Saavedra Juan M

Top coauthors of Saavedra Juan M

Benicky Julius (19 papers)

Pavel Jaroslav (15 papers)

Armando Ines (14 papers)

Pang Tao (11 papers)

Zhou Jin (9 papers)

List of Saavedra Juan M publications

2018

Wang Yunjie, Huang Yun, Xu Yazhou, Ruan Wenchen, Wang Haojie, et al. 2018. "A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization." Antioxidants & redox signaling 28 (2) doi:10.1089/ars.2017.7003
Wang Yunjie, Ruan Wenchen, Mi Junru, Xu Jingzi, Wang Haojie, et al. 2018. "Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions." Brain, behavior, and immunity 67 doi:10.1016/j.bbi.2017.08.006

2017

Kabba John Alimamy, Xu Yazhou, Christian Handson, Ruan Wenchen, Chenai Kitchen, et al. 2017. "Microglia: Housekeeper of the Central Nervous System." Cellular and molecular neurobiology doi:10.1007/s10571-017-0504-2
Zhou June, Burns Mark P, Huynh Linda, Villapol Sonia, Taub Daniel D, et al. 2017. "Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice." Frontiers in endocrinology 8 doi:10.3389/fendo.2017.00231
Canedo-Marroquín Gisela, Acevedo-Acevedo Orlando, Rey-Jurado Emma, Saavedra Juan M, Lay Margarita K, et al. 2017. "Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity." Frontiers in cellular and infection microbiology 7 doi:10.3389/fcimb.2017.00367

2016

Saavedra Juan M 2016. "Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer's Disease." Cellular and molecular neurobiology doi:10.1007/s10571-015-0327-y
Elkahloun Abdel G, Hafko Roman, Saavedra Juan M 2016. "An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease." Alzheimer's research & therapy 8 (1) doi:10.1186/s13195-015-0167-5

2015

Gao Yuanxue, Xu Xiaojun, Chang Sai, Wang Yunjie, Xu Yazhou, et al. 2015. "Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction." Toxicology and applied pharmacology 289 (2) doi:10.1016/j.taap.2015.10.001
Xu Yuan, Xu Yazhou, Wang Yurong, Wang Yunjie, He Ling, et al. 2015. "Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation." Brain, behavior, and immunity 50 doi:10.1016/j.bbi.2015.07.015
Villapol Sonia, Balarezo María G, Affram Kwame, Saavedra Juan M, Symes Aviva J 2015. "Neurorestoration after traumatic brain injury through angiotensin II receptor blockage." Brain : a journal of neurology 138 (Pt 11) doi:10.1093/brain/awv172
Villapol Sonia, Kryndushkin Dmitry, Balarezo Maria G, Campbell Ashley M, Saavedra Juan M, et al. 2015. "Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan." The American journal of pathology 185 (10) doi:10.1016/j.ajpath.2015.06.016
Villapol Sonia, Saavedra Juan M 2015. "Neuroprotective effects of angiotensin receptor blockers." American journal of hypertension 28 (3) doi:10.1093/ajh/hpu197

2014

Wang Juan, Pang Tao, Hafko Roman, Benicky Julius, Sanchez-Lemus Enrique, Saavedra Juan M 2014. "Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT(1) receptor blockade and PPARγ activation." Neuropharmacology 79 doi:10.1016/j.neuropharm.2013.11.022
Hafko Roman, Villapol Sonia, Nostramo Regina, Symes Aviva, Sabban Esther L, et al. 2014. "Correction: Commercially Available Angiotensin II AT2 Receptor Antibodies Are Nonspecific." PloS one 9 (1) doi:10.1371/annotation/beee9a88-80e1-4332-ac02-c1845beaa71b

2013

Sohn Young In, Lee Nathanael J, Chung Andrew, Saavedra Juan M, Scott Turner R, et al. 2013. "Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking." Biochemical and biophysical research communications 439 (4) doi:10.1016/j.bbrc.2013.08.091
Hafko Roman, Villapol Sonia, Nostramo Regina, Symes Aviva, Sabban Esther L, et al. 2013. "Commercially available angiotensin II At₂ receptor antibodies are nonspecific." PloS one 8 (7) doi:10.1371/journal.pone.0069234

