LeRoith Derek

Top coauthors of LeRoith Derek

Yakar Shoshana (41 papers)

Gallagher Emily J (15 papers)

Gallagher Emily Jane (10 papers)

Gavrilova Oksana (9 papers)

Sun Hui (9 papers)

List of LeRoith Derek publications

2017

Leiter Amanda, Bickell Nina A, LeRoith Derek, Nayak Anupma, Feldman Sheldon M, et al. 2017. "Statin Use and Breast Cancer Prognosis in Black and White Women." Hormones & cancer doi:10.1007/s12672-017-0312-7
Mosa Rasha, Huang Lili, Wu Yeda, Fung Chungyan, Mallawakankanamalage Oshini, et al. 2017. "Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice." Endocrinology 158 (10) doi:10.1210/en.2017-00168
Shlomai Gadi, Zelenko Zara, Antoniou Irini Markella, Stasinopoulos Marilyn, Tobin-Hess Aviva, et al. 2017. "OP449 inhibits breast cancer growth without adverse metabolic effects." Endocrine-related cancer 24 (10) doi:10.1530/ERC-17-0077
Mosa Rasha, Huang Lili, Li Hongzhuo, Grist Michael, LeRoith Derek, Chen Chen 2017. "Long-term treatment with the ghrelin receptor antagonist, [D-Lys3]-GHRP-6 does not improve glucose homeostasis in non-obese diabetic MKR mice." American journal of physiology. Regulatory, integrative and comparative physiology doi:10.1152/ajpregu.00157.2017
Qiang Xiaoling, Liotta Anthony S, Shiloach Joseph, Gutierrez J C, Wang Haichao, et al. 2017. "New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut." NPJ biofilms and microbiomes 3 doi:10.1038/s41522-017-0039-9
Ben-Shmuel Sarit, Rashed Rola, Rostoker Ran, Isakov Elina, Shen-Orr Zila, LeRoith Derek 2017. "Activating Transcription Factor-5 Knockdown Reduces Aggressiveness of Mammary Tumor Cells and Attenuates Mammary Tumor Growth." Frontiers in endocrinology 8 doi:10.3389/fendo.2017.00173

2016

Shlomai Gadi, Neel Brian, LeRoith Derek, Gallagher Emily Jane 2016. "Type 2 Diabetes Mellitus and Cancer: The Role of Pharmacotherapy." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34 (35) doi:10.1200/JCO.2016.67.4044
Pollack Rena M, Donath Marc Y, LeRoith Derek, Leibowitz Gil 2016. "Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications." Diabetes care 39 Suppl 2 doi:10.2337/dcS15-3015
Zelenko Zara, Gallagher Emily Jane, Antoniou Irini Markella, Sachdev D, Nayak Anupma, et al. 2016. "EMT Reversal in human cancer cells after IR knockdown in hyperinsulinemic mice." Endocrine-related cancer doi:10.1530/ERC-16-0142
Handelsman Yehuda, Henry Robert R, Bloomgarden Zachary T, Dagogo-Jack Sam, DeFronzo Ralph A, et al. 2016. "AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS." Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists doi:10.4158/EP161292.PS
Gallagher Emily J, Zelenko Zara, Tobin-Hess Aviva, Werner Ulrich, Tennagels Norbert, LeRoith Derek 2016. "Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes." Diabetologia doi:10.1007/s00125-016-4000-x
Gallagher Emily J, LeRoith Derek, Stasinopoulos Marilyn, Zelenko Zara, Shiloach Joseph 2016. "Polyol accumulation in muscle and liver in a mouse model of type 2 diabetes." Journal of diabetes and its complications doi:10.1016/j.jdiacomp.2016.04.019
Lubitz Irit, Ricny Jan, Atrakchi-Baranes Dana, Shemesh Chen, Kravitz Efrat, et al. 2016. "High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model." Aging cell 15 (2) doi:10.1111/acel.12436
Gallagher Emily J, LeRoith Derek, Franco Rebeca, Antoniou Irini Markella, Nayak Anupma, et al. 2016. "Metabolic syndrome and pre-diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways." Diabetes/metabolism research and reviews doi:10.1002/dmrr.2795
Rhee John Y, Bahtila Tumi Divine, Palmer Dennis, Tih Pius Muffih, Aberg Judith A, et al. 2016. "Prevalence of and factors associated with prediabetes and diabetes among HIV-infected adults in Cameroon." Diabetes/metabolism research and reviews doi:10.1002/dmrr.2792
Werner Haim, Sarfstein Rive, LeRoith Derek, Bruchim Ilan 2016. "Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways." Frontiers in oncology 6 doi:10.3389/fonc.2016.00159
Rostoker Ran, Ben-Shmuel Sarit, Rashed Rola, Shen Orr Zila, LeRoith Derek 2016. "CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy." Breast cancer research : BCR 18 (1) doi:10.1186/s13058-016-0711-7
Ben-Shmuel Sarit, Rostoker Ran, Scheinman Eyal J, LeRoith Derek 2016. "Metabolic Syndrome, Type 2 Diabetes, and Cancer: Epidemiology and Potential Mechanisms." Handbook of experimental pharmacology 233 doi:10.1007/164_2015_12

