Pulmonary actinomycosis complicating infliximab therapy for Crohn's disease.

Thorax, 2007; 62 (11) doi:10.1136/thx.2006.075150

Authors: Cohen R D, Bowie W R, Enns R, Flint J, Fitzgerald J M

Affiliation: University of British Columbia, Canada

Abstract: The use of anti-tumour necrosis factor (TNF) agents has expanded significantly over the past few years, particularly for rheumatological diseases and Crohn's disease. A number of associated opportunistic infections have been observed as a result of suppression of T cell-mediated immunity, the most frequent being tuberculosis. We report the first case of pulmonary actinomycosis in a patient receiving regular infusions of infliximab, an anti-TNF agent, for Crohn's disease.

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