2012

Villapol Sonia, Yaszemski Alexandra K, Logan Trevor T, Sánchez-Lemus Enrique, Saavedra Juan M, Symes Aviva J 2012. "Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 37 (13) doi:10.1038/npp.2012.152
Benicky Julius, Hafko Roman, Sanchez-Lemus Enrique, Aguilera Greti, Saavedra Juan M 2012. "Six commercially available angiotensin II AT(1) receptor antibodies are non-specific." Cellular and molecular neurobiology 32 (8) doi:10.1007/s10571-012-9862-y
Saavedra Juan M 2012. "Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders." Clinical science (London, England : 1979) 123 (10) doi:10.1042/CS20120078
Nostramo Regina, Tillinger Andrej, Saavedra Juan M, Kumar Ashok, Pandey Varunkumar, et al. 2012. "Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress." The Journal of endocrinology 215 (2) doi:10.1530/JOE-12-0181
Saavedra Juan M 2012. "Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders." Cellular and molecular neurobiology 32 (5) doi:10.1007/s10571-011-9754-6
Sánchez-Lemus Enrique, Honda Masaru, Saavedra Juan M 2012. "Angiotensin II AT1 receptor blocker candesartan prevents the fast up-regulation of cerebrocortical benzodiazepine-1 receptors induced by acute inflammatory and restraint stress." Behavioural brain research 232 (1) doi:10.1016/j.bbr.2012.03.041
Pang Tao, Wang Juan, Benicky Julius, Saavedra Juan M 2012. "Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition." Biochimica et biophysica acta 1820 (4) doi:10.1016/j.bbagen.2012.01.011
Pang Tao, Benicky Julius, Wang Juan, Orecna Martina, Sanchez-Lemus Enrique, Saavedra Juan M 2012. "Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes." Journal of hypertension 30 (1) doi:10.1097/HJH.0b013e32834dde5f
Pang Tao, Wang Juan, Benicky Julius, Sánchez-Lemus Enrique, Saavedra Juan M 2012. "Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways." Journal of neuroinflammation 9 doi:10.1186/1742-2094-9-102

2011

Benicky Julius, Sánchez-Lemus Enrique, Honda Masaru, Pang Tao, Orecna Martina, et al. 2011. "Angiotensin II AT1 receptor blockade ameliorates brain inflammation." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 36 (4) doi:10.1038/npp.2010.225
Saavedra Juan M, Sánchez-Lemus Enrique, Benicky Julius 2011. "Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications." Psychoneuroendocrinology 36 (1) doi:10.1016/j.psyneuen.2010.10.001

2010

Patil Jaspal, Schwab Alexander, Nussberger Juerg, Schaffner Thomas, Saavedra Juan M, Imboden Hans 2010. "Intraneuronal angiotensinergic system in rat and human dorsal root ganglia." Regulatory peptides 162 (1-3) doi:10.1016/j.regpep.2010.03.004

2009

Larrayoz Ignacio M, Pang Tao, Benicky Julius, Pavel Jaroslav, Sánchez-Lemus Enrique, Saavedra Juan M 2009. "Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes." Journal of hypertension 27 (12) doi:10.1097/HJH.0b013e3283314bc7
Pavel Jaroslav, Terrón José A, Benicky Julius, Falcón-Neri Alicia, Rachakonda Amita, et al. 2009. "Increased angiotensin II AT1 receptor mRNA and binding in spleen and lung of AT2 receptor gene disrupted mice." Regulatory peptides 158 (1-3) doi:10.1016/j.regpep.2009.09.004
Sánchez-Lemus Enrique, Benicky Julius, Pavel Jaroslav, Saavedra Juan M 2009. "In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland." Brain, behavior, and immunity 23 (7) doi:10.1016/j.bbi.2009.04.012
Benicky Julius, Sánchez-Lemus Enrique, Pavel Jaroslav, Saavedra Juan M 2009. "Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery." Cellular and molecular neurobiology 29 (6-7) doi:10.1007/s10571-009-9368-4
Sánchez-Lemus Enrique, Benicky Julius, Pavel Jaroslav, Larrayoz Ignacio M, Zhou Jin, et al. 2009. "Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen." American journal of physiology. Regulatory, integrative and comparative physiology 296 (5) doi:10.1152/ajpregu.90962.2008
Imboden Hans, Patil Jaspal, Nussberger Juerg, Nicoud Françoise, Hess Benno, et al. 2009. "Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia." Regulatory peptides 154 (1-3) doi:10.1016/j.regpep.2009.02.002
Tang Hui, Pavel Jaroslav, Saavedra Juan M, Brimijoin Stephen 2009. "Type-1 angiotensin receptors are expressed and transported in motor and sensory axons of rat sciatic nerves." Neuropeptides 43 (2) doi:10.1016/j.npep.2009.01.001
Macova Miroslava, Pavel Jaroslav, Saavedra Juan M 2009. "A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH." Brain research 1250 doi:10.1016/j.brainres.2008.11.006