2015

Ben-Shmuel Sarit, Scheinman Eyal J, Rashed Rola, Orr Zila Shen, Gallagher Emily J, et al. 2015. "Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice." The Journal of endocrinology 227 (3) doi:10.1530/JOE-15-0310
Akrivos Jimmy, Ravona-Springer Ramit, Schmeidler James, LeRoith Derek, Heymann Anthony, et al. 2015. "Glycemic control, inflammation, and cognitive function in older patients with type 2 diabetes." International journal of geriatric psychiatry 30 (10) doi:10.1002/gps.4267
Rostoker Ran, Jayaprakash Anitha D, Sachidanandam Ravi, LeRoith Derek 2015. "Deep sequencing of mRNA in CD24(-) and CD24(+) mammary carcinoma Mvt1 cell line." Genomics data 5 doi:10.1016/j.gdata.2015.06.032
Jao Jennifer, Kirmse Brian, Yu Chunli, Qiu Yunping, Powis Kathleen, et al. 2015. "Lower Preprandial Insulin and Altered Fuel Use in HIV/Antiretroviral-Exposed Infants in Cameroon." The Journal of clinical endocrinology and metabolism 100 (9) doi:10.1210/JC.2015-2198
Gallagher Emily Jane, LeRoith Derek 2015. "Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality." Physiological reviews 95 (3) doi:10.1152/physrev.00030.2014
Scheinman Eyal J, Damouni Rawan, Caspi Avishay, Shen-Orr Zila, Tiosano Dov, LeRoith Derek 2015. "The beneficial effect of growth hormone treatment on islet mass in streptozotocin-treated mice." Diabetes/metabolism research and reviews 31 (5) doi:10.1002/dmrr.2631
Rostoker Ran, Abelson Sagi, Bitton-Worms Keren, Genkin Inna, Ben-Shmuel Sarit, et al. 2015. "Highly specific role of the insulin receptor in breast cancer progression." Endocrine-related cancer 22 (2) doi:10.1530/ERC-14-0490
Handelsman Yehuda, Bloomgarden Zachary T, Grunberger George, Umpierrez Guillermo, Zimmerman Robert S, et al. 2015. "AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY - CLINICAL PRACTICE GUIDELINES FOR DEVELOPING A DIABETES MELLITUS COMPREHENSIVE CARE PLAN - 2015." Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 21 Suppl 1 doi:10.4158/EP15672.GLSUPPL
Lin Jenny J, Gallagher Emily J, Sigel Keith, Mhango Grace, Galsky Matthew D, et al. 2015. "Survival of patients with stage IV lung cancer with diabetes treated with metformin." American journal of respiratory and critical care medicine 191 (4) doi:10.1164/rccm.201407-1395OC
Rostoker Ran, Abelson Sagi, Genkin Inna, Ben-Shmuel Sarit, Sachidanandam Ravi, et al. 2015. "CD24(+) cells fuel rapid tumor growth and display high metastatic capacity." Breast cancer research : BCR 17 doi:10.1186/s13058-015-0589-9

