Lomas David A

Top coauthors of Lomas David A

Silverman Edwin K (59 papers)

Bakke Per (40 papers)

Tal-Singer Ruth (39 papers)

Crowther Damian C (33 papers)

Cho Michael H (32 papers)

List of Lomas David A publications

2018

Tabberer Maggie, Lomas David A, Birk Ruby, Brealey Noushin, Zhu Chang-Qing, et al. 2018. "Once-Daily Triple Therapy in Patients with COPD: Patient-Reported Symptoms and Quality of Life." Advances in therapy doi:10.1007/s12325-017-0650-4

2017

Partridge Frederick A, Brown Anwen E, Buckingham Steven D, Willis Nicky J, Wynne Graham M, et al. 2017. "An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes." International journal for parasitology. Drugs and drug resistance 8 (1) doi:10.1016/j.ijpddr.2017.11.004
Lipson David A, Barnacle Helen, Birk Ruby, Brealey Noushin, Locantore Nicholas, et al. 2017. "FULFIL Trial: Once-Daily Triple Therapy for Patients with Chronic Obstructive Pulmonary Disease." American journal of respiratory and critical care medicine 196 (4) doi:10.1164/rccm.201703-0449OC
Busch Robert, Hobbs Brian D, Zhou Jin, Castaldi Peter J, McGeachie Michael J, et al. 2017. "Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects." American journal of respiratory cell and molecular biology 57 (1) doi:10.1165/rcmb.2016-0331OC
Miranda Elena, Ferrarotti Ilaria, Berardelli Romina, Laffranchi Mattia, Cerea Marta, et al. 2017. "The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization." The FEBS journal 284 (13) doi:10.1111/febs.14111
McDonald Merry-Lynn Noelle, Won Sungho, Mattheisen Manuel, Castaldi Peter J, Cho Michael H, et al. 2017. "Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1." Journal of cachexia, sarcopenia and muscle 8 (3) doi:10.1002/jcsm.12171
Ishii Takeo, Angata Takashi, Wan Emily S, Cho Michael H, Motegi Takashi, et al. 2017. "Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency." Respirology (Carlton, Vic.) 22 (4) doi:10.1111/resp.12952
Hobbs Brian D, de Jong Kim, Lamontagne Maxime, Bossé Yohan, Shrine Nick, et al. 2017. "Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis." Nature genetics 49 (3) doi:10.1038/ng.3752

2016

Roussel Benoit D, Lomas David A, Crowther Damian C 2016. "Progressive myoclonic epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis)." Epileptic disorders : international epilepsy journal with videotape doi:10.1684/epd.2016.0847
Dickens Jennifer A, Ordóñez Adriana, Chambers Joseph E, Beckett Alison J, Patel Vruti, et al. 2016. "The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin." FASEB journal : official publication of the Federation of American Societies for Experimental Biology doi:10.1096/fj.201600430R
Tabberer Maggie, Gonzalez-McQuire Sebastian, Muellerova Hana, Briggs Andrew, Rutten-van Molken Maureen, et al. 2016. "Development of a Conceptual Model of Disease Progression for Use in Economic Modeling of Chronic Obstructive Pulmonary Disease." Medical decision making : an international journal of the Society for Medical Decision Making doi:10.1177/0272989X16662009
Lomas David A 2016. "An ECLIPSE View of Alpha-1 Antitrypsin Deficiency." Annals of the American Thoracic Society 13 (Supplement_4) doi:10.1513/AnnalsATS.201506-348KV
Motamedi-Shad Neda, Jagger Alistair M, Liedtke Maximilian, Faull Sarah V, Nanda Arjun Scott, et al. 2016. "An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour." The Biochemical journal doi:10.1042/BCJ20160159
Briggs Andrew, Baker Timothy, Risebrough Nancy A, Chambers Mike, Gonzalez-McQuire Sebastian, et al. 2016. "Development of the Galaxy Chronic Obstructive Pulmonary Disease (COPD) Model Using Data from ECLIPSE: Internal Validation of a Linked-Equations Cohort Model." Medical decision making : an international journal of the Society for Medical Decision Making doi:10.1177/0272989X16653118
Lomas David A 2016. "Does Protease-Antiprotease Imbalance Explain Chronic Obstructive Pulmonary Disease?" Annals of the American Thoracic Society 13 (Supplement_2) doi:10.1513/AnnalsATS.201504-196KV
Lomas David A, Hurst John R, Gooptu Bibek 2016. "Update on alpha-1 antitrypsin deficiency: new therapies." Journal of hepatology doi:10.1016/j.jhep.2016.03.010
Rabinovich Roberto A, Miller Bruce E, Wrobel Karolina, Ranjit Kareshma, Williams Michelle C, et al. 2016. "Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD." The European respiratory journal doi:10.1183/13993003.01824-2015
Hobbs Brian D, Parker Margaret M, Chen Han, Lao Taotao, Hardin Megan, et al. 2016. "Exome Array Analysis Identifies A Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease." American journal of respiratory and critical care medicine doi:10.1164/rccm.201510-2053OC
Haq Imran, Irving James A, Saleh Aarash D, Dron Louis, Regan-Mochrie Gemma L, et al. 2016. "Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization." American journal of respiratory cell and molecular biology 54 (1) doi:10.1165/rcmb.2015-0154OC
Greene Catherine M, Marciniak Stefan J, Teckman Jeffrey, Ferrarotti Ilaria, Brantly Mark L, et al. 2016. "α1-Antitrypsin deficiency." Nature reviews. Disease primers 2 doi:10.1038/nrdp.2016.51