2008

Pavel Jaroslav, Tang Hui, Brimijoin Stephen, Moughamian Armen, Nishioku Tsuyoshi, et al. 2008. "Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the rat." Brain research 1246 doi:10.1016/j.brainres.2008.09.099
Pavel Jaroslav, Benicky Julius, Murakami Yuki, Sanchez-Lemus Enrique, Saavedra Juan M 2008. "Peripherally administered angiotensin II AT1 receptor antagonists are anti-stress compounds in vivo." Annals of the New York Academy of Sciences 1148 doi:10.1196/annals.1410.006
Sanchez-Lemus Enrique, Murakami Yuki, Larrayoz-Roldan Ignacio M, Moughamian Armen J, Pavel Jaroslav, et al. 2008. "Angiotensin II AT1 receptor blockade decreases lipopolysaccharide-induced inflammation in the rat adrenal gland." Endocrinology 149 (10) doi:10.1210/en.2008-0242
Tang Hui, Pavel Jaroslav, Saavedra Juan M, Brimijoin Stephen 2008. "Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage." Neurological research 30 (7) doi:10.1179/174313208X298020
Sommer Wolfgang H, Saavedra Juan M 2008. "Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders." Journal of molecular medicine (Berlin, Germany) 86 (6) doi:10.1007/s00109-008-0333-3
Macova Miroslava, Armando Ines, Zhou Jin, Baiardi Gustavo, Tyurmin Dmitri, et al. 2008. "Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats." Neuroendocrinology 88 (4) doi:10.1159/000150977

2007

Saavedra Juan M, Benicky Julius 2007. "Brain and peripheral angiotensin II play a major role in stress." Stress (Amsterdam, Netherlands) 10 (2) doi:10.1080/10253890701350735
Armando Ines, Volpi Simona, Aguilera Greti, Saavedra Juan M 2007. "Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress." Brain research 1142 doi:10.1016/j.brainres.2007.01.037

2006

Zorad Stefan, Dou Jing-tao, Benicky Julius, Hutanu Daniel, Tybitanclova Katarina, et al. 2006. "Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma." European journal of pharmacology 552 (1-3) doi:10.1016/j.ejphar.2006.08.062
Saavedra Juan M, Armando Ines, Bregonzio Claudia, Juorio Augusto, Macova Miroslava, et al. 2006. "A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 31 (6) doi:10.1038/sj.npp.1300921
Zhou Jin, Pavel Jaroslav, Macova Miroslava, Yu Zu-Xi, Imboden Hans, et al. 2006. "AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats." Stroke; a journal of cerebral circulation 37 (5) doi:10.1161/01.STR.0000217404.64352.d7
Saavedra Juan M, Benicky Julius, Zhou Jin 2006. "Angiotensin II: multitasking in the brain." Journal of hypertension. Supplement : official journal of the International Society of Hypertension 24 (1) doi:10.1097/01.hjh.0000220418.09021.ee
Saavedra Juan M, Benicky Julius, Zhou Jin 2006. "Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain." Cellular and molecular neurobiology 26 (7-8) doi:10.1007/s10571-006-9009-0
Saavedra Juan M, Pavel Jaroslav 2006. "The discovery of a novel macrophage binding site." Cellular and molecular neurobiology 26 (4-6) doi:10.1007/s10571-006-9044-x

2005

Zhou Jin, Ando Hiromichi, Macova Miroslava, Dou Jingtao, Saavedra Juan M 2005. "Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 25 (7) doi:10.1038/sj.jcbfm.9600082
Saavedra Juan M, Ando Hiromichi, Armando Inés, Baiardi Gustavo, Bregonzio Claudia, et al. 2005. "Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists." Regulatory peptides 128 (3) doi:10.1016/j.regpep.2004.12.015
Saavedra Juan M 2005. "Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities." Cellular and molecular neurobiology 25 (3-4) doi:10.1007/s10571-005-4011-5
Baiardi Gustavo, Macova Miroslava, Armando Ines, Ando Hiromichi, Tyurmin Dmitri, Saavedra Juan M 2005. "Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat." Regulatory peptides 124 (1-3) doi:10.1016/j.regpep.2004.06.021