2014

Werner Haim, LeRoith Derek 2014. "Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects." European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 24 (12) doi:10.1016/j.euroneuro.2014.01.020
Stewart Morag H, Gutierrez-Martinez Paula, Beerman Isabel, Garrison Brian, Gallagher Emily J, et al. 2014. "Growth hormone receptor signaling is dispensable for HSC function and aging." Blood 124 (20) doi:10.1182/blood-2014-05-575308
Cefalu William T, Nair K Sreekumaran, Seaquist Elizabeth R, Zierath Juleen, Boulton Andrew J M, et al. 2014. "Statement of Principle." The Journal of clinical endocrinology and metabolism doi:10.1210/jc.2014-3958
Cefalu William T, Nair K Sreekumaran, Seaquist Elizabeth R, Zierath Juleen, Boulton Andrew J M, et al. 2014. "Statement of Principle." Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists doi:10.4158/EP11314.STMNT
Rota Lauren M, Albanito Lidia, Shin Marcus E, Goyeneche Corey L, Shushanov Sain, et al. 2014. "IGF1R inhibition in mammary epithelia promotes canonical Wnt signaling and Wnt1-driven tumors." Cancer research 74 (19) doi:10.1158/0008-5472.CAN-14-0970
Cefalu William T, Buse John B, Del Prato Stefano, Home Philip D, LeRoith Derek, et al. 2014. "Beyond metformin: safety considerations in the decision-making process for selecting a second medication for type 2 diabetes management: reflections from a diabetes care editors' expert forum." Diabetes care 37 (9) doi:10.2337/dc14-1395
Mallipattu Sandeep K, Gallagher Emily J, LeRoith Derek, Liu Ruijie, Mehrotra Anita, et al. 2014. "Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus." American journal of physiology. Renal physiology 306 (9) doi:10.1152/ajprenal.00597.2013
Gallagher Emily Jane, Sun Hui, Kornhauser Caroline, Tobin-Hess Aviva, Epstein Sol, et al. 2014. "The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes." Diabetes/metabolism research and reviews 30 (3) doi:10.1002/dmrr.2466
Kumar Amit, Harrelson Thomas, Lewis Nathan E, Gallagher Emily J, LeRoith Derek, et al. 2014. "Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice." PloS one 9 (7) doi:10.1371/journal.pone.0102319

2013

Belardi Valentina, Gallagher Emily J, Novosyadlyy Ruslan, LeRoith Derek 2013. "Insulin and IGFs in obesity-related breast cancer." Journal of mammary gland biology and neoplasia 18 (3-4) doi:10.1007/s10911-013-9303-7
Gallagher Emily J, LeRoith Derek 2013. "Diabetes, antihyperglycemic medications and cancer risk: smoke or fire?" Current opinion in endocrinology, diabetes, and obesity 20 (5) doi:10.1097/01.med.0000433065.16918.83
Bechmann Lars P, Vetter Diana, Ishida Junichi, Hannivoort Rebekka A, Lang Ursula E, et al. 2013. "Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis." Journal of hepatology 58 (5) doi:10.1016/j.jhep.2013.01.020
Rostoker Ran, Bitton-Worms Keren, Caspi Avishay, Shen-Orr Zila, LeRoith Derek 2013. "Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model." Endocrinology 154 (5) doi:10.1210/en.2012-2263
Ferguson Rosalyn D, Gallagher Emily J, Scheinman Eyal J, Damouni Rawan, LeRoith Derek 2013. "The epidemiology and molecular mechanisms linking obesity, diabetes, and cancer." Vitamins and hormones 93 doi:10.1016/B978-0-12-416673-8.00010-1

2012

Cohen Dara Hope, LeRoith Derek 2012. "Obesity, type 2 diabetes, and cancer: the insulin and IGF connection." Endocrine-related cancer 19 (5) doi:10.1530/ERC-11-0374
Rota Lauren M, Lazzarino Deborah A, Ziegler Amber N, LeRoith Derek, Wood Teresa L 2012. "Determining mammosphere-forming potential: application of the limiting dilution analysis." Journal of mammary gland biology and neoplasia 17 (2) doi:10.1007/s10911-012-9258-0
Lam David W, LeRoith Derek 2012. "The worldwide diabetes epidemic." Current opinion in endocrinology, diabetes, and obesity 19 (2) doi:10.1097/MED.0b013e328350583a
Vijayakumar Archana, Wu YingJie, Buffin Nicholas J, Li Xiaosong, Sun Hui, et al. 2012. "Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation." PloS one 7 (9) doi:10.1371/journal.pone.0044777
Dankner Rachel, Balicer Ran, Boffetta Paolo, Boker Lital Keinan, Wallenstein Sylvan, et al. 2012. "Diabetes, glucose control, glucose lowering medications, and cancer risk: a 10-year population-based historical cohort." BMC cancer 12 doi:10.1186/1471-2407-12-364
Periyasamy-Thandavan Sudharsan, Takhar Suchreet, Singer Adam, Dohn Michael Robert, Jackson William Hutch, et al. 2012. "Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim." Breast cancer research : BCR 14 (2) doi:10.1186/bcr3153
Vijayakumar Archana, Wu YingJie, Sun Hui, Li Xiaosong, Jeddy Zuha, et al. 2012. "Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration." Diabetes 61 (1) doi:10.2337/db11-0814

2011

Gallagher Emily Jane, LeRoith Derek 2011. "Diabetes, cancer, and metformin: connections of metabolism and cell proliferation." Annals of the New York Academy of Sciences 1243 doi:10.1111/j.1749-6632.2011.06285.x
Sun Zhaoyu, Shushanov Sain, LeRoith Derek, Wood Teresa L 2011. "Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2." Endocrinology 152 (8) doi:10.1210/en.2010-1296
Gallagher Emily J, LeRoith Derek 2011. "Minireview: IGF, Insulin, and Cancer." Endocrinology 152 (7) doi:10.1210/en.2011-0231
Tamler Ronald, Green Dina E, Skamagas Maria, Breen Tracy L, Looker Helen C, LeRoith Derek 2011. "Effect of case-based training for medical residents on confidence, knowledge, and management of inpatient glycemia." Postgraduate medicine 123 (4) doi:10.3810/pgm.2011.07.2309
Wu Yingjie, Liu Chengyu, Sun Hui, Vijayakumar Archana, Giglou Pejman Raeisi, et al. 2011. "Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice." The Journal of clinical investigation 121 (6) doi:10.1172/JCI45027
Gallagher Emily Jane, LeRoith Derek 2011. "Is growth hormone resistance/IGF-1 reduction good for you?" Cell metabolism 13 (4) doi:10.1016/j.cmet.2011.03.003
Li Xiaosong, Wu Xhiping, Camacho Raul, Schwartz Gary J, LeRoith Derek 2011. "Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms." PloS one 6 (2) doi:10.1371/journal.pone.0017058
Braun Sandra, Bitton-Worms Keren, LeRoith Derek 2011. "The link between the metabolic syndrome and cancer." International journal of biological sciences 7 (7) doi:

2010

Fierz Yvonne, Novosyadlyy Ruslan, Vijayakumar Archana, Yakar Shoshana, LeRoith Derek 2010. "Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes." Endocrine-related cancer 17 (4) doi:10.1677/ERC-10-0091
LeRoith Derek 2010. "Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models." Diabetes/metabolism research and reviews 26 (8) doi:10.1002/dmrr.1139
Heron-Milhavet Lisa, Mamaeva Daria, LeRoith Derek, Lamb Ned J, Fernandez Anne 2010. "Impaired muscle regeneration and myoblast differentiation in mice with a muscle-specific KO of IGF-IR." Journal of cellular physiology 225 (1) doi:10.1002/jcp.22218
Gallagher Emily Jane, LeRoith Derek 2010. "The proliferating role of insulin and insulin-like growth factors in cancer." Trends in endocrinology and metabolism: TEM 21 (10) doi:10.1016/j.tem.2010.06.007
Gallagher Emily Jane, LeRoith Derek 2010. "Insulin, insulin resistance, obesity, and cancer." Current diabetes reports 10 (2) doi:10.1007/s11892-010-0101-y
Fierz Yvonne, Novosyadlyy Ruslan, Vijayakumar Archana, Yakar Shoshana, LeRoith Derek 2010. "Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression." Diabetes 59 (3) doi:10.2337/db09-1291
Vijayakumar Archana, Novosyadlyy Ruslan, Wu Yingjie, Yakar Shoshana, LeRoith Derek 2010. "Biological effects of growth hormone on carbohydrate and lipid metabolism." Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20 (1) doi:10.1016/j.ghir.2009.09.002
Novosyadlyy Ruslan, Lann Danielle E, Vijayakumar Archana, Rowzee Anne, Lazzarino Deborah A, et al. 2010. "Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes." Cancer research 70 (2) doi:10.1158/0008-5472.CAN-09-2141
Cannata Dara, Fierz Yvonne, Vijayakumar Archana, LeRoith Derek 2010. "Type 2 diabetes and cancer: what is the connection?" The Mount Sinai journal of medicine, New York 77 (2) doi:10.1002/msj.20167
Gallagher Emily J, Fierz Yvonne, Ferguson Rosalyn D, LeRoith Derek 2010. "The pathway from diabetes and obesity to cancer, on the route to targeted therapy." Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 16 (5) doi:10.4158/EP10098.RA

2009

Wu Yingjie, Sun Hui, Yakar Shoshana, LeRoith Derek 2009. "Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice." Endocrinology 150 (9) doi:10.1210/en.2009-0272
Hong Sung-Hyeok, Briggs Joseph, Newman Rachel, Hoffman Karen, Mendoza Arnulfo, et al. 2009. "Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I." International journal of cancer. Journal international du cancer 124 (9) doi:10.1002/ijc.24169
Kawashima Yuki, Fritton J Christopher, Yakar Shoshana, Epstein Sol, Schaffler Mitchell B, et al. 2009. "Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis." Bone 44 (4) doi:10.1016/j.bone.2008.12.012
Yakar Shoshana, Rosen Clifford J, Bouxsein Mary L, Sun Hui, Mejia Wilson, et al. 2009. "Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23 (3) doi:10.1096/fj.08-118976
Lim Gareth E, Huang Guan J, Flora Nina, LeRoith Derek, Rhodes Christopher J, Brubaker Patricia L 2009. "Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell." Endocrinology 150 (2) doi:10.1210/en.2008-0726
Wu Yingjie, Wang Chunxin, Sun Hui, LeRoith Derek, Yakar Shoshana 2009. "High-efficient FLPo deleter mice in C57BL/6J background." PloS one 4 (11) doi:10.1371/journal.pone.0008054

2008

Toyoshima Yuka, Monson Christopher, Duan Cunming, Wu Yingjie, Gao Chuan, et al. 2008. "The role of insulin receptor signaling in zebrafish embryogenesis." Endocrinology 149 (12) doi:10.1210/en.2008-0329
Radbill Brian, Murphy Barbara, LeRoith Derek 2008. "Rationale and strategies for early detection and management of diabetic kidney disease." Mayo Clinic proceedings. Mayo Clinic 83 (12) doi:10.1016/S0025-6196(11)60786-6
Lann Danielle, LeRoith Derek 2008. "The role of endocrine insulin-like growth factor-I and insulin in breast cancer." Journal of mammary gland biology and neoplasia 13 (4) doi:10.1007/s10911-008-9100-x
Kim Jaetaek, Wende Adam R, Sena Sandra, Theobald Heather A, Soto Jamie, et al. 2008. "Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy." Molecular endocrinology (Baltimore, Md.) 22 (11) doi:10.1210/me.2008-0265
Gallagher Emily Jane, LeRoith Derek, Karnieli Eddy 2008. "The metabolic syndrome--from insulin resistance to obesity and diabetes." Endocrinology and metabolism clinics of North America 37 (3) doi:10.1016/j.ecl.2008.05.002
Anzo Makoto, Cobb Laura J, Hwang David L, Mehta Hemal, Said Jonathan W, et al. 2008. "Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression." Cancer research 68 (9) doi:10.1158/0008-5472.CAN-07-3165
Bentov Itay, Narla Goutham, Schayek Hagit, Akita Kuhihara, Plymate Stephen R, et al. 2008. "Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner." Endocrinology 149 (4) doi:10.1210/en.2007-0844
LeRoith Derek 2008. "Clinical relevance of systemic and local IGF-I: lessons from animal models." Pediatric endocrinology reviews : PER 5 Suppl 2 doi:

2007

Lann Danielle, LeRoith Derek 2007. "Insulin resistance as the underlying cause for the metabolic syndrome." The Medical clinics of North America 91 (6) doi:10.1016/j.mcna.2007.06.012
Inagaki Kenjiro, Tiulpakov Anatoly, Rubtsov Petr, Sverdlova Polina, Peterkova Valentina, et al. 2007. "A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization." The Journal of clinical endocrinology and metabolism 92 (4) doi:10.1210/jc.2006-2354
LeRoith Derek, Yakar Shoshana 2007. "Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1." Nature clinical practice. Endocrinology & metabolism 3 (3) doi:10.1038/ncpendmet0427
Samani Amir Abbas, Yakar Shoshana, LeRoith Derek, Brodt Pnina 2007. "The role of the IGF system in cancer growth and metastasis: overview and recent insights." Endocrine reviews 28 (1) doi:10.1210/er.2006-0001
LeRoith Derek, Rayfield Elliot J 2007. "The benefits of tight glycemic control in type 2 diabetes mellitus." Clinical cornerstone 8 Suppl 7 doi:
LeRoith Derek 2007. "Dyslipidemia and glucose dysregulation in overweight and obese patients." Clinical cornerstone 8 (3) doi:
LeRoith Derek 2007. "Treatment of diabetes: a clinical update on insulin trials." Clinical cornerstone 8 (2) doi:

2006

Yakar Shoshana, Nunez Nomeli P, Pennisi Patricia, Brodt Pnina, Sun Hui, et al. 2006. "Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones." Endocrinology 147 (12) doi:10.1210/en.2006-0311
Kim Chul-Hee, Pennisi Patricia, Zhao Hong, Yakar Shoshana, Kaufman Jeanne B, et al. 2006. "MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness." American journal of physiology. Endocrinology and metabolism 291 (2) doi:10.1152/ajpendo.00319.2005
Xu Xiaoling, Kobayashi Shogo, Qiao Wenhui, Li Cuiling, Xiao Cuiying, et al. 2006. "Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice." The Journal of clinical investigation 116 (7) doi:10.1172/JCI27282
Pennisi Patricia, Gavrilova Oksana, Setser-Portas Jennifer, Jou William, Santopietro Stefania, et al. 2006. "Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus." Endocrinology 147 (6) doi:10.1210/en.2005-1556
LeRoith Derek, Gavrilova Oksana 2006. "Mouse models created to study the pathophysiology of Type 2 diabetes." The international journal of biochemistry & cell biology 38 (5-6) doi:10.1016/j.biocel.2005.01.019

2005

Freedman Renee J, Malkovska Vera, LeRoith Derek, Collins Michael T 2005. "Hodgkin lymphoma in temporal association with growth hormone replacement." Endocrine journal 52 (5) doi:
LeRoith Derek, Smith Deirdre O 2005. "Monitoring glycemic control: the cornerstone of diabetes care." Clinical therapeutics 27 (10) doi:10.1016/j.clinthera.2005.10.010
Toyoshima Yuka, Gavrilova Oksana, Yakar Shoshana, Jou William, Pack Stephanie, et al. 2005. "Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes." Endocrinology 146 (9) doi:10.1210/en.2005-0087
LeRoith Derek, Fonseca Vivian, Vinik Aaron 2005. "Metabolic memory in diabetes--focus on insulin." Diabetes/metabolism research and reviews 21 (2) doi:10.1002/dmrr.530
Yakar Shoshana, Pennisi Patricia, Wu Yiping, Zhao Hong, LeRoith Derek 2005. "Clinical relevance of systemic and local IGF-I." Endocrine development 9 doi:10.1159/000085718

2004

Rose Annabel, Froment Pascal, Perrot Valérie, Quon Michael J, LeRoith Derek, Dupont Joëlle 2004. "The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt." The Journal of biological chemistry 279 (50) doi:10.1074/jbc.M404571200
Lu Yarong, Herrera Pedro L, Guo Yubin, Sun David, Tang Zhengyi, et al. 2004. "Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes." Diabetes 53 (12) doi:
Zhao Hong, Yakar Shoshana, Gavrilova Oksana, Sun Hui, Zhang Yang, et al. 2004. "Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes." Diabetes 53 (11) doi:
Matsusue Kimihiko, Gavrilova Oksana, Lambert Gilles, Brewer H Bryan, Ward Jerrold M, et al. 2004. "Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice." Molecular endocrinology (Baltimore, Md.) 18 (11) doi:10.1210/me.2004-0213
Pennisi Patricia A, Kopchick John J, Thorgeirsson Snorri, LeRoith Derek, Yakar Shoshana 2004. "Role of growth hormone (GH) in liver regeneration." Endocrinology 145 (10) doi:10.1210/en.2004-0655
Héron-Milhavet Lisa, Haluzik Martin, Yakar Shoshana, Gavrilova Oksana, Pack Stephanie, et al. 2004. "Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice." Endocrinology 145 (10) doi:10.1210/en.2003-1543
Zhang Yang, Karas Michael, Zhao Hong, Yakar Shoshana, LeRoith Derek 2004. "14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation." The Journal of biological chemistry 279 (33) doi:10.1074/jbc.M401300200
Toyoshima Yuka, Karas Michael, Yakar Shoshana, Dupont Joelle, Lee Helman, LeRoith Derek 2004. "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival." The Journal of biological chemistry 279 (24) doi:10.1074/jbc.M400661200
Haluzik Martin, Gavrilova Oksana, LeRoith Derek 2004. "Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies." Endocrinology 145 (4) doi:10.1210/en.2003-1015
Héron-Milhavet Lisa, Xue-Jun Yang, Vannucci Susan J, Wood Teresa L, Willing Lisa B, et al. 2004. "Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain." Molecular and cellular neurosciences 25 (4) doi:10.1016/j.mcn.2003.10.012
LeRoith Derek, Helman Lee 2004. "The new kid on the block(ade) of the IGF-1 receptor." Cancer cell 5 (3) doi:
Inoue Hiroshi, Ogawa Wataru, Ozaki Michitaka, Haga Sanae, Matsumoto Michihiro, et al. 2004. "Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo." Nature medicine 10 (2) doi:10.1038/nm980
Zhao Hong, Dupont Joelle, Yakar Shoshana, Karas Michael, LeRoith Derek 2004. "PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells." Oncogene 23 (3) doi:10.1038/sj.onc.1207162
Yakar Shoshana, Pennisi Patricia, Zhao Hong, Zhang Yang, LeRoith Derek 2004. "Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse." Novartis Foundation symposium 262 doi:
Welniak Lisbeth A, Karas Michael, Yakar Shoshana, Anver Miriam R, Murphy William J, LeRoith Derek 2004. "Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 10 (1) doi:10.1016/j.bbmt.2003.09.008
Smith Deirdre O, LeRoith Derek 2004. "Insulin resistance syndrome, pre-diabetes, and the prevention of type 2 diabetes mellitus." Clinical cornerstone 6 (2) doi:
Yakar Shoshana, Setser Jennifer, Zhao Hong, Stannard Bethel, Haluzik Martin, et al. 2004. "Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice." The Journal of clinical investigation 113 (1) doi:10.1172/JCI17763

2003

Haluzik Martin, Yakar Shoshana, Gavrilova Oksana, Setser Jennifer, Boisclair Yves, LeRoith Derek 2003. "Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance." Diabetes 52 (10) doi:
Bentov Itay, LeRoith Derek, Werner Haim 2003. "The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action." Endocrinology 144 (10) doi:10.1210/en.2003-0400
Mejia-Naranjo Wilson, Yakar Shoshana, Bernal Rosalina, LeRoith Derek, Sanchez-Gomez Myriam 2003. "Regulation of the splenic somatotropic axis by dietary protein and insulin-like growth factor-I in the rat." Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 13 (5) doi:
Dupont Joëlle, Karas Michael, LeRoith Derek 2003. "The cyclin-dependent kinase inhibitor p21CIP/WAF is a positive regulator of insulin-like growth factor I-induced cell proliferation in MCF-7 human breast cancer cells." The Journal of biological chemistry 278 (39) doi:10.1074/jbc.M302355200
Wu Yiping, Cui Karen, Miyoshi Keiko, Hennighausen Lothar, Green Jeffrey E, et al. 2003. "Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors." Cancer research 63 (15) doi:
Kim Hyunsook, Haluzik Martin, Asghar Zeenat, Yau Daphne, Joseph Jamie W, et al. 2003. "Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis." Diabetes 52 (7) doi:
Yu Rong, Yakar Shoshana, Liu Ye Lauren, Lu Yarong, LeRoith Derek, et al. 2003. "Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance." Molecular and cellular endocrinology 204 (1-2) doi:
LeRoith Derek, Roberts Charles T 2003. "The insulin-like growth factor system and cancer." Cancer letters 195 (2) doi:
Dupont Joelle, Dunn Sandra E, Barrett J Carl, LeRoith Derek 2003. "Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression." Recent progress in hormone research 58 doi:
Cefalu William T, LeRoith Derek 2003. "Overcoming the barriers for achieving standards of diabetes care: the formation of CADRE." Diabetes technology & therapeutics 5 (3) doi:10.1089/152091503765691884

2002

LeRoith Derek 2002. "Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities." The American journal of medicine 113 Suppl 6A doi:
Yakar Shoshana, Rosen Clifford J, Beamer Wesley G, Ackert-Bicknell Cheryl L, Wu Yiping, et al. 2002. "Circulating levels of IGF-1 directly regulate bone growth and density." The Journal of clinical investigation 110 (6) doi:10.1172/JCI15463
Dupont Joëlle, Renou Jean Pierre, Shani Moshe, Hennighausen Lothar, LeRoith Derek 2002. "PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium." The Journal of clinical investigation 110 (6) doi:10.1172/JCI13829
Héron-Milhavet Lisa, LeRoith Derek 2002. "Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage." The Journal of biological chemistry 277 (18) doi:10.1074/jbc.M111142200
Butler Andrew A, Yakar Shoshana, LeRoith Derek 2002. "Insulin-like growth factor-I: compartmentalization within the somatotropic axis?" News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 17 doi:
Wu Yiping, Yakar Shoshana, Zhao Ling, Hennighausen Lothar, LeRoith Derek 2002. "Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis." Cancer research 62 (4) doi: