Heine R J

Top coauthors of Heine R J

Dekker J M (79 papers)

Bouter L M (72 papers)

Nijpels G (70 papers)

Kostense P J (49 papers)

Snoek F J (39 papers)

List of Heine R J publications

2016

Mast M R, Walraven I, Hoekstra T, Jansen A P Daniëlle, van der Heijden A A, et al. 2016. "Effectiveness of insulin therapy in people with Type 2 diabetes in the Hoorn Diabetes Care System." Diabetic medicine : a journal of the British Diabetic Association doi:10.1111/dme.13110

2014

Guigas B, de Leeuw van Weenen J E, van Leeuwen N, Simonis-Bik A M, van Haeften T W, et al. 2014. "Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility." Diabetic medicine : a journal of the British Diabetic Association 31 (8) doi:10.1111/dme.12464
Fowkes F G R, Murray G D, Butcher I, Folsom A R, Hirsch A T, et al. 2014. "Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events." European journal of preventive cardiology 21 (3) doi:10.1177/2047487313516564

2012

Song X, Pitkäniemi J, Gao W, Heine R J, Pyörälä K, et al. 2012. "Relationship between body mass index and mortality among Europeans." European journal of clinical nutrition 66 (2) doi:10.1038/ejcn.2011.145

2011

Foley J E, Bunck M C, Möller-Goede D L, Poelma M, Nijpels G, et al. 2011. "Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial." Diabetologia 54 (8) doi:10.1007/s00125-011-2167-8
Simonis-Bik A M C, Boomsma D I, Dekker J M, Diamant M, de Geus E J C, et al. 2011. "The heritability of beta cell function parameters in a mixed meal test design." Diabetologia 54 (5) doi:10.1007/s00125-011-2060-5
Pouwer F, Tack C J, Geelhoed-Duijvestijn P H L M, Bazelmans E, Beekman A T, et al. 2011. "Limited effect of screening for depression with written feedback in outpatients with diabetes mellitus: a randomised controlled trial." Diabetologia 54 (4) doi:10.1007/s00125-010-2033-0
Bunck M C, Eliasson B, Cornér A, Heine R J, Shaginian R M, et al. 2011. "Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes." Diabetes, obesity & metabolism 13 (4) doi:10.1111/j.1463-1326.2010.01355.x
Borg R, Kuenen J C, Carstensen B, Zheng H, Nathan D M, et al. 2011. "HbA₁(c) and mean blood glucose show stronger associations with cardiovascular disease risk factors than do postprandial glycaemia or glucose variability in persons with diabetes: the A1C-Derived Average Glucose (ADAG) study." Diabetologia 54 (1) doi:10.1007/s00125-010-1918-2

2010

Zhou X H, Qiao Q, Zethelius B, Pyörälä K, Söderberg S, et al. 2010. "Diabetes, prediabetes and cancer mortality." Diabetologia 53 (9) doi:10.1007/s00125-010-1796-7
Borg R, Kuenen J C, Carstensen B, Zheng H, Nathan D M, et al. 2010. "Real-life glycaemic profiles in non-diabetic individuals with low fasting glucose and normal HbA1c: the A1C-Derived Average Glucose (ADAG) study." Diabetologia 53 (8) doi:10.1007/s00125-010-1741-9
van Bastelaar K M P, Pouwer F, Geelhoed-Duijvestijn P H L M, Tack C J, Bazelmans E, et al. 2010. "Diabetes-specific emotional distress mediates the association between depressive symptoms and glycaemic control in Type 1 and Type 2 diabetes." Diabetic medicine : a journal of the British Diabetic Association 27 (7) doi:10.1111/j.1464-5491.2010.03025.x
Sarwat S, Ilag L L, Carey M A, Shrom D S, Heine R J 2010. "The relationship between self-monitored blood glucose values and glycated haemoglobin in insulin-treated patients with Type 2 diabetes." Diabetic medicine : a journal of the British Diabetic Association 27 (5) doi:10.1111/j.1464-5491.2010.02955.x
Pouwer F, Geelhoed-Duijvestijn P H L M, Tack C J, Bazelmans E, Beekman A-J, et al. 2010. "Prevalence of comorbid depression is high in out-patients with Type 1 or Type 2 diabetes mellitus. Results from three out-patient clinics in the Netherlands." Diabetic medicine : a journal of the British Diabetic Association 27 (2) doi:10.1111/j.1464-5491.2009.02903.x

2009

Simonis-Bik A M C, Eekhoff E M W, de Moor M H M, Kramer M H H, Boomsma D I, et al. 2009. "Genetic influences on the insulin response of the beta cell to different secretagogues." Diabetologia 52 (12) doi:10.1007/s00125-009-1532-3
van Halm V P, Peters M J L, Voskuyl A E, Boers M, Lems W F, et al. 2009. "Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease: a cross-sectional study, the CARRE Investigation." Annals of the rheumatic diseases 68 (9) doi:10.1136/ard.2008.094151
Snijder M B, Flyvbjerg A, Stehouwer C D A, Frystyk J, Henry R M A, et al. 2009. "Relationship of adiposity with arterial stiffness as mediated by adiponectin in older men and women: the Hoorn Study." European journal of endocrinology / European Federation of Endocrine Societies 160 (3) doi:10.1530/EJE-08-0817
Alssema M, Schindhelm R K, Rijkelijkhuizen J M, Kostense P J, Teerlink T, et al. 2009. "Meal composition affects insulin secretion in women with type 2 diabetes: a comparison with healthy controls. The Hoorn prandial study." European journal of clinical nutrition 63 (3) doi:10.1038/sj.ejcn.1602953
Jaakkola U, Kallio J, Heine R J, Nijpels G, T' Hart L M, et al. 2009. "Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study." European journal of clinical nutrition 63 (1) doi:10.1038/sj.ejcn.1602964