2004

Seltzer Alicia, Bregonzio Claudia, Armando Inés, Baiardi Gustavo, Saavedra Juan M 2004. "Oral administration of an AT1 receptor antagonist prevents the central effects of angiotensin II in spontaneously hypertensive rats." Brain research 1028 (1) doi:10.1016/j.brainres.2004.06.079
Martínez Alfredo, Oh Hae-Ryong, Unsworth Edward J, Bregonzio Claudia, Saavedra Juan M, et al. 2004. "Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator." The Biochemical journal 383 (Pt. 3) doi:10.1042/BJ20040920
Ando Hiromichi, Zhou Jin, Macova Miroslava, Imboden Hans, Saavedra Juan M 2004. "Angiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats." Stroke; a journal of cerebral circulation 35 (7) doi:10.1161/01.STR.0000129788.26346.18
Tjurmina Olga A, Armando Ines, Saavedra Juan M, Li Qian, Murphy Dennis L 2004. "Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress." Annals of the New York Academy of Sciences 1018 doi:10.1196/annals.1296.011
Baiardi Gustavo, Bregonzio Claudia, Jezova Miroslava, Armando Ines, Saavedra Juan M 2004. "Angiotensin II AT1 receptor blockade prolongs the lifespan of spontaneously hypertensive rats and reduces stress-induced release of catecholamines, glucocorticoids, and vasopressin." Annals of the New York Academy of Sciences 1018 doi:10.1196/annals.1296.015
Ando Hiromichi, Jezova Miroslava, Zhou Jin, Saavedra Juan M 2004. "Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain." Annals of the New York Academy of Sciences 1018 doi:10.1196/annals.1296.043
Jain Paul, Armando Ines, Juorio Augusto V, Barden Nicholas, Benicky Julius, Saavedra Juan M 2004. "Decreased hypothalamic and adrenal angiotensin II receptor expression and adrenomedullary catecholamines in transgenic mice with impaired glucocorticoid receptor function." Neuroendocrinology 80 (3) doi:10.1159/000082358

2003

Hoe Kwang-Lae, Armando Ines, Baiardi Gustavo, Sreenath Taduru, Kulkarni Ashok, et al. 2003. "Molecular cloning, characterization, and distribution of the gerbil angiotensin II AT2 receptor." American journal of physiology. Regulatory, integrative and comparative physiology 285 (6) doi:10.1152/ajpregu.00008.2003
Armando Ines, Seltzer Alicia, Bregonzio Claudia, Saavedra Juan M 2003. "Stress and angiotensin II: novel therapeutic opportunities." Current drug targets. CNS and neurological disorders 2 (6) doi:
Bregonzio Claudia, Armando Ines, Ando Hiromichi, Jezova Miroslava, Baiardi Gustavo, Saavedra Juan M 2003. "Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury." American journal of physiology. Gastrointestinal and liver physiology 285 (2) doi:10.1152/ajpgi.00058.2003
Jezova Miroslava, Armando Ines, Bregonzio Claudia, Yu Zu-Xi, Qian Sujuan, et al. 2003. "Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription." Endocrinology 144 (5) doi:
Yamakawa Haruki, Phillips M Ian, Saavedra Juan M 2003. "Intracisternal administration of Angiotensin II AT1 receptor antisense oligodeoxynucleotides protects against cerebral ischemia in spontaneously hypertensive rats." Regulatory peptides 111 (1-3) doi:
Yamakawa Haruki, Jezova Miroslava, Ando Hiromichi, Saavedra Juan M 2003. "Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 23 (3) doi:
de Boer Rudolf A, Pinto Yigal M, Suurmeijer Albert J H, Pokharel Saraswati, Scholtens Egbert, et al. 2003. "Increased expression of cardiac angiotensin II type 1 (AT(1)) receptors decreases myocardial microvessel density after experimental myocardial infarction." Cardiovascular research 57 (2) doi:

2002

Tjurmina Olga A, Armando Ines, Saavedra Juan M, Goldstein David S, Murphy Dennis L 2002. "Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene." Endocrinology 143 (12) doi:
Armando Ines, Jezova Miroslava, Juorio Augusto V, Terrón José A, Falcón-Neri Alicia, et al. 2002. "Estrogen upregulates renal angiotensin II AT(2) receptors." American journal of physiology. Renal physiology 283 (5) doi:10.1152/ajprenal.00145.2002
Armando Inés, Terrón José A, Falcón-Neri Alicia, Takeshi Ito, Häuser Walter, et al. 2002. "Increased angiotensin II AT(1) receptor expression in paraventricular nucleus and hypothalamic-pituitary-adrenal axis stimulation in AT(2) receptor gene disrupted mice." Neuroendocrinology 76 (3) doi:64525
Ito Takeshi, Yamakawa Haruki, Bregonzio Claudia, Terrón José A, Falcón-Neri Alicia, Saavedra Juan M 2002. "Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist." Stroke; a journal of cerebral circulation 33 (9) doi:
Hoe Kwang-Lae, Saavedra Juan M 2002. "Site-directed mutagenesis of the gerbil and human angiotensin II AT(1) receptors identifies amino acid residues attributable to the binding affinity for the nonpeptidic antagonist losartan." Molecular pharmacology 61 (6) doi:

2001

Armando Ines, Carranza Andrea, Nishimura Yasuaki, Barontini Marta, Ito Takeshi, Saavedra Juan M 2001. "Candesartan decreases the sympatho-adrenal and hormonal response to isolation stress." Journal of the renin-angiotensin-aldosterone system : JRAAS 2 (1_suppl) doi:10.1177/14703203010020012301