2015

Moriconi Claudia, Ordoñez Adriana, Lupo Giuseppe, Gooptu Bibek, Irving James A, et al. 2015. "Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum." The FEBS journal 282 (23) doi:10.1111/febs.13517
Exuzides Alex, Colby Chris, Briggs Andrew, Lomas David A, Rutten van-Mölken Maureen, et al. 2015. "Statistical Modeling of Disease Progression for Chronic Obstructive Pulmonary Disease Using Data from the ECLIPSE Study." Medical decision making : an international journal of the Society for Medical Decision Making doi:10.1177/0272989X15610781
Yonchuk John G, Silverman Edwin K, Bowler Russell P, Agustí Alvar, Lomas David A, et al. 2015. "Circulating soluble receptor for advanced glycation end products (sRAGE) as a biomarker of emphysema and the RAGE axis in the lung." American journal of respiratory and critical care medicine 192 (7) doi:10.1164/rccm.201501-0137PP
Nyon Mun Peak, Prentice Tanya, Day Jemma, Kirkpatrick John, Sivalingam Ganesh N, et al. 2015. "An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding." Protein science : a publication of the Protein Society 24 (8) doi:10.1002/pro.2706
Ordóñez Adriana, Pérez Juan, Tan Lu, Dickens Jennifer A, Motamedi-Shad Neda, et al. 2015. "A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29 (6) doi:10.1096/fj.14-267351
Irving James A, Miranda Elena, Haq Imran, Perez Juan, Kotov Vadim R, et al. 2015. "An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein." The Biochemical journal 468 (1) doi:10.1042/BJ20141569
Wilson Andrew A, Ying Lei, Liesa Marc, Segeritz Charis-Patricia, Mills Jason A, et al. 2015. "Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells." Stem cell reports 4 (5) doi:10.1016/j.stemcr.2015.02.021
Wilke Sarah, Jones Paul W, Müllerova H, Vestbo Jørgen, Tal-Singer Ruth, et al. 2015. "One-year change in health status and subsequent outcomes in COPD." Thorax 70 (5) doi:10.1136/thoraxjnl-2014-205697
Wan Emily S, Qiu Weiliang, Morrow Jarrett, Beaty Terri H, Hetmanski Jacqueline, et al. 2015. "Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome." Molecular reproduction and development 82 (5) doi:10.1002/mrd.22483
Rennard Stephen I, Locantore Nicholas, Delafont Bruno, Tal-Singer Ruth, Silverman Edwin K, et al. 2015. "Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis." Annals of the American Thoracic Society 12 (3) doi:10.1513/AnnalsATS.201403-125OC
Lee Jin Hwa, Cho Michael H, Hersh Craig P, McDonald Merry-Lynn N, Wells J Michael, et al. 2015. "IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease." American journal of respiratory cell and molecular biology 52 (3) doi:10.1165/rcmb.2014-0210OC
Castaldi Peter J, Cho Michael H, Zhou Xiaobo, Qiu Weiliang, Mcgeachie Michael, et al. 2015. "Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci." Human molecular genetics 24 (4) doi:10.1093/hmg/ddu525
Van't Wout Emily F A, van Schadewijk Annemarie, Lomas David A, Stolk Jan, Marciniak Stefan J, Hiemstra Pieter S 2015. "Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency." The European respiratory journal 45 (2) doi:10.1183/09031936.00046114
Mannino David M, Tal-Singer Ruth, Lomas David A, Vestbo Jorgen, Graham Barr R, et al. 2015. "Plasma Fibrinogen as a Biomarker for Mortality and Hospitalized Exacerbations in People with COPD." Chronic obstructive pulmonary diseases (Miami, Fla.) 2 (1) doi:10.15326/jcopdf.2.1.2014.0138
Dijkstra Akkelies E, Smolonska Joanna, van den Berge Maarten, Wijmenga Ciska, Zanen Pieter, et al. 2015. "Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study." PloS one 10 (5) doi:10.1371/journal.pone.0129524
Lutz Sharon M, Cho Michael H, Young Kendra, Hersh Craig P, Castaldi Peter J, et al. 2015. "A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry." BMC genetics 16 doi:10.1186/s12863-015-0299-4
Dijkstra Akkelies E, Boezen H Marike, van den Berge Maarten, Vonk Judith M, Hiemstra Pieter S, et al. 2015. "Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD." The European respiratory journal 45 (1) doi:10.1183/09031936.00093314
Tan Lu, Perez Juan, Mela Marianna, Miranda Elena, Burling Keith A, et al. 2015. "Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody." The international journal of biochemistry & cell biology 58 doi:10.1016/j.biocel.2014.11.005

2014

McDonald Merry-Lynn N, Cho Michael H, Sørheim Inga-Cecilie, Lutz Sharon M, Castaldi Peter J, et al. 2014. "Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease." American journal of respiratory cell and molecular biology 51 (5) doi:10.1165/rcmb.2014-0135OC
Mohan Divya, Gale Nichola S, McEniery Carmel M, Bolton Charlotte E, Cockcroft John R, et al. 2014. "Evaluating the role of inflammation in chronic airways disease: the ERICA study." COPD 11 (5) doi:10.3109/15412555.2014.898031
Williams Michelle C, Murchison John T, Edwards Lisa D, Agustí Alvar, Bakke Per, et al. 2014. "Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality." Thorax 69 (8) doi:10.1136/thoraxjnl-2012-203151
Faner Rosa, Tal-Singer Ruth, Riley John H, Celli Bartolomé, Vestbo Jørgen, et al. 2014. "Lessons from ECLIPSE: a review of COPD biomarkers." Thorax 69 (7) doi:10.1136/thoraxjnl-2013-204778
Irving James A, Haq Imran, Dickens Jennifer A, Faull Sarah V, Lomas David A 2014. "Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization." The Biochemical journal 460 (1) doi:10.1042/BJ20131650
Vestbo Jørgen, Agusti Alvar, Wouters Emiel F M, Bakke Per, Calverley Peter M A, et al. 2014. "Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team." American journal of respiratory and critical care medicine 189 (9) doi:10.1164/rccm.201311-2006PP
Chen Ko-Fan, Possidente Bernard, Lomas David A, Crowther Damian C 2014. "The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease." Disease models & mechanisms 7 (4) doi:10.1242/dmm.014134
Tan Lu, Dickens Jennifer A, Demeo Dawn L, Miranda Elena, Perez Juan, et al. 2014. "Circulating polymers in α1-antitrypsin deficiency." The European respiratory journal doi:10.1183/09031936.00111213
Marciniak Stefan J, Lomas David A 2014. "Genetic susceptibility." Clinics in chest medicine 35 (1) doi:10.1016/j.ccm.2013.10.008
Cho Michael H, McDonald Merry-Lynn N, Zhou Xiaobo, Mattheisen Manuel, Castaldi Peter J, et al. 2014. "Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis." The Lancet. Respiratory medicine 2 (3) doi:10.1016/S2213-2600(14)70002-5
McDonald Merry-Lynn N, Diaz Alejandro A, Ross James C, San Jose Estepar Raul, Zhou Linfu, et al. 2014. "Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study." Annals of the American Thoracic Society 11 (3) doi:10.1513/AnnalsATS.201307-229OC
van 't Wout Emily F A, Dickens Jennifer A, van Schadewijk Annemarie, Haq Imran, Kwok Hang Fai, et al. 2014. "Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin." Human molecular genetics 23 (4) doi:10.1093/hmg/ddt487
Gooptu Bibek, Dickens Jennifer A, Lomas David A 2014. "The molecular and cellular pathology of α₁-antitrypsin deficiency." Trends in molecular medicine 20 (2) doi:10.1016/j.molmed.2013.10.007
Dijkstra Akkelies E, Smolonska Joanna, van den Berge Maarten, Wijmenga Ciska, Zanen Pieter, et al. 2014. "Susceptibility to chronic mucus hypersecretion, a genome wide association study." PloS one 9 (4) doi:10.1371/journal.pone.0091621
Lee Jin Hwa, McDonald Merry-Lynn N, Cho Michael H, Wan Emily S, Castaldi Peter J, et al. 2014. "DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease." Respiratory research 15 doi:10.1186/s12931-014-0097-y
Khabirova Eleonora, Moloney Aileen, Marciniak Stefan J, Williams Julie, Lomas David A, et al. 2014. "The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans." PloS one 9 (7) doi:10.1371/journal.pone.0102985
Lee Jin Hwa, Cho Michael H, Hersh Craig P, McDonald Merry-Lynn N, Crapo James D, et al. 2014. "Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease." Respiratory research 15 doi:10.1186/s12931-014-0113-2
Pini Laura, Tiberio Laura, Venkatesan Narayanan, Bezzi Michela, Corda Luciano, et al. 2014. "The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency." Respiratory research 15 doi:10.1186/s12931-014-0112-3

2013

Kruppa Antonina J, Ott Stanislav, Chandraratna Dhia S, Irving James A, Page Richard M, et al. 2013. "Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity." Biochimica et biophysica acta 1832 (12) doi:10.1016/j.bbadis.2013.07.019
Cheng Donavan T, Kim Deog Kyeom, Cockayne Debra A, Belousov Anton, Bitter Hans, et al. 2013. "Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 188 (8) doi:10.1164/rccm.201302-0247OC
Miller Joy, Edwards Lisa D, Agustí Alvar, Bakke Per, Calverley Peter M A, et al. 2013. "Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort." Respiratory medicine 107 (9) doi:10.1016/j.rmed.2013.05.001
Zheng Donghang, Chen Hao, Bartee Mee Y, Williams Jennifer, Davids Jennifer A, et al. 2013. "Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice." Journal of cancer science & therapy 5 doi:10.4172/1948-5956.1000219
Roussel Benoit D, Newton Timothy M, Malzer Elke, Simecek Nikol, Haq Imran, et al. 2013. "Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB." Human molecular genetics doi:10.1093/hmg/ddt310
Chen Hao, Zheng Donghang, Abbott Jeff, Liu Liying, Bartee Mee Y, et al. 2013. "Myxomavirus-derived Serpin Prolongs Survival and Reduces Inflammation and Hemorrhage in an Unrelated Lethal Mouse Viral Infection." Antimicrobial agents and chemotherapy doi:10.1128/AAC.02594-12
Agusti Alvar, Edwards Lisa D, Celli Bartolomé, Macnee William, Calverley Peter M A, et al. 2013. "Characteristics, stability and outcomes of the gold 2011 copd groups in the eclipse cohort." The European respiratory journal doi:10.1183/09031936.00195212
Casaburi Richard, Celli Bartolome, Crapo James, Criner Gerard, Croxton Thomas, et al. 2013. "The COPD Biomarker Qualification Consortium (CBQC)." COPD 10 (3) doi:10.3109/15412555.2012.752807
Haq Imran, Irving James A, Faull Sarah V, Dickens Jennifer A, Ordóñez Adriana, et al. 2013. "Reactive centre loop mutants of alpha-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerisation pathway." Bioscience reports doi:10.1042/BSR20130038
Ordóñez Adriana, Snapp Erik L, Tan Lu, Miranda Elena, Marciniak Stefan J, Lomas David A 2013. "Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1 -antitrypsin deficiency." Hepatology (Baltimore, Md.) 57 (5) doi:10.1002/hep.26173
Zhou Xiaobo, Qiu Weiliang, Sathirapongsasuti J Fah, Cho Michael H, Mancini John D, et al. 2013. "Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells." Genomics 101 (5) doi:10.1016/j.ygeno.2013.02.010
Siedlinski Mateusz, Tingley Dustin, Lipman Peter J, Cho Michael H, Litonjua Augusto A, et al. 2013. "Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility." Human genetics 132 (4) doi:10.1007/s00439-012-1262-3
Coxson Harvey O, Dirksen Asger, Edwards Lisa D, Yates Julie C, Agusti Alvar, et al. 2013. "The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study." The Lancet. Respiratory medicine 1 (2) doi:10.1016/S2213-2600(13)70006-7
Thomas Sally E, Malzer Elke, Ordóñez Adriana, Dalton Lucy E, van 't Wout Emily F A, et al. 2013. "p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress." The Journal of biological chemistry 288 (11) doi:10.1074/jbc.M112.424655
Malzer Elke, Szajewska-Skuta Malgorzata, Dalton Lucy E, Thomas Sally E, Hu Nan, et al. 2013. "Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development." Journal of cell science 126 (Pt 6) doi:10.1242/jcs.117614
Dawwas Muhammad F, Davies Susan E, Griffiths William J H, Lomas David A, Alexander Graeme J 2013. "Prevalence and risk factors for liver involvement in individuals with PiZZ-related lung disease." American journal of respiratory and critical care medicine 187 (5) doi:10.1164/rccm.201204-0739OC
Schipanski Angela, Lange Sascha, Segref Alexandra, Gutschmidt Aljona, Lomas David A, et al. 2013. "A novel interaction between aging and ER overload in a protein conformational dementia." Genetics 193 (3) doi:10.1534/genetics.112.149088
Lomas David A 2013. "Twenty years of polymers: a personal perspective on alpha-1 antitrypsin deficiency." COPD 10 Suppl 1 doi:10.3109/15412555.2013.764401
Polkey Michael I, Spruit Martijn A, Edwards Lisa D, Watkins Michael L, Pinto-Plata Victor, et al. 2013. "Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization." American journal of respiratory and critical care medicine 187 (4) doi:10.1164/rccm.201209-1596OC
Roussel Benoit D, Kruppa Antonina J, Miranda Elena, Crowther Damian C, Lomas David A, Marciniak Stefan J 2013. "Endoplasmic reticulum dysfunction in neurological disease." Lancet neurology 12 (1) doi:10.1016/S1474-4422(12)70238-7
Hansel Nadia N, Ruczinski Ingo, Rafaels Nicholas, Sin Don D, Daley Denise, et al. 2013. "Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD." Human genetics 132 (1) doi:10.1007/s00439-012-1219-6
Aminuddin Farzian, Hackett Tillie-Louise, Stefanowicz Dorota, Saferali Aabida, Paré Peter D, et al. 2013. "Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease." BMC pulmonary medicine 13 doi:10.1186/1471-2466-13-64
Rutten Erica P A, Calverley Peter M A, Casaburi Richard, Agusti Alvar, Bakke Per, et al. 2013. "Changes in body composition in patients with chronic obstructive pulmonary disease: do they influence patient-related outcomes?" Annals of nutrition & metabolism 63 (3) doi:10.1159/000353211

2012

Kim Deog Kyeom, Cho Michael H, Hersh Craig P, Lomas David A, Miller Bruce E, et al. 2012. "Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 186 (12) doi:10.1164/rccm.201206-1013OC
Wan Emily S, Qiu Weiliang, Baccarelli Andrea, Carey Vincent J, Bacherman Helene, et al. 2012. "Systemic steroid exposure is associated with differential methylation in chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 186 (12) doi:10.1164/rccm.201207-1280OC
Ubhi Baljit K, Cheng Kian Kai, Dong Jiyang, Janowitz Tobias, Jodrell Duncan, et al. 2012. "Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD." Molecular bioSystems 8 (12) doi:10.1039/c2mb25194a
Wilk Jemma B, Shrine Nick R G, Loehr Laura R, Zhao Jing Hua, Manichaikul Ani, et al. 2012. "Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction." American journal of respiratory and critical care medicine 186 (7) doi:10.1164/rccm.201202-0366OC
Ubhi Baljit K, Riley John H, Shaw Paul A, Lomas David A, Tal-Singer Ruth, et al. 2012. "Metabolic profiling detects biomarkers of protein degradation in COPD patients." The European respiratory journal 40 (2) doi:10.1183/09031936.00112411
Stolk Jan, Stockley Robert A, Stoel Berend C, Cooper Brendan G, Piitulainen Eeva, et al. 2012. "Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor." The European respiratory journal 40 (2) doi:10.1183/09031936.00161911
Albert Paul, Agusti Alvar, Edwards Lisa, Tal-Singer Ruth, Yates Julie, et al. 2012. "Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease." Thorax 67 (8) doi:10.1136/thoraxjnl-2011-201458
Bafadhel Mona, McKenna Susan, Terry Sarah, Mistry Vijay, Pancholi Mitesh, et al. 2012. "Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial." American journal of respiratory and critical care medicine 186 (1) doi:10.1164/rccm.201108-1553OC
Wan Emily S, Qiu Weiliang, Baccarelli Andrea, Carey Vincent J, Bacherman Helene, et al. 2012. "Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome." Human molecular genetics 21 (13) doi:10.1093/hmg/dds135
Duvoix Annelyse, Dickens Jenny, Haq Imran, Mannino David, Miller Bruce, et al. 2012. "Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease." Thorax doi:10.1136/thoraxjnl-2012-201871
Speretta Elena, Jahn Thomas R, Tartaglia Gian Gaetano, Favrin Giorgio, Barros Teresa P, et al. 2012. "Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity." The Journal of biological chemistry 287 (24) doi:10.1074/jbc.M112.350124
Celli Bartolome R, Locantore Nicholas, Yates Julie, Tal-Singer Ruth, Miller Bruce E, et al. 2012. "Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 185 (10) doi:10.1164/rccm.201110-1792OC
Nyon Mun Peak, Segu Lakshmi, Cabrita Lisa D, Lévy Géraldine R, Kirkpatrick John, et al. 2012. "Structural dynamics associated with intermediate formation in an archetypal conformational disease." Structure (London, England : 1993) 20 (3) doi:10.1016/j.str.2012.01.012
Spruit Martijn A, Polkey Michael I, Celli Bartolome, Edwards Lisa D, Watkins Michael L, et al. 2012. "Predicting outcomes from 6-minute walk distance in chronic obstructive pulmonary disease." Journal of the American Medical Directors Association 13 (3) doi:10.1016/j.jamda.2011.06.009
Lomas David A, Lipson David A, Miller Bruce E, Willits Lisa, Keene Oliver, et al. 2012. "An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease." Journal of clinical pharmacology 52 (3) doi:10.1177/0091270010397050
Qiu Weiliang, Baccarelli Andrea, Carey Vincent J, Boutaoui Nadia, Bacherman Helene, et al. 2012. "Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function." American journal of respiratory and critical care medicine 185 (4) doi:10.1164/rccm.201108-1382OC
Cho Michael H, Castaldi Peter J, Wan Emily S, Siedlinski Mateusz, Hersh Craig P, et al. 2012. "A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13." Human molecular genetics 21 (4) doi:10.1093/hmg/ddr524
Kumita Janet R, Helmfors Linda, Williams Jocy, Luheshi Leila M, Menzer Linda, et al. 2012. "Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26 (1) doi:10.1096/fj.11-185983
Rashid S Tamir, Lomas David A 2012. "Stem cell-based therapy for α₁-antitrypsin deficiency." Stem cell research & therapy 3 (1) doi:10.1186/scrt95
Agustí Alvar, Edwards Lisa D, Rennard Stephen I, MacNee William, Tal-Singer Ruth, et al. 2012. "Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype." PloS one 7 (5) doi:10.1371/journal.pone.0037483

2011

Patschull Anathe O M, Segu Lakshmi, Nyon Mun Peak, Lomas David A, Nobeli Irene, et al. 2011. "Therapeutic target-site variability in α1-antitrypsin characterized at high resolution." Acta crystallographica. Section F, Structural biology and crystallization communications 67 (Pt 12) doi:10.1107/S1744309111040267
Brehm John M, Hagiwara Koichi, Tesfaigzi Yohannes, Bruse Shannon, Mariani Thomas J, et al. 2011. "Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease." Thorax 66 (12) doi:10.1136/thoraxjnl-2011-200017
Castaldi Peter J, Cho Michael H, Litonjua Augusto A, Bakke Per, Gulsvik Amund, et al. 2011. "The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility." American journal of respiratory cell and molecular biology 45 (6) doi:10.1165/rcmb.2011-0055OC
Yusa Kosuke, Rashid S Tamir, Strick-Marchand Helene, Varela Ignacio, Liu Pei-Qi, et al. 2011. "Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells." Nature 478 (7369) doi:10.1038/nature10424
Roussel Benoit D, Irving James A, Ekeowa Ugo I, Belorgey Didier, Haq Imran, et al. 2011. "Unravelling the twists and turns of the serpinopathies." The FEBS journal 278 (20) doi:10.1111/j.1742-4658.2011.08201.x
Siedlinski Mateusz, Cho Michael H, Bakke Per, Gulsvik Amund, Lomas David A, et al. 2011. "Genome-wide association study of smoking behaviours in patients with COPD." Thorax 66 (10) doi:10.1136/thoraxjnl-2011-200154
Vestbo Jørgen, Edwards Lisa D, Scanlon Paul D, Yates Julie C, Agusti Alvar, et al. 2011. "Changes in forced expiratory volume in 1 second over time in COPD." The New England journal of medicine 365 (13) doi:10.1056/NEJMoa1105482
Bafadhel Mona, McKenna Susan, Terry Sarah, Mistry Vijay, Reid Carlene, et al. 2011. "Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers." American journal of respiratory and critical care medicine 184 (6) doi:10.1164/rccm.201104-0597OC
Wan Emily S, Cho Michael H, Boutaoui Nadia, Klanderman Barbara J, Sylvia Jody S, et al. 2011. "Genome-wide association analysis of body mass in chronic obstructive pulmonary disease." American journal of respiratory cell and molecular biology 45 (2) doi:10.1165/rcmb.2010-0294OC
Kohlhoff Kai J, Jahn Thomas R, Lomas David A, Dobson Christopher M, Crowther Damian C, Vendruscolo Michele 2011. "The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster." Integrative biology : quantitative biosciences from nano to macro 3 (7) doi:10.1039/c0ib00149j
Lipman Peter J, Cho Michael H, Bakke Per, Gulsvik Amund, Kong Xiangyang, et al. 2011. "On the follow-up of genome-wide association studies: an overall test for the most promising SNPs." Genetic epidemiology 35 (5) doi:10.1002/gepi.20578
Hersh Craig P, Silverman Edwin K, Gascon Jody, Bhattacharya Soumyaroop, Klanderman Barbara J, et al. 2011. "SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development." American journal of respiratory and critical care medicine 183 (11) doi:10.1164/rccm.201010-1751OC
Sin Don D, Miller Bruce E, Duvoix Annelyse, Man S F Paul, Zhang Xuekui, et al. 2011. "Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 183 (9) doi:10.1164/rccm.201008-1220OC
Jahn Thomas R, Kohlhoff Kai J, Scott Michael, Tartaglia Gian Gaetano, Lomas David A, et al. 2011. "Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease." Journal of neuroscience methods 197 (1) doi:10.1016/j.jneumeth.2011.01.026
Duvoix Annelyse, Miranda Elena, Perez Juan, Sorensen Grith L, Holmskov Uffe, et al. 2011. "Evaluation of full-length, cleaved and nitrosylated serum surfactant protein D as biomarkers for COPD." COPD 8 (2) doi:10.3109/15412555.2011.558542
Ekeowa Ugo I, Marciniak Stefan J, Lomas David A 2011. "α(1)-antitrypsin deficiency and inflammation." Expert review of clinical immunology 7 (2) doi:10.1586/eci.10.95
Foreman Marilyn G, Kong Xiangyang, DeMeo Dawn L, Pillai Sreekumar G, Hersh Craig P, et al. 2011. "Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease." American journal of respiratory cell and molecular biology 44 (3) doi:10.1165/rcmb.2009-0360OC
Rodríguez-González Raquel, Millán Mónica, Sobrino Tomás, Miranda Elena, Brea David, et al. 2011. "The natural tissue plasminogen activator inhibitor neuroserpin and acute ischaemic stroke outcome." Thrombosis and haemostasis 105 (3) doi:10.1160/TH10-09-0621
Belorgey Didier, Irving James A, Ekeowa Ugo I, Freeke Joanna, Roussel Benoit D, et al. 2011. "Characterisation of serpin polymers in vitro and in vivo." Methods (San Diego, Calif.) 53 (3) doi:10.1016/j.ymeth.2010.11.008
Liu Beinan, Moloney Aileen, Meehan Sarah, Morris Kyle, Thomas Sally E, et al. 2011. "Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation." The Journal of biological chemistry 286 (6) doi:10.1074/jbc.M110.158980
Screaton Nicholas J, Miller Fiona N A C, Patel Bipen D, Groves Ashley, Tasker Angela D, et al. 2011. "The clinical impact of high resolution computed tomography in patients with respiratory disease." European radiology 21 (2) doi:10.1007/s00330-010-1923-3
Qiu Weiliang, Cho Michael H, Riley John H, Anderson Wayne H, Singh Dave, et al. 2011. "Genetics of sputum gene expression in chronic obstructive pulmonary disease." PloS one 6 (9) doi:10.1371/journal.pone.0024395
Dickens Jennifer A, Miller Bruce E, Edwards Lisa D, Silverman Edwin K, Lomas David A, Tal-Singer Ruth 2011. "COPD association and repeatability of blood biomarkers in the ECLIPSE cohort." Respiratory research 12 doi:10.1186/1465-9921-12-146
Dickens Jennifer A, Lomas David A 2011. "Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis." Drug design, development and therapy 5 doi:10.2147/DDDT.S14018
Irving James A, Ekeowa Ugo I, Belorgey Didier, Haq Imran, Gooptu Bibek, et al. 2011. "The serpinopathies studying serpin polymerization in vivo." Methods in enzymology 501 doi:10.1016/B978-0-12-385950-1.00018-3
Rodríguez-González Raquel, Sobrino Tomás, Rodríguez-Yáñez Manuel, Millán Mónica, Brea David, et al. 2011. "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke." Journal of translational medicine 9 doi:10.1186/1479-5876-9-58
Kong Xiangyang, Cho Michael H, Anderson Wayne, Coxson Harvey O, Muller Nestor, et al. 2011. "Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema." American journal of respiratory and critical care medicine 183 (1) doi:10.1164/rccm.201004-0541OC

2010

Pillai Sreekumar G, Kong Xiangyang, Edwards Lisa D, Cho Michael H, Anderson Wayne H, et al. 2010. "Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 182 (12) doi:10.1164/rccm.201002-0151OC
Sørheim Inga-Cecilie, Bakke Per, Gulsvik Amund, Pillai Sreekumar G, Johannessen Ane, et al. 2010. "α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts." Chest 138 (5) doi:10.1378/chest.10-0746
Ekeowa Ugo I, Freeke Joanna, Miranda Elena, Gooptu Bibek, Bush Matthew F, et al. 2010. "Defining the mechanism of polymerization in the serpinopathies." Proceedings of the National Academy of Sciences of the United States of America 107 (40) doi:10.1073/pnas.1004785107
Hurst John R, Vestbo Jørgen, Anzueto Antonio, Locantore Nicholas, Müllerova Hana, et al. 2010. "Susceptibility to exacerbation in chronic obstructive pulmonary disease." The New England journal of medicine 363 (12) doi:10.1056/NEJMoa0909883
Rashid S Tamir, Corbineau Sebastien, Hannan Nick, Marciniak Stefan J, Miranda Elena, et al. 2010. "Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells." The Journal of clinical investigation 120 (9) doi:10.1172/JCI43122
Hersh Craig P, Pillai Sreekumar G, Zhu Guohua, Lomas David A, Bakke Per, et al. 2010. "Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene." American journal of respiratory and critical care medicine 182 (5) doi:10.1164/rccm.200910-1586OC
Miranda Elena, Pérez Juan, Ekeowa Ugo I, Hadzic Nedim, Kalsheker Noor, et al. 2010. "A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency." Hepatology (Baltimore, Md.) 52 (3) doi:10.1002/hep.23760
Malzer Elke, Daly Marie-Louise, Moloney Aileen, Sendall Timothy J, Thomas Sally E, et al. 2010. "Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response." Journal of cell science 123 (Pt 17) doi:10.1242/jcs.070078
Brorsson Ann-Christin, Bolognesi Benedetta, Tartaglia Gian Gaetano, Shammas Sarah L, Favrin Giorgio, et al. 2010. "Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide." Biophysical journal 98 (8) doi:10.1016/j.bpj.2009.12.4320
Moloney Aileen, Sattelle David B, Lomas David A, Crowther Damian C 2010. "Alzheimer's disease: insights from Drosophila melanogaster models." Trends in biochemical sciences 35 (4) doi:10.1016/j.tibs.2009.11.004
Cho Michael H, Boutaoui Nadia, Klanderman Barbara J, Sylvia Jody S, Ziniti John P, et al. 2010. "Variants in FAM13A are associated with chronic obstructive pulmonary disease." Nature genetics 42 (3) doi:10.1038/ng.535
Munuswamy-Ramanujam Ganesh, Dai Erbin, Liu Liying, Shnabel Mira, Sun Yun Ming, et al. 2010. "Neuroserpin, a thrombolytic serine protease inhibitor (serpin), blocks transplant vasculopathy with associated modification of T-helper cell subsets." Thrombosis and haemostasis 103 (3) doi:10.1160/TH09-07-0441
Luheshi Leila M, Hoyer Wolfgang, de Barros Teresa Pereira, van Dijk Härd Iris, Brorsson Ann-Christin, et al. 2010. "Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo." PLoS biology 8 (3) doi:10.1371/journal.pbio.1000334
Belorgey Didier, Hägglöf Peter, Onda Maki, Lomas David A 2010. "pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; implications for the control of beta-sheet A and polymerization." Protein science : a publication of the Protein Society 19 (2) doi:10.1002/pro.299
Agusti Alvar, Calverley Peter M A, Celli Bartolome, Coxson Harvey O, Edwards Lisa D, et al. 2010. "Characterisation of COPD heterogeneity in the ECLIPSE cohort." Respiratory research 11 doi:10.1186/1465-9921-11-122

2009

Camp Pat G, Coxson Harvey O, Levy Robert D, Pillai Sreekumar G, Anderson Wayne, et al. 2009. "Sex differences in emphysema and airway disease in smokers." Chest 136 (6) doi:10.1378/chest.09-0676
Chiou Albert, Hägglöf Peter, Orte Angel, Chen Allen Yuyin, Dunne Paul D, et al. 2009. "Probing neuroserpin polymerization and interaction with amyloid-beta peptides using single molecule fluorescence." Biophysical journal 97 (8) doi:10.1016/j.bpj.2009.07.057
DeMeo Dawn L, Mariani Thomas, Bhattacharya Soumyaroop, Srisuma Sorachai, Lange Christoph, et al. 2009. "Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene." American journal of human genetics 85 (4) doi:10.1016/j.ajhg.2009.09.004
Hersh Craig P, Hansel Nadia N, Barnes Kathleen C, Lomas David A, Pillai Sreekumar G, et al. 2009. "Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema." American journal of respiratory cell and molecular biology 41 (3) doi:10.1165/rcmb.2008-0427OC
Kroeger Heike, Miranda Elena, MacLeod Ian, Pérez Juan, Crowther Damian C, et al. 2009. "Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins." The Journal of biological chemistry 284 (34) doi:10.1074/jbc.M109.027102
Davies Mark J, Miranda Elena, Roussel Benoit D, Kaufman Randal J, Marciniak Stefan J, Lomas David A 2009. "Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response." The Journal of biological chemistry 284 (27) doi:10.1074/jbc.M109.010744
Zhu Guohua, Gulsvik Amund, Bakke Per, Ghatta Srinivas, Anderson Wayne, et al. 2009. "Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease." Human molecular genetics 18 (11) doi:10.1093/hmg/ddp111
Ekeowa Ugo I, Gooptu Bibek, Belorgey Didier, Hägglöf Peter, Karlsson-Li Susanna, et al. 2009. "alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies." Clinical science (London, England : 1979) 116 (12) doi:10.1042/CS20080484
Takehara Sayaka, Onda Maki, Zhang Juan, Nishiyama Mika, Yang Xiaoyan, et al. 2009. "The 2.1-A crystal structure of native neuroserpin reveals unique structural elements that contribute to conformational instability." Journal of molecular biology 388 (1) doi:10.1016/j.jmb.2009.03.007
Gooptu Bibek, Miranda Elena, Nobeli Irene, Mallya Meera, Purkiss Andrew, et al. 2009. "Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design." Journal of molecular biology 387 (4) doi:10.1016/j.jmb.2009.01.069
Rival Thomas, Page Richard M, Chandraratna Dhianjali S, Sendall Timothy J, Ryder Edward, et al. 2009. "Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease." The European journal of neuroscience 29 (7) doi:10.1111/j.1460-9568.2009.06701.x
Pillai Sreekumar G, Ge Dongliang, Zhu Guohua, Kong Xiangyang, Shianna Kevin V, et al. 2009. "A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci." PLoS genetics 5 (3) doi:10.1371/journal.pgen.1000421
Gooptu Bibek, Lomas David A 2009. "Conformational pathology of the serpins: themes, variations, and therapeutic strategies." Annual review of biochemistry 78 doi:10.1146/annurev.biochem.78.082107.133320
Lucas Alexandra, Liu Liying, Dai Erbin, Bot Ilze, Viswanathan Kasinath, et al. 2009. "The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics." Advances in experimental medicine and biology 666 doi:

2008

Patel Bipen D, Coxson Harvey O, Pillai Sreekumar G, Agustí Alvar G N, Calverley Peter M A, et al. 2008. "Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 178 (5) doi:10.1164/rccm.200801-059OC
Gooptu Bibek, Lomas David A 2008. "Polymers and inflammation: disease mechanisms of the serpinopathies." The Journal of experimental medicine 205 (7) doi:10.1084/jem.20072080
Miranda Elena, MacLeod Ian, Davies Mark J, Pérez Juan, Römisch Karin, et al. 2008. "The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB." Human molecular genetics 17 (11) doi:10.1093/hmg/ddn041
Marciniak Stefan J, Lomas David A 2008. "Intracellular serpins, firewalls and tissue necrosis." Trends in cell biology 18 (2) doi:10.1016/j.tcb.2007.11.006
Davies Mark J, Lomas David A 2008. "The molecular aetiology of the serpinopathies." The international journal of biochemistry & cell biology 40 (6-7) doi:10.1016/j.biocel.2007.12.017

2007

Mallya Meera, Phillips Russell L, Saldanha S Adrian, Gooptu Bibek, Brown Sarah C Leigh, et al. 2007. "Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates." Journal of medicinal chemistry 50 (22) doi:10.1021/jm070687z
Luheshi Leila M, Tartaglia Gian Gaetano, Brorsson Ann-Christin, Pawar Amol P, Watson Ian E, et al. 2007. "Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity." PLoS biology 5 (11) doi:10.1371/journal.pbio.0050290
Zhu Guohua, Warren Liling, Aponte Jennifer, Gulsvik Amund, Bakke Per, et al. 2007. "The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations." American journal of respiratory and critical care medicine 176 (2) doi:10.1164/rccm.200611-1723OC
Kennedy Sarah A, van Diepen Angela C, van den Hurk Cecilia M, Coates Leigh C, Lee Tet Woo, et al. 2007. "Expression of the serine protease inhibitor neuroserpin in cells of the human myeloid lineage." Thrombosis and haemostasis 97 (3) doi:
Belorgey Didier, Hägglöf Peter, Karlsson-Li Susanna, Lomas David A 2007. "Protein misfolding and the serpinopathies." Prion 1 (1) doi:

2006

Kinghorn Kerri J, Crowther Damian C, Sharp Lynda K, Nerelius Charlotte, Davis Richard L, et al. 2006. "Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease." The Journal of biological chemistry 281 (39) doi:10.1074/jbc.M600690200
Robertson Andrew S, Belorgey Didier, Gubb David, Dafforn Timothy R, Lomas David A 2006. "Inhibitory activity of the Drosophila melanogaster serpin Necrotic is dependent on lysine residues in the D-helix." The Journal of biological chemistry 281 (36) doi:10.1074/jbc.M606085200
Lomas David A 2006. "Parker B. Francis lectureship. Antitrypsin deficiency, the serpinopathies, and chronic obstructive pulmonary disease." Proceedings of the American Thoracic Society 3 (6) doi:10.1513/pats.200603-069MS
Sharp Lynda K, Mallya Meera, Kinghorn Kerri J, Wang Zhen, Crowther Damian C, et al. 2006. "Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis." The FEBS journal 273 (11) doi:10.1111/j.1742-4658.2006.05262.x
Lomas David A 2006. "The selective advantage of alpha1-antitrypsin deficiency." American journal of respiratory and critical care medicine 173 (10) doi:10.1164/rccm.200511-1797PP
Crowther Damian C, Page Richard, Chandraratna Dhianjali, Lomas David A 2006. "A Drosophila model of Alzheimer's disease." Methods in enzymology 412 doi:10.1016/S0076-6879(06)12015-7

2005

Onda Maki, Belorgey Didier, Sharp Lynda K, Lomas David A 2005. "Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies." The Journal of biological chemistry 280 (14) doi:10.1074/jbc.M413282200
Mahadeva Ravi, Atkinson Carl, Li Zhenjun, Stewart Susan, Janciauskiene Sabina, et al. 2005. "Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo." The American journal of pathology 166 (2) doi:
Lomas David A 2005. "Molecular mousetraps, alpha1-antitrypsin deficiency and the serpinopathies." Clinical medicine (London, England) 5 (3) doi:

2004

Janciauskiene Sabina, Eriksson Sten, Callea Francesco, Mallya Meera, Zhou Aiwu, et al. 2004. "Differential detection of PAS-positive inclusions formed by the Z, Siiyama, and Mmalton variants of alpha1-antitrypsin." Hepatology (Baltimore, Md.) 40 (5) doi:10.1002/hep.20451
Crowther Damian C, Kinghorn Kerri J, Page Richard, Lomas David A 2004. "Therapeutic targets from a Drosophila model of Alzheimer's disease." Current opinion in pharmacology 4 (5) doi:10.1016/j.coph.2004.07.001
Zhou Aiwu, Stein Penelope E, Huntington James A, Sivasothy Pasupathy, Lomas David A, Carrell Robin W 2004. "How small peptides block and reverse serpin polymerisation." Journal of molecular biology 342 (3) doi:10.1016/j.jmb.2004.07.078
Lomas David A, Belorgey Didier, Mallya Meera, Onda Maki, Kinghorn Kerri J, et al. 2004. "Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies." Frontiers in bioscience : a journal and virtual library 9 doi:
Belorgey Didier, Sharp Lynda K, Crowther Damian C, Onda Maki, Johansson Jan, Lomas David A 2004. "Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB." European journal of biochemistry / FEBS 271 (16) doi:10.1111/j.1432-1033.2004.04270.x
Parfrey Helen, Dafforn Timothy R, Belorgey Didier, Lomas David A, Mahadeva Ravi 2004. "Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema." American journal of respiratory cell and molecular biology 31 (2) doi:10.1165/rcmb.2003-0276OC
Miranda Elena, Römisch Karin, Lomas David A 2004. "Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum." The Journal of biological chemistry 279 (27) doi:10.1074/jbc.M313166200
Crowther Damian C, Belorgey Didier, Miranda Elena, Kinghorn Kerri J, Sharp Lynda K, Lomas David A 2004. "Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies." European journal of human genetics : EJHG 12 (3) doi:10.1038/sj.ejhg.5201127
Chow Michelle K M, Lomas David A, Bottomley Stephen P 2004. "Promiscuous beta-strand interactions and the conformational diseases." Current medicinal chemistry 11 (4) doi:

2003

Parfrey Helen, Mahadeva Ravi, Ravenhill Neil A, Zhou Aiwu, Dafforn Timothy R, et al. 2003. "Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease." The Journal of biological chemistry 278 (35) doi:10.1074/jbc.M302646200
Parfrey Helen, Mahadeva Ravi, Lomas David A 2003. "Alpha(1)-antitrypsin deficiency, liver disease and emphysema." The international journal of biochemistry & cell biology 35 (7) doi:
Green Clare, Brown Gemma, Dafforn Timothy R, Reichhart Jean-Marc, Morley Terri, et al. 2003. "Drosophila necrotic mutations mirror disease-associated variants of human serpins." Development (Cambridge, England) 130 (7) doi:
Crowther Damian C, Serpell Louise C, Dafforn Timothy R, Gooptu Bibek, Lomas David A 2003. "Nucleation of alpha 1-antichymotrypsin polymerization." Biochemistry 42 (8) doi:10.1021/bi0259305
Robertson Andrew S, Belorgey Didier, Lilley Kathryn S, Lomas David A, Gubb David, Dafforn Timothy R 2003. "Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila." The Journal of biological chemistry 278 (8) doi:10.1074/jbc.M209277200

2002

Lomas David A, Carrell Robin W 2002. "Serpinopathies and the conformational dementias." Nature reviews. Genetics 3 (10) doi:10.1038/nrg907
Davis Richard L, Shrimpton Antony E, Carrell Robin W, Lomas David A, Gerhard Lieselotte, et al. 2002. "Association between conformational mutations in neuroserpin and onset and severity of dementia." Lancet 359 (9325) doi:10.1016/S0140-6736(02)09293-0
Parmar Jasvir S, Mahadeva Ravi, Reed Benjamin J, Farahi Neda, Cadwallader Karen A, et al. 2002. "Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema." American journal of respiratory cell and molecular biology 26 (6) doi:10.1165/ajrcmb.26.6.4739
Belorgey Didier, Crowther Damian C, Mahadeva Ravi, Lomas David A 2002. "Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro." The Journal of biological chemistry 277 (19) doi:10.1074/jbc.M200680200
Mahadeva Ravi, Dafforn Timothy R, Carrell Robin W, Lomas David A 2002. "6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis." The Journal of biological chemistry 277 (9) doi:10.1074/jbc.C100722200