2008

Zhang L, Qiao Q, Tuomilehto J, Hammar N, Alberti K G M M, et al. 2008. "Blood lipid levels in relation to glucose status in European men and women without a prior history of diabetes: the DECODE Study." Diabetes research and clinical practice 82 (3) doi:10.1016/j.diabres.2008.08.022
Alssema M, Feskens E J M, Bakker S J L, Gansevoort R T, Boer J M A, et al. 2008. "[Finnish questionnaire reasonably good predictor of the incidence of diabetes in The Netherlands]." Nederlands tijdschrift voor geneeskunde 152 (44) doi:
Snoek F J, van der Ven N C W, Twisk J W R, Hogenelst M H E, Tromp-Wever A M E, et al. 2008. "Cognitive behavioural therapy (CBT) compared with blood glucose awareness training (BGAT) in poorly controlled Type 1 diabetic patients: long-term effects on HbA moderated by depression. A randomized controlled trial." Diabetic medicine : a journal of the British Diabetic Association 25 (11) doi:10.1111/j.1464-5491.2008.02595.x
Groenewoud M J, Dekker J M, Fritsche A, Reiling E, Nijpels G, et al. 2008. "Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps." Diabetologia 51 (9) doi:10.1007/s00125-008-1083-z
Brouwers M C G J, Dekker J M, van Greevenbroek M M J, van der Kallen C J H, Heine R J, et al. 2008. "Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study." Diabetic medicine : a journal of the British Diabetic Association 25 (9) doi:10.1111/j.1464-5491.2008.02524.x
Fowkes F G R, Murray G D, Butcher I, Heald C L, Lee R J, et al. 2008. "Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis." JAMA : the journal of the American Medical Association 300 (2) doi:10.1001/jama.300.2.197
Nijpels G, Boorsma W, Dekker J M, Hoeksema F, Kostense P J, et al. 2008. "Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance." The Journal of clinical endocrinology and metabolism 93 (7) doi:10.1210/jc.2007-2837
Adriaanse M C, Dekker J M, Heine R J, Snoek F J, Beekman A J, et al. 2008. "Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study." Diabetic medicine : a journal of the British Diabetic Association 25 (7) doi:10.1111/j.1464-5491.2008.02464.x
van Deutekom A W, Niessen H W M, Schalkwijk C G, Heine R J, Simsek S 2008. "Increased Nepsilon-(carboxymethyl)-lysine levels in cerebral blood vessels of diabetic patients and in a (streptozotocin-treated) rat model of diabetes mellitus." European journal of endocrinology / European Federation of Endocrine Societies 158 (5) doi:10.1530/EJE-08-0024
Hoogeveen E K, Mackaay A J C, Beks P J, Kostense P J, Dekker J M, et al. 2008. "Evaluation of the one-minute exercise test to detect peripheral arterial disease." European journal of clinical investigation 38 (5) doi:10.1111/j.1365-2362.2008.01946.x
Henry R M A, Paulus W J, Kamp O, Kostense P J, Spijkerman A M W, et al. 2008. "Deteriorating glucose tolerance status is associated with left ventricular dysfunction--the Hoorn Study." The Netherlands journal of medicine 66 (3) doi:
van Deutekom A W, Heine R J, Simsek S 2008. "The islet autoantibody titres: their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus." Diabetic medicine : a journal of the British Diabetic Association 25 (2) doi:10.1111/j.1464-5491.2007.02316.x
Alssema M, Schindhelm R K, Dekker J M, Diamant M, Kostense P J, et al. 2008. "Postprandial glucose and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn prandial study." Atherosclerosis 196 (2) doi:10.1016/j.atherosclerosis.2006.12.021
Nijpels G, Boorsma W, Dekker J M, Kostense P J, Bouter L M, Heine R J 2008. "A study of the effects of acarbose on glucose metabolism in patients predisposed to developing diabetes: the Dutch acarbose intervention study in persons with impaired glucose tolerance (DAISI)." Diabetes/metabolism research and reviews 24 (8) doi:10.1002/dmrr.839

2007

Maassen J A, Romijn J A, Heine R J 2007. "Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus." Diabetologia 50 (10) doi:10.1007/s00125-007-0776-z
Wessels A M, Rombouts S A R B, Remijnse P L, Boom Y, Scheltens P, et al. 2007. "Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume." Diabetologia 50 (8) doi:10.1007/s00125-007-0714-0
Wessels A M, Pouwer F, Geelhoed-Duijvestijn P H L M, Snel M, Kostense P J, et al. 2007. "No evidence for increased self-reported cognitive failure in Type 1 and Type 2 diabetes: a cross-sectional study." Diabetic medicine : a journal of the British Diabetic Association 24 (7) doi:10.1111/j.1464-5491.2007.02153.x
Wentholt I M E, Maran A, Masurel N, Heine R J, Hoekstra J B L, DeVries J H 2007. "Nocturnal hypoglycaemia in Type 1 diabetic patients, assessed with continuous glucose monitoring: frequency, duration and associations." Diabetic medicine : a journal of the British Diabetic Association 24 (5) doi:10.1111/j.1464-5491.2007.02107.x
Schindhelm R K, Dekker J M, Nijpels G, Stehouwer C D A, Bouter L M, et al. 2007. "Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study." Diabetic medicine : a journal of the British Diabetic Association 24 (4) doi:10.1111/j.1464-5491.2007.02100.x
Bos G, Poortvliet M C, Scheffer P G, Dekker J M, Ocke M C, et al. 2007. "Dietary polyunsaturated fat intake is associated with low-density lipoprotein size, but not with susceptibility to oxidation in subjects with impaired glucose metabolism and type II diabetes: the Hoorn study." European journal of clinical nutrition 61 (2) doi:10.1038/sj.ejcn.1602492
Alssema M, Dekker J M, Kuivenhoven J A, Nijpels G, Teerlink T, et al. 2007. "Elevated cholesteryl ester transfer protein concentration is associated with an increased risk for cardiovascular disease in women, but not in men, with Type 2 diabetes: the Hoorn Study." Diabetic medicine : a journal of the British Diabetic Association 24 (2) doi:10.1111/j.1464-5491.2007.02033.x
Danesh J, Erqou S, Walker M, Thompson S G, Tipping R, et al. 2007. "The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases." European journal of epidemiology 22 (12) doi:10.1007/s10654-007-9165-7

2006

Adriaanse M C, Dekker J M, Nijpels G, Heine R J, Snoek F J, Pouwer F 2006. "Associations between depressive symptoms and insulin resistance: the Hoorn Study." Diabetologia 49 (12) doi:10.1007/s00125-006-0500-4
de Galan B E, Simsek S, Tack C J, Heine R J 2006. "Efficacy and safety of inhaled insulin in the treatment of diabetes mellitus." The Netherlands journal of medicine 64 (9) doi:
Wessels A M, Simsek S, Remijnse P L, Veltman D J, Biessels G J, et al. 2006. "Voxel-based morphometry demonstrates reduced grey matter density on brain MRI in patients with diabetic retinopathy." Diabetologia 49 (10) doi:10.1007/s00125-006-0283-7
Welschen L M C, Bloemendal E, Nijpels G, Dekker J M, Heine R J, et al. 2006. "[From the Cochrane Library and Diabetes Care: self-monitoring of blood glucose probably an effective way to improve glycaemic control in patients with type 2 diabetes not taking insulin]." Nederlands tijdschrift voor geneeskunde 150 (33) doi:
Simsek S, Diamant M, Eekhoffen E M W, Heine R J 2006. "[Diabetes mellitus: simple classification and corresponding treatment]." Nederlands tijdschrift voor geneeskunde 150 (18) doi:
Knol M J, Twisk J W R, Beekman A T F, Heine R J, Snoek F J, Pouwer F 2006. "Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis." Diabetologia 49 (5) doi:10.1007/s00125-006-0159-x
Tushuizen M E, Nieuwland R, Scheffer P G, Sturk A, Heine R J, Diamant M 2006. "Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men." Journal of thrombosis and haemostasis : JTH 4 (5) doi:10.1111/j.1538-7836.2006.01914.x
Simsek S, de Galan B E, Tack C J, Heine R J 2006. "[Treatment of patients with diabetes mellitus by means of inhaled insulin]." Nederlands tijdschrift voor geneeskunde 150 (15) doi:
Koppes L L J, Dekker J M, Hendriks H F J, Bouter L M, Heine R J 2006. "Meta-analysis of the relationship between alcohol consumption and coronary heart disease and mortality in type 2 diabetic patients." Diabetologia 49 (4) doi:10.1007/s00125-005-0127-x

