Timens Wim, Vaalburg Willem, et al. 2004. "PET for the evaluation of pleural thickening observed on CT." Journal of nuclear medicine : official publication, Society of Nuclear Medicine 45 (6) doi:
Oostendorp Jaap, Hylkema Machteld N, Luinge Marjan, Geerlings Marie, Meurs Herman, et al. 2004. "Localization and enhanced mRNA expression of the orphan chemokine receptor L-CCR in the lung in a murine model of ovalbumin-induced airway inflammation." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 52 (3) doi:
Niessen Frank B, Schalkwijk Joost, Vos Hans, Timens Wim 2004. "Hypertrophic scar formation is associated with an increased number of epidermal Langerhans cells." The Journal of pathology 202 (1) doi:10.1002/path.1502

2003

Leeuw Jan A, Koudstaal Jan, Wiersema-Buist Janneke, Kamps Willem A, Timens Wim 2003. "Bone histomorphometry in children with newly diagnosed acute lymphoblastic leukemia." Pediatric research 54 (6) doi:10.1203/01.PDR.0000090929.16450.DE
Spierings Diana C J, de Vries Elisabeth G E, Timens Wim, Groen Harry J M, Boezen H Marike, de Jong Steven 2003. "Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors." Clinical cancer research : an official journal of the American Association for Cancer Research 9 (9) doi:
Noordhoek Jacobien A, Postma Dirkje S, Chong Luis L, Vos Johannes T W M, Kauffman Henk F, et al. 2003. "Different proliferative capacity of lung fibroblasts obtained from control subjects and patients with emphysema." Experimental lung research 29 (5) doi:
Verschuuren Erik, van der Bij Wim, de Boer Wim, Timens Wim, Middeldorp Jaap, The T Hauw 2003. "Quantitative Epstein-Barr virus (EBV) serology in lung transplant recipients with primary EBV infection and/or post-transplant lymphoproliferative disease." Journal of medical virology 69 (2) doi:10.1002/jmv.10273
Ten Hacken Nick H T, Postma Dirkje S, Timens Wim 2003. "Airway remodeling and long-term decline in lung function in asthma." Current opinion in pulmonary medicine 9 (1) doi:

2002

Fokkema Eelco, Groen Harry J M, Meijer Coby, Timens Wim, de Jong Steven, de Vries Elisabeth G E 2002. "The role of apoptosis-related genes in non-small-cell lung cancer." Clinical lung cancer 4 (3) doi:
Hylkema Machteld N, Timens Wim, Luinge Marjan, Van Der Werf Nienke, Hoekstra Maarten O 2002. "The effect of bacillus Calmette-Guérin immunization depends on the genetic predisposition to Th2-type responsiveness." American journal of respiratory cell and molecular biology 27 (2) doi:10.1165/ajrcmb.27.2.4735