2005

Spoelstra-De Man A M E, Smulders Y M, Dekker J M, Heine R J, Bouter L M, et al. 2005. "Homocysteine levels are not associated with cardiovascular autonomic function in elderly Caucasian subjects without or with type 2 diabetes mellitus: the Hoorn Study." Journal of internal medicine 258 (6) doi:10.1111/j.1365-2796.2005.01578.x
Pouwer F, Nijpels G, Beekman A T, Dekker J M, van Dam R M, et al. 2005. "Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids? A review of the evidence." Diabetic medicine : a journal of the British Diabetic Association 22 (11) doi:10.1111/j.1464-5491.2005.01661.x
van der Ven N C W, Hogenelst M H E, Tromp-Wever A M E, Twisk J W R, van der Ploeg H M, et al. 2005. "Short-term effects of cognitive behavioural group training (CBGT) in adult Type 1 diabetes patients in prolonged poor glycaemic control. A randomized controlled trial." Diabetic medicine : a journal of the British Diabetic Association 22 (11) doi:10.1111/j.1464-5491.2005.01691.x
van Hecke M V, Dekker J M, Nijpels G, Moll A C, Heine R J, et al. 2005. "Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study." Diabetologia 48 (7) doi:10.1007/s00125-005-1799-y
Schindhelm R K, Diamant M, Bakker S J L, van Dijk R A J M, Scheffer P G, et al. 2005. "Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus." European journal of clinical investigation 35 (6) doi:10.1111/j.1365-2362.2005.01502.x
Ouwens D M, Boer C, Fodor M, de Galan P, Heine R J, et al. 2005. "Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats." Diabetologia 48 (6) doi:10.1007/s00125-005-1755-x
Scheffer P G, Teerlink T, Heine R J 2005. "Clinical significance of the physicochemical properties of LDL in type 2 diabetes." Diabetologia 48 (5) doi:10.1007/s00125-005-1736-0
Dekker J M, Diamant M, Nijpels G, Heine R J 2005. "[Metabolic syndrome: limited significance for clinical practice]." Nederlands tijdschrift voor geneeskunde 149 (16) doi:
Spijkerman A M W, Smulders Y M, Kostense P J, Henry R M A, Becker A, et al. 2005. "S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study." Arteriosclerosis, thrombosis, and vascular biology 25 (4) doi:10.1161/01.ATV.0000157981.57694.d2
de Bree A, van der Put N M J, Mennen L I, Verschuren W M M, Blom H J, et al. 2005. "Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations." European journal of clinical nutrition 59 (4) doi:10.1038/sj.ejcn.1602097
Tushuizen M E, Diamant M, Heine R J 2005. "Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes." Postgraduate medical journal 81 (951) doi:10.1136/pgmj.2004.020511
Welschen L M C, Bloemendal E, Nijpels G, Dekker J M, Heine R J, et al. 2005. "Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin." Cochrane database of systematic reviews (Online) (2) doi:10.1002/14651858.CD005060.pub2

2004

van Dam R M, Dekker J M, Nijpels G, Stehouwer C D A, Bouter L M, Heine R J 2004. "Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study." Diabetologia 47 (12) doi:10.1007/s00125-004-1573-6
Devries J H, Snoek F J, Heine R J 2004. "Persistent poor glycaemic control in adult Type 1 diabetes. A closer look at the problem." Diabetic medicine : a journal of the British Diabetic Association 21 (12) doi:10.1111/j.1464-5491.2004.01386.x
Spijkerman A M W, Henry R M A, Dekker J M, Nijpels G, Kostense P J, et al. 2004. "Prevalence of macrovascular disease amongst type 2 diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn Screening Study." Journal of internal medicine 256 (5) doi:10.1111/j.1365-2796.2004.01395.x
Adriaanse M C, Dekker J M, Spijkerman A M W, Twisk J W R, Nijpels G, et al. 2004. "Health-related quality of life in the first year following diagnosis of Type 2 diabetes: newly diagnosed patients in general practice compared with screening-detected patients. The Hoorn Screening Study." Diabetic medicine : a journal of the British Diabetic Association 21 (10) doi:10.1111/j.1464-5491.2004.01277.x
Diamant M, Bunck M C M, Heine R J 2004. "[Analogs of glucagon-like peptide-1 (GLP-1): an old concept as a new treatment of patients with diabetes mellitus type 2]." Nederlands tijdschrift voor geneeskunde 148 (39) doi:
Adriaanse M C, Snoek F J, Dekker J M, Spijkerman A M W, Nijpels G, et al. 2004. "No substantial psychological impact of the diagnosis of Type 2 diabetes following targeted population screening: The Hoorn Screening Study." Diabetic medicine : a journal of the British Diabetic Association 21 (9) doi:10.1111/j.1464-5491.2004.01276.x
Stumvoll M, Fritsche A, t'Hart L M, Machann J, Thamer C, et al. 2004. "The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations." Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 112 (5) doi:10.1055/s-2004-817972
Heine R J, Balkau B, Ceriello A, Del Prato S, Horton E S, Taskinen M-R 2004. "What does postprandial hyperglycaemia mean?" Diabetic medicine : a journal of the British Diabetic Association 21 (3) doi:
Scheffer P G, Henry R M A, Wever E J M, van Rooij G J, Bos G, et al. 2004. "LDL oxidative modifications in well- or moderately controlled type 2 diabetes." Diabetes/metabolism research and reviews 20 (4) doi:10.1002/dmrr.461

2003

Renders C M, Valk G D, de Sonnaville J J J, Twisk J, Kriegsman D M W, et al. 2003. "Quality of care for patients with Type 2 diabetes mellitus--a long-term comparison of two quality improvement programmes in the Netherlands." Diabetic medicine : a journal of the British Diabetic Association 20 (10) doi:
Becker A, Henry R M A, Kostense P J, Jakobs C, Teerlink T, et al. 2003. "Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals. The Hoorn Study." Atherosclerosis 169 (2) doi:
Dekker J M, van der Kraan M, Nijpels G, de Vegt F, Kostense P J, et al. 2003. "[Estimate of the number of new patients with type 2 diabetes mellitus in the Netherlands: at least 65,000 per year in the age group of 50 years and above]." Nederlands tijdschrift voor geneeskunde 147 (29) doi:
Scheffer P G, Bos G, Volwater H G F M, Dekker J M, Heine R J, Teerlink T 2003. "Associations of LDL size with in vitro oxidizability and plasma levels of in vivo oxidized LDL in Type 2 diabetic patients." Diabetic medicine : a journal of the British Diabetic Association 20 (7) doi:
Pouwer F, Beekman A T F, Nijpels G, Dekker J M, Snoek F J, et al. 2003. "Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study." Diabetologia 46 (7) doi:10.1007/s00125-003-1124-6
Bos G, Dekker J M, Nijpels G, de Vegt F, Diamant M, et al. 2003. "A combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism--The Hoorn Study." Diabetologia 46 (7) doi:10.1007/s00125-003-1141-5
Nijpels G, Serrée M J, Dekker J M, Heine R J 2003. "[Self-monitoring by patients with type-2 diabetes mellitus one year after initiation: user errors in a quarter of cases]." Nederlands tijdschrift voor geneeskunde 147 (22) doi:
van Dijk R A J M, Bakker S J L, Scheffer P G, Heine R J, Stehouwer C D A 2003. "Associations of metabolic variables with arterial stiffness in type 2 diabetes mellitus: focus on insulin sensitivity and postprandial triglyceridaemia." European journal of clinical investigation 33 (4) doi:
Becker A, van der Does F E E, van Hinsbergh V W M, Heine R J, Bouter L M, Stehouwer C D A 2003. "Improvement of glycaemic control in type 2 diabetes: favourable changes in blood pressure, total cholesterol and triglycerides, but not in HDL cholesterol, fibrinogen, Von Willebrand factor and (pro)insulin." The Netherlands journal of medicine 61 (4) doi:
DeVries J H, Lindholm A, Jacobsen J L, Heine R J, Home P D 2003. "A randomized trial of insulin aspart with intensified basal NPH insulin supplementation in people with Type 1 diabetes." Diabetic medicine : a journal of the British Diabetic Association 20 (4) doi:
Becker A, Kostense P J, Bos G, Heine R J, Dekker J M, et al. 2003. "Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes." Journal of internal medicine 253 (3) doi:
Adriaanse M C, Snoek F J, Dekker J M, Spijkerman A M W, Nijpels G, et al. 2003. "Perceived risk for Type 2 diabetes in participants in a stepwise population-screening programme." Diabetic medicine : a journal of the British Diabetic Association 20 (3) doi:
Becker A, Smulders Y M, Teerlink T, Struys E A, de Meer K, et al. 2003. "S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations." European journal of clinical investigation 33 (1) doi:
Stehouwer M H A, DeVries J H, Lumeij J A E, Adèr H J, Engbers A M S, et al. 2003. "Combined bedtime insulin--daytime sulphonylurea regimen compared with two different daily insulin regimens in type 2 diabetes: effects on HbA1c and hypoglycaemia rate--a randomised trial." Diabetes/metabolism research and reviews 19 (2) doi:10.1002/dmrr.356

2002

Spijkerman A M W, Dekker J M, Nijpels G, Jager A, Kostense P J, et al. 2002. "Impact of diabetes duration and cardiovascular risk factors on mortality in type 2 diabetes: the Hoorn Study." European journal of clinical investigation 32 (12) doi:
van de Poll-Franse L V, Valk G D, Renders C M, Heine R J, van Eijk J T M 2002. "Longitudinal assessment of the development of diabetic polyneuropathy and associated risk factors." Diabetic medicine : a journal of the British Diabetic Association 19 (9) doi:
DeVries J H, Eskes S A, Snoek F J, Pouwer F, Van Ballegooie E, et al. 2002. "Continuous intraperitoneal insulin infusion in patients with 'brittle' diabetes: favourable effects on glycaemic control and hospital stay." Diabetic medicine : a journal of the British Diabetic Association 19 (6) doi:
Adriaanse M C, Snoek F J, Dekker J M, van der Ploeg H M, Heine R J 2002. "Screening for Type 2 diabetes: an exploration of subjects' perceptions regarding diagnosis and procedure." Diabetic medicine : a journal of the British Diabetic Association 19 (5) doi:
Heine R J, Dekker J M 2002. "Beyond postprandial hyperglycaemia: metabolic factors associated with cardiovascular disease." Diabetologia 45 (4) doi:10.1007/s00125-001-0726-0
Rump P, Popp-Snijders C, Heine R J, Hornstra G 2002. "Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids." Diabetologia 45 (3) doi:10.1007/s00125-001-0764-7
Rosendal H, Vondeling H, de Witte L P, Hutubessy R C W, van Beekum W T, Heine R J 2002. "[Initiating insulin therapy in patients with diabetes mellitus type 2: in a transmural setting is at least as effective as in an outpatient setting; a retrospective study with a 4-year follow-up]." Nederlands tijdschrift voor geneeskunde 146 (4) doi:
Becker A, van Hinsbergh V W M, Jager A, Kostense P J, Dekker J M, et al. 2002. "Why is soluble intercellular adhesion molecule-1 related to cardiovascular mortality?" European journal of clinical investigation 32 (1) doi:

2001

Pouwer F, Snoek F J, van der Ploeg H M, Adèr H J, Heine R J 2001. "Monitoring of psychological well-being in outpatients with diabetes: effects on mood, HbA(1c), and the patient's evaluation of the quality of diabetes care: a randomized controlled trial." Diabetes care 24 (11) doi:
Mollema E D, Snoek F J, Adèr H J, Heine R J, van der Ploeg H M 2001. "Insulin-treated diabetes patients with fear of self-injecting or fear of self-testing: psychological comorbidity and general well-being." Journal of psychosomatic research 51 (5) doi:
Snoek F J, van der Ven N C, Lubach C H, Chatrou M, Adèr H J, et al. 2001. "Effects of cognitive behavioural group training (CBGT) in adult patients with poorly controlled insulin-dependent (type 1) diabetes: a pilot study." Patient education and counseling 45 (2) doi:
Gerritsen J, Dekker J M, TenVoorde B J, Kostense P J, Heine R J, et al. 2001. "Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study." Diabetes care 24 (10) doi:
van Dijk R A, Dekker J M, Nijpels G, Heine R J, Bouter L M, Stehouwer C D 2001. "Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance." European journal of clinical investigation 31 (9) doi:
Mollema E D, Snoek F J, Heine R J, van der Ploeg H M 2001. "Phobia of self-injecting and self-testing in insulin-treated diabetes patients: opportunities for screening." Diabetic medicine : a journal of the British Diabetic Association 18 (8) doi:
Rustemeijer C, Schouten J A, Voerman H J, Beynen A C, Donker A J, Heine R J 2001. "Is pseudocholinesterase activity related to markers of triacylglycerol synthesis in Type II diabetes mellitus?" Clinical science (London, England : 1979) 101 (1) doi:
van der Wal P S, Heine R J 2001. "Characteristics of pancreatic beta-cell secretion in Type 2 diabetic patients treated with gliclazide and glibenclamide." Diabetes research and clinical practice 52 (2) doi:
de Vegt F, Dekker J M, Jager A, Hienkens E, Kostense P J, et al. 2001. "Relation of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch population: The Hoorn Study." JAMA : the journal of the American Medical Association 285 (16) doi:
Bakker S J, Gans R O, ter Maaten J C, Teerlink T, Westerhoff H V, Heine R J 2001. "The potential role of adenosine in the pathophysiology of the insulin resistance syndrome." Atherosclerosis 155 (2) doi:
Bakker S J, ter Maaten J C, Popp-Snijders C, Slaets J P, Heine R J, Gans R O 2001. "The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects." The Journal of clinical endocrinology and metabolism 86 (3) doi:
Jager A, van Hinsbergh V W, Kostense P J, Emeis J J, Nijpels G, et al. 2001. "Prognostic implications of retinopathy and a high plasma von Willebrand factor concentration in type 2 diabetic subjects with microalbuminuria." Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 16 (3) doi:
Scheffer P G, Bakker S J, Popp-Snijders C, Heine R J, Schutgens R B, Teerlink T 2001. "Composition of LDL as determinant of its susceptibility to in vitro oxidation in patients with well-controlled type 2 diabetes." Diabetes/metabolism research and reviews 17 (6) doi:
Jager A, Kostense P J, Nijpels G, Dekker J M, Heine R J, et al. 2001. "Serum homocysteine levels are associated with the development of (micro)albuminuria: the Hoorn study." Arteriosclerosis, thrombosis, and vascular biology 21 (1) doi:

2000

Hoogeveen E K, Kostense P J, Eysink P E, Polak B C, Beks P J, et al. 2000. "Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn study." Archives of internal medicine 160 (19) doi:
Smulders Y M, Jager A, Gerritsen J, Dekker J M, Nijpels G, et al. 2000. "Cardiovascular autonomic function is associated with (micro-)albuminuria in elderly Caucasian sujects with impaired glucose tolerance or type 2 diabetes: the Hoorn Study." Diabetes care 23 (9) doi:
Becker A, Van Hinsbergh V W, Kostense P J, Jager A, Dekker J M, et al. 2000. "Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C-reactive protein in type 2 diabetic and non-diabetic subjects - The Hoorn Study." European journal of clinical investigation 30 (9) doi:
Mollema E D, Snoek F J, Pouwer F, Heine R J, van der Ploeg H M 2000. "Diabetes Fear of Injecting and Self-Testing Questionnaire: a psychometric evaluation." Diabetes care 23 (6) doi:
Janssen M M, Snoek F J, Masurel N, Hoogma R P, Devillé W L, et al. 2000. "Optimized basal-bolus therapy using a fixed mixture of 75% lispro and 25% NPL insulin in type 1 diabetes patients: no favorable effects on glycemic control, physiological responses to hypoglycemia, well-being, or treatment satisfaction." Diabetes care 23 (5) doi:
Gerritsen J, Dekker J M, TenVoorde B J, Bertelsmann F W, Kostense P J, et al. 2000. "Glucose tolerance and other determinants of cardiovascular autonomic function: the Hoorn Study." Diabetologia 43 (5) doi:10.1007/s001250051344
Hoogeveen E K, Kostense P J, Jakobs C, Dekker J M, Nijpels G, et al. 2000. "Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study." Circulation 101 (13) doi:
Janssen M M, Snoek F J, Heine R J 2000. "Assessing impaired hypoglycemia awareness in type 1 diabetes: agreement of self-report but not of field study data with the autonomic symptom threshold during experimental hypoglycemia." Diabetes care 23 (4) doi:
Hart L M, Dekker J M, van Haeften T W, Ruige J B, Stehouwer C D, et al. 2000. "Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus." Diabetologia 43 (4) doi:
Hoogeveen E K, Kostense P J, Jakobs C, Rauwerda J A, Dekker J M, et al. 2000. "Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: The Hoorn Study." Journal of internal medicine 247 (4) doi:
van Dijk R A, Nijpels G, Twisk J W, Steyn M, Dekker J M, et al. 2000. "Change in common carotid artery diameter, distensibility and compliance in subjects with a recent history of impaired glucose tolerance: a 3-year follow-up study." Journal of hypertension 18 (3) doi:
Pouwer F, Snoek F J, van der Ploeg H M, Adèr H J, Heine R J 2000. "The well-being questionnaire: evidence for a three-factor structure with 12 items (W-BQ12)." Psychological medicine 30 (2) doi:
Jager A, van Hinsbergh V W, Kostense P J, Emeis J J, Nijpels G, et al. 2000. "Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study." Diabetes 49 (3) doi:
Mooy J M, de Vries H, Grootenhuis P A, Bouter L M, Heine R J 2000. "Major stressful life events in relation to prevalence of undetected type 2 diabetes: the Hoorn Study." Diabetes care 23 (2) doi:
Franse L V, Valk G D, Dekker J H, Heine R J, van Eijk J T 2000. "'Numbness of the feet' is a poor indicator for polyneuropathy in Type 2 diabetic patients." Diabetic medicine : a journal of the British Diabetic Association 17 (2) doi:
Bakker S J, IJzerman R G, Teerlink T, Westerhoff H V, Gans R O, Heine R J 2000. "Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure?" Atherosclerosis 148 (1) doi:
Janssen M M, Snoek F J, de Jongh R T, Casteleijn S, Devillé W, Heine R J 2000. "Biological and behavioural determinants of the frequency of mild, biochemical hypoglycaemia in patients with Type 1 diabetes on multiple insulin injection therapy." Diabetes/metabolism research and reviews 16 (3) doi:
de Vegt F, Dekker J M, Stehouwer C D, Nijpels G, Bouter L M, Heine R J 2000. "Similar 9-year mortality risks and reproducibility for the World Health Organization and American Diabetes Association glucose tolerance categories: the Hoorn Study." Diabetes care 23 (1) doi:
Rustemeijer C, Schouten J A, Voerman H J, Hensgens H E, Donker A J, Heine R J 2000. "Pravastatin compared to bezafibrate in the treatment of dyslipidemia in insulin-treated patients with type 2 diabetes mellitus." Diabetes/metabolism research and reviews 16 (2) doi:

1999

Heine R J 1999. "Diabetes in the next century: challenges and opportunities." The Netherlands journal of medicine 55 (6) doi:
Hoogeveen E K, Kostense P J, Valk G D, Bertelsmann F W, Jakobs C, et al. 1999. "Hyperhomocysteinaemia is not related to risk of distal somatic polyneuropathy: the Hoorn Study." Journal of internal medicine 246 (6) doi:
Jager A, van Hinsbergh V W, Kostense P J, Emeis J J, Yudkin J S, et al. 1999. "von Willebrand factor, C-reactive protein, and 5-year mortality in diabetic and nondiabetic subjects: the Hoorn Study." Arteriosclerosis, thrombosis, and vascular biology 19 (12) doi:
Pouwer F, van der Ploeg H M, Adèr H J, Heine R J, Snoek F J 1999. "The 12-item well-being questionnaire. An evaluation of its validity and reliability in Dutch people with diabetes." Diabetes care 22 (12) doi:
Bakker S J, ter Maaten J C, Popp-Snijders C, Heine R J, Gans R O 1999. "Triiodothyronine: a link between the insulin resistance syndrome and blood pressure?" Journal of hypertension 17 (12 Pt 1) doi:
Wiersma T J, Heine R J, Rutten G E 1999. "[Summary of the practice guideline 'Diabetes mellitus type 2' (first revision) of the Dutch College of General Practitioners]." Nederlands tijdschrift voor geneeskunde 143 (33) doi:
de Vegt F, Dekker J M, Ruhé H G, Stehouwer C D, Nijpels G, et al. 1999. "Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study." Diabetologia 42 (8) doi:10.1007/s001250051249
Bouma M, Dekker J H, van Eijk J T, Schellevis F G, Kriegsman D M, Heine R J 1999. "Metabolic control and morbidity of type 2 diabetic patients in a general practice network." Family practice 16 (4) doi:
Ruige J B, Dekker J M, Blum W F, Stehouwer C D, Nijpels G, et al. 1999. "Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study." Diabetes care 22 (7) doi:
Wolffenbuttel B H, Heine R J 1999. "[Glycemic regulation and management of essential hypertension in diabetics with type 2 diabetes mellitus; the 'United Kingdom prospective diabetes study' of diabetic complications]." Nederlands tijdschrift voor geneeskunde 143 (23) doi:
Heine R J 1999. "Current therapeutic options in type 2 diabetes." European journal of clinical investigation 29 Suppl 2 doi:
Bouma M, Dekker J H, de Sonnaville J J, van der Does F E, de Vries H, et al. 1999. "How valid is fasting plasma glucose as a parameter of glycemic control in non-insulin-using patients with type 2 diabetes?" Diabetes care 22 (6) doi:
Hart L M, de Knijff P, Dekker J M, Stolk R P, Nijpels G, et al. 1999. "Variants in the sulphonylurea receptor gene: association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians." Diabetologia 42 (5) doi:
t Hart L M, Ruige J B, Dekker J M, Stehouwer C D, Maassen J A, Heine R J 1999. "Altered beta-cell characteristics in impaired glucose tolerant carriers of a GAA trinucleotide repeat polymorphism in the frataxin gene." Diabetes 48 (4) doi:
Hart L M, Stolk R P, Dekker J M, Nijpels G, Grobbee D E, et al. 1999. "Prevalence of variants in candidate genes for type 2 diabetes mellitus in The Netherlands: the Rotterdam study and the Hoorn study." The Journal of clinical endocrinology and metabolism 84 (3) doi:
Jager A, Kostense P J, Ruhé H G, Heine R J, Nijpels G, et al. 1999. "Microalbuminuria and peripheral arterial disease are independent predictors of cardiovascular and all-cause mortality, especially among hypertensive subjects: five-year follow-up of the Hoorn Study." Arteriosclerosis, thrombosis, and vascular biology 19 (3) doi:
Ruige J B, Dekker J M, Nijpels G, Popp-Snijders C, Stehouwer C D, et al. 1999. "Hyperproinsulinaemia in impaired glucose tolerance is associated with a delayed insulin response to glucose." Diabetologia 42 (2) doi:10.1007/s001250051136
Baan C A, Ruige J B, Stolk R P, Witteman J C, Dekker J M, et al. 1999. "Performance of a predictive model to identify undiagnosed diabetes in a health care setting." Diabetes care 22 (2) doi:

1998

van der Does F E, de Neeling J N, Snoek F J, Grootenhuis P A, Kostense P J, et al. 1998. "Randomized study of two different target levels of glycemic control within the acceptable range in type 2 diabetes. Effects on well-being at 1 year." Diabetes care 21 (12) doi:
Bakker S J, Hoogeveen E K, Nijpels G, Kostense P J, Dekker J M, et al. 1998. "The association of dietary fibres with glucose tolerance is partly explained by concomitant intake of thiamine: the Hoorn Study." Diabetologia 41 (10) doi:10.1007/s001250051047
de Vegt F, Dekker J M, Stehouwer C D, Nijpels G, Bouter L M, Heine R J 1998. "The 1997 American Diabetes Association criteria versus the 1985 World Health Organization criteria for the diagnosis of abnormal glucose tolerance: poor agreement in the Hoorn Study." Diabetes care 21 (10) doi:
Scheffer P G, Bakker S J, Heine R J, Teerlink T 1998. "Measurement of LDL particle size in whole plasma and serum by high performance gel-filtration chromatography using a fluorescent lipid probe." Clinical chemistry 44 (10) doi:
Seissler J, de Sonnaville J J, Morgenthaler N G, Steinbrenner H, Glawe D, et al. 1998. "Immunological heterogeneity in type I diabetes: presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease." Diabetologia 41 (8) doi:10.1007/s001250051004
Hoogeveen E K, Kostense P J, Jager A, Heine R J, Jakobs C, et al. 1998. "Serum homocysteine level and protein intake are related to risk of microalbuminuria: the Hoorn Study." Kidney international 54 (1) doi:10.1038/sj.ki.4495353
Jager A, Kostense P J, Nijpels G, Heine R J, Bouter L M, Stehouwer C D 1998. "Microalbuminuria is strongly associated with NIDDM and hypertension, but not with the insulin resistance syndrome: the Hoorn Study." Diabetologia 41 (6) doi:10.1007/s001250050970
de Sonnaville J J, Snoek F J, Colly L P, Devillé W, Wijkel D, Heine R J 1998. "Well-being and symptoms in relation to insulin therapy in type 2 diabetes." Diabetes care 21 (6) doi:
Grootenhuis P A, Mooy J M, Kostense P J, Popp-Snijders C, Bouter L M, Heine R J 1998. "Dissimilar association of conventional immuno-reactive versus specific insulin with cardiovascular risk factors: a consequence of proinsulinaemia?" Diabetes research and clinical practice 40 (2) doi:
Friedberg C E, Janssen M J, Heine R J, Grobbee D E 1998. "Fish oil and glycemic control in diabetes. A meta-analysis." Diabetes care 21 (4) doi:
Ruige J B, Assendelft W J, Dekker J M, Kostense P J, Heine R J, Bouter L M 1998. "Insulin and risk of cardiovascular disease: a meta-analysis." Circulation 97 (10) doi:
Kanc K, Janssen M M, Keulen E T, Jacobs M A, Popp-Snijders C, et al. 1998. "Substitution of night-time continuous subcutaneous insulin infusion therapy for bedtime NPH insulin in a multiple injection regimen improves counterregulatory hormonal responses and warning symptoms of hypoglycaemia in IDDM." Diabetologia 41 (3) doi:10.1007/s001250050910
Wolffenbuttel B H, Heine R J 1998. "[Short-acting insulin analogs]." Nederlands tijdschrift voor geneeskunde 142 (8) doi:
Stolk R P, de Vegt F, Heine R J 1998. "[What are the consequences of the new American guidelines for the diagnosis of diabetes mellitus in The Netherlands?]." Nederlands tijdschrift voor geneeskunde 142 (5) doi:
Pouwer F, Snoek F J, van der Ploeg H M, Heine R J, Brand A N 1998. "A comparison of the standard and the computerized versions of the Well-being Questionnaire (WBQ) and the Diabetes Treatment Satisfaction Questionnaire (DTSQ)." Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 7 (1) doi:
Hoogeveen E K, Kostense P J, Beks P J, Mackaay A J, Jakobs C, et al. 1998. "Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study." Arteriosclerosis, thrombosis, and vascular biology 18 (1) doi:
Mooy J M, Grootenhuis P A, de Vries H, Bouter L M, Kostense P J, Heine R J 1998. "Determinants of specific serum insulin concentrations in a general Caucasian population aged 50 to 74 years (the Hoorn Study)." Diabetic medicine : a journal of the British Diabetic Association 15 (1) doi:10.1002/(SICI)1096-9136(199801)15:1<45::AID-DIA503>3.0.CO;2-M

1997

Janssen M M, Casteleijn S, Devillé W, Popp-Snijders C, Roach P, Heine R J 1997. "Nighttime insulin kinetics and glycemic control in type 1 diabetes patients following administration of an intermediate-acting lispro preparation." Diabetes care 20 (12) doi:
Hoogeveen E K, Kostense P J, Jakobs C, Bouter L M, Heine R J, Stehouwer C D 1997. "Does metformin increase the serum total homocysteine level in non-insulin-dependent diabetes mellitus?" Journal of internal medicine 242 (5) doi:
de Sonnaville J J, Bouma M, Colly L P, Devillé W, Wijkel D, Heine R J 1997. "Sustained good glycaemic control in NIDDM patients by implementation of structured care in general practice: 2-year follow-up study." Diabetologia 40 (11) doi:10.1007/s001250050829
Scheffer P G, Bakker S J, Heine R J, Teerlink T 1997. "Measurement of low-density lipoprotein particle size by high-performance gel-filtration chromatography." Clinical chemistry 43 (10) doi:
Snoek F J, Mollema E D, Heine R J, Bouter L M, van der Ploeg H M 1997. "Development and validation of the diabetes fear of injecting and self-testing questionnaire (D-FISQ): first findings." Diabetic medicine : a journal of the British Diabetic Association 14 (10) doi:10.1002/(SICI)1096-9136(199710)14:10<871::AID-DIA457>3.0.CO;2-Y
Nijpels G, Popp-Snijders C, Kostense P J, Bouter L M, Heine R J 1997. "Cardiovascular risk factors prior to the development of non-insulin-dependent diabetes mellitus in persons with impaired glucose tolerance: the Hoorn Study." Journal of clinical epidemiology 50 (9) doi:
Jacobs M A, Keulen E T, Kanc K, Casteleijn S, Scheffer P, et al. 1997. "Metabolic efficacy of preprandial administration of Lys(B28), Pro(B29) human insulin analog in IDDM patients. A comparison with human regular insulin during a three-meal test period." Diabetes care 20 (8) doi:
van der Wal P S, Draeger K E, van Iperen A M, Martini C, Aarsen M, Heine R J 1997. "Beta cell response to oral glimepiride administration during and following a hyperglycaemic clamp in NIDDM patients." Diabetic medicine : a journal of the British Diabetic Association 14 (7) doi:10.1002/(SICI)1096-9136(199707)14:7<556::AID-DIA389>3.0.CO;2-6
Ruige J B, Batstra M R, Aanstoot H J, Bouter L M, Bruining G J, et al. 1997. "Low prevalence of antibodies to GAD65 in a 50- to 74-year-old general Dutch population. The Hoorn Study." Diabetes care 20 (7) doi:
Ruige J B, de Neeling J N, Kostense P J, Bouter L M, Heine R J 1997. "Performance of an NIDDM screening questionnaire based on symptoms and risk factors." Diabetes care 20 (4) doi:
de Sonnaville J J, Colly L P, Wijkel D, Heine R J 1997. "The prevalence and determinants of foot ulceration in type II diabetic patients in a primary health care setting." Diabetes research and clinical practice 35 (2-3) doi:
Bax J J, Visser F C, Raymakers P G, Van Lingen A, Cornel J H, et al. 1997. "Cardiac 18F-FDG-SPET studies in patients with non-insulin-dependent diabetes mellitus during hyperinsulinaemic euglycaemic clamping." Nuclear medicine communications 18 (3) doi:
Beks P H, Mackaay A J, de Vries H, de Neeling J N, Bouter L M, Heine R J 1997. "Carotid artery stenosis is related to blood glucose level in an elderly Caucasian population: the Hoorn Study." Diabetologia 40 (3) doi:10.1007/s001250050676
Jacobs M A, Salobir B, Popp-Snijders C, Ader H, Heine R J 1997. "Counterregulatory hormone responses and symptoms during hypoglycaemia induced by porcine, human regular insulin, and Lys(B28), Pro(B29) human insulin analogue (insulin Lispro) in healthy male volunteers." Diabetic medicine : a journal of the British Diabetic Association 14 (3) doi:10.1002/(SICI)1096-9136(199703)14:3<248::AID-DIA337>3.0.CO;2-0
Polak B C, Heine R J 1997. "[Eye symptoms and latent diabetes]." Nederlands tijdschrift voor geneeskunde 141 (2) doi:
Ter Maaten J C, Voorburg A, Heine R J, Ter Wee P M, Donker A J, Gans R O 1997. "Renal handling of urate and sodium during acute physiological hyperinsulinaemia in healthy subjects." Clinical science (London, England : 1979) 92 (1) doi:
Bax J J, Veening M A, Visser F C, van Lingen A, Heine R J, et al. 1997. "Optimal metabolic conditions during fluorine-18 fluorodeoxyglucose imaging; a comparative study using different protocols." European journal of nuclear medicine 24 (1) doi:

1996

Mollem E D, Snoek F J, Heine R J 1996. "Assessment of perceived barriers in self-care of insulin-requiring diabetic patients." Patient education and counseling 29 (3) doi:
Hart L M, Stolk R P, Heine R J, Grobbee D E, van der Does F E, Maassen J A 1996. "Association of the insulin-receptor variant Met-985 with hyperglycemia and non-insulin-dependent diabetes mellitus in the Netherlands: a population-based study." American journal of human genetics 59 (5) doi:
de Neeling J N, Beks P J, Bertelsmann F W, Heine R J, Bouter L M 1996. "Peripheral somatic nerve function in relation to glucose tolerance in an elderly Caucasian population: the Hoorn study." Diabetic medicine : a journal of the British Diabetic Association 13 (11) doi:10.1002/(SICI)1096-9136(199611)13:11<960::AID-DIA268>3.0.CO;2-Z
Ruwaard D, Nijdam K H, Heine R J, Krans H M, van Ooijen J P, Storms G E 1996. "Diabetes monitoring system in The Netherlands." Diabetes research and clinical practice 34 Suppl doi:
Merbis M A, Snoek F J, Kanc K, Heine R J 1996. "Hypoglycaemia induces emotional disruption." Patient education and counseling 29 (1) doi:
Heine R J 1996. "Role of sulfonylureas in non-insulin-dependent diabetes mellitus: Part II--"The cons"." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 28 (9) doi:10.1055/s-2007-979845
de Sonnaville J J, van der Feltz van der Sloot D, Ernst L, Wijkel D, Heine R J 1996. "Retinopathy screening in type 2 diabetes: reliability of wide angle fundus photography." Diabetic medicine : a journal of the British Diabetic Association 13 (5) doi:10.1002/(SICI)1096-9136(199605)13:5<482::AID-DIA95>3.0.CO;2-I
Van der Does F E, De Neeling J N, Snoek F J, Kostense P J, Grootenhuis P A, et al. 1996. "Symptoms and well-being in relation to glycemic control in type II diabetes." Diabetes care 19 (3) doi:
Mooy J M, Grootenhuis P A, de Vries H, Kostense P J, Popp-Snijders C, et al. 1996. "Intra-individual variation of glucose, specific insulin and proinsulin concentrations measured by two oral glucose tolerance tests in a general Caucasian population: the Hoorn Study." Diabetologia 39 (3) doi:
Heine R J, Mooy J M 1996. "Impaired glucose tolerance and unidentified diabetes." Postgraduate medical journal 72 (844) doi:
Heine R J, Nijpels G, Mooy J M 1996. "New data on the rate of progression of impaired glucose tolerance to NIDDM and predicting factors." Diabetic medicine : a journal of the British Diabetic Association 13 (3 Suppl 2) doi:
Nijpels G, Popp-Snijders C, Kostense P J, Bouter L M, Heine R J 1996. "Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study." Diabetologia 39 (1) doi:

1995

Huitink J M, Visser F C, van Leeuwen G R, van Lingen A, Bax J J, et al. 1995. "Influence of high and low plasma insulin levels on the uptake of fluorine-18 fluorodeoxyglucose in myocardium and femoral muscle, assessed by planar imaging." European journal of nuclear medicine 22 (10) doi:
Mooy J M, Grootenhuis P A, de Vries H, Valkenburg H A, Bouter L M, et al. 1995. "Prevalence and determinants of glucose intolerance in a Dutch caucasian population. The Hoorn Study." Diabetes care 18 (9) doi:
Mackaay A J, Beks P J, Dur A H, Bischoff M, Scholma J, et al. 1995. "The distribution of peripheral vascular disease in a Dutch Caucasian population: comparison of type II diabetic and non-diabetic subjects." European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 9 (2) doi:
Beks P J, Mackaay A J, de Neeling J N, de Vries H, Bouter L M, Heine R J 1995. "Peripheral arterial disease in relation to glycaemic level in an elderly Caucasian population: the Hoorn study." Diabetologia 38 (1) doi:

1994

Nijpels G, van der Wal P S, Bouter L M, Heine R J 1994. "Comparison of three methods for the quantification of beta-cell function and insulin sensitivity." Diabetes research and clinical practice 26 (3) doi:
Polderman K H, Gooren L J, Asscheman H, Bakker A, Heine R J 1994. "Induction of insulin resistance by androgens and estrogens." The Journal of clinical endocrinology and metabolism 79 (1) doi:
Ruwaard D, Hirasing R A, Reeser H M, van Buuren S, Bakker K, et al. 1994. "Increasing incidence of type I diabetes in The Netherlands. The second nationwide study among children under 20 years of age." Diabetes care 17 (6) doi:
Blonk M C, Jacobs M A, Biesheuvel E H, Weeda-Mannak W L, Heine R J 1994. "Influences on weight loss in type 2 diabetic patients: little long-term benefit from group behaviour therapy and exercise training." Diabetic medicine : a journal of the British Diabetic Association 11 (5) doi:
Grootenhuis P A, Snoek F J, Heine R J, Bouter L M 1994. "Development of a type 2 diabetes symptom checklist: a measure of symptom severity." Diabetic medicine : a journal of the British Diabetic Association 11 (3) doi:
Blonk M C, Jacobs M A, Friedberg C E, Nauta J J, Teerlink T, et al. 1994. "Determinants of insulin sensitivity and consequences for lipoproteins and blood pressure in subjects with non-insulin-dependent diabetes mellitus." Metabolism: clinical and experimental 43 (4) doi:
de Neeling J N, Beks P J, Bertelsmann F W, Heine R J, Bouter L M 1994. "Sensory thresholds in older adults: reproducibility and reference values." Muscle & nerve 17 (4) doi:10.1002/mus.880170414

1993

Jacobs M A, Schreuder R H, Jap-A-Joe K, Nauta J J, Andersen P M, Heine R J 1993. "The pharmacodynamics and activity of intranasally administered insulin in healthy male volunteers." Diabetes 42 (11) doi:

1992

Wahab P J, Rijnsburger A W, Oolbekkink M, Heine R J 1992. "Venous versus arterialised venous blood for assessment of blood glucose levels during glucose clamping: comparison in healthy men." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 24 (12) doi:10.1055/s-2007-1003393
Gans R O, Bilo H J, Nauta J J, Heine R J, Donker A J 1992. "Acute hyperinsulinemia induces sodium retention and a blood pressure decline in diabetes mellitus." Hypertension 20 (2) doi:

1991

Gans R O, Bilo H J, Nauta J J, Popp-Snijders C, Heine R J, Donker A J 1991. "The effect of angiotensin-I converting enzyme inhibition on insulin action in healthy volunteers." European journal of clinical investigation 21 (5) doi:
Gans R O, Bilo H J, von Maarschalkerweerd W W, Heine R J, Nauta J J, Donker A J 1991. "Exogenous insulin augments in healthy volunteers the cardiovascular reactivity to noradrenaline but not to angiotensin II." The Journal of clinical investigation 88 (2) doi:10.1172/JCI115333
Gans R O, vd Toorn L, Bilo H J, Nauta J J, Heine R J, Donker A J 1991. "Renal and cardiovascular effects of exogenous insulin in healthy volunteers." Clinical science (London, England : 1979) 80 (3) doi:
Heine R J 1991. "Non-insulin dependent diabetes mellitus: a phenomenon of ageing?" International journal of epidemiology 20 Suppl 1 doi:

1989

Heine R J, van der Heyden E A, van der Veen E A 1989. "Responses to human and porcine insulin in healthy subjects." Lancet 2 (8669) doi:
Houtzagers C M, Visser A P, Berntzen P A, van der Stap H, van Maarschalkerweerd W W, et al. 1989. "Multiple daily insulin injections improve self-confidence." Diabetic medicine : a journal of the British Diabetic Association 6 (6) doi:
Houtzagers C M, Berntzen P A, van der Stap H, van Maarschalkerweerd W W, Lanting P, et al. 1989. "Efficacy and acceptance of two intensified conventional insulin therapy regimens: a long-term cross-over comparison." Diabetic medicine : a journal of the British Diabetic Association 6 (5) doi:
Heine R J, Mulder C, Popp-Snijders C, van der Meer J, van der Veen E A 1989. "Linoleic-acid-enriched diet: long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin-dependent diabetic patients." The American journal of clinical nutrition 49 (3) doi:
Oolbekkink M, Heine R J, den Hollander W, Nauta J J, van der Veen E A 1989. "Hepatic 123I-insulin binding kinetics in non-insulin-dependent (type 2) diabetic patients after i.v. bolus administration." European journal of nuclear medicine 15 (6) doi:

1988

Heine R J 1988. "Insulin treatment of non-insulin-dependent diabetes mellitus." Baillière's clinical endocrinology and metabolism 2 (2) doi:
Houtzagers C M, Visser A P, Berntzen P A, Heine R J, van der Veen E A 1988. "The Medi-Jector II: efficacy and acceptability in insulin-dependent diabetic patients with and without needle phobia." Diabetic medicine : a journal of the British Diabetic Association 5 (2) doi:

1987

Gans R O, Heine R J, Donker A J, van der Veen E A 1987. "Influence of salt on glycaemic response to carbohydrate loading." British medical journal (Clinical research ed.) 294 (6582) doi:
Popp-Snijders C, Schouten J A, Heine R J, van der Meer J, van der Veen E A 1987. "Dietary supplementation of omega-3 polyunsaturated fatty acids improves insulin sensitivity in non-insulin-dependent diabetes." Diabetes research (Edinburgh, Scotland) 4 (3) doi:
Bilo H J, Heine R J, Sikkenk A C, van der Meer J, van der Veen E A 1987. "Absorption kinetics and action profiles after sequential subcutaneous administration of human soluble and lente insulin through one needle." Diabetes care 10 (4) doi:
Wahab P J, Rijnsburger A W, van der Veen E A, Heine R J 1987. "The absorption kinetics of subcutaneously infused U 40 and U 100 insulin in diabetics." Diabetes research and clinical practice 3 (4) doi:
Bilo H J, Heine R J, Sikkenk A C, van der Meer J, van der Veen E A 1987. "Absorption kinetics and action profiles of intermediate acting human insulins." Diabetes research (Edinburgh, Scotland) 4 (1) doi:
Heine R J, Van der Stap H, Salemink P J, Kolkman-Roodbeen J C, Banken P, et al. 1987. "Pharmacokinetics and miscibility of 4 highly purified porcine insulins: a study in vitro and in healthy volunteers." Diabetes research (Edinburgh, Scotland) 4 (1) doi:

1986

Heine R J, Bilo H J, van der Meer J, van der Veen E A 1986. "Sequential infusions of glucose and insulin at prefixed rates: a simple method for assessing insulin sensitivity and insulin responsiveness." Diabetes research (Edinburgh, Scotland) 3 (9) doi:
Bertelsmann F W, Heimans J J, van Rooy J C, Heine R J, van der Veen E A 1986. "Reproducibility of vibratory perception thresholds in patients with diabetic neuropathy." Diabetes research (Edinburgh, Scotland) 3 (9) doi:
Heine R J, Sikkenk A C, Eizenga W H, van der Veen E A 1986. "Delayed onset of action of soluble insulin after premixing with U100 lente insulin." Diabetes research and clinical practice 2 (6) doi:

1985

Heine R J, Home P D, Poncher M, Orskov H, Hammond V, et al. 1985. "A comparison of 3 methods for assessing insulin sensitivity in subjects with normal and abnormal glucose tolerance." Diabetes research (Edinburgh, Scotland) 2 (3) doi:
Heine R J, Sikkenk A C, Bilo H J, van der Meer J, van der Veen E A 1985. "Comparison of two commonly used insulin injection techniques." Diabetic medicine : a journal of the British Diabetic Association 2 (3) doi:
Taylor R, Heine R J, Collins J, James O F, Alberti K G 1985. "Insulin action in cirrhosis." Hepatology (Baltimore, Md.) 5 (1) doi:

1984

Heine R J, Bilo H J, Fonk T, van der Veen E A, van der Meer J 1984. "Absorption kinetics and action profiles of mixtures of short- and intermediate-acting insulins." Diabetologia 27 (6) doi:
Heine R J, Ponchner M, Hanning I, Home P D, Brown M, et al. 1984. "A comparison of the effects of semisynthetic human insulin and porcine insulin on transmembrane ion shifts and glucose metabolism during euglycaemic clamping." Acta endocrinologica 106 (2) doi:
Ponchner M, Heine R J, Pernet A, Hanning I, Francis A J, et al. 1984. "A comparison of the artificial pancreas (glucose controlled insulin infusion system) and a manual technique for assessing insulin sensitivity during euglycaemic clamping." Diabetologia 26 (6) doi:
Heine R J, Schouten J A, van Gent C M, Havekes L M, Koopman P A, van der Veen E A 1984. "The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys." Annals of nutrition & metabolism 28 (4) doi:

1983

Heine R J, Hanning I, Morgan L, Alberti K G 1983. "The oral glucose tolerance test (OGTT): effect of rate of ingestion of carbohydrate and different carbohydrate preparations." Diabetes care 6 (5